Development of isatin-thiazolo[3,2-a]benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and molecular dynamics investigations.
Eldehna WM, El Hassab MA, Abo-Ashour MF, Al-Warhi T, Elaasser MM, Safwat NA, Suliman H, Ahmed MF, Al-Rashood ST, Abdel-Aziz HA, El-Haggar R.
Eldehna WM, et al. Among authors: el haggar r.
Bioorg Chem. 2021 May;110:104748. doi: 10.1016/j.bioorg.2021.104748. Epub 2021 Feb 18.
Bioorg Chem. 2021.
PMID: 33684714
This could be attributed to an incorporation of the 5-OCH(3) group that was engaged in an extra hydrogen bonding with key THR14 amino acid residue. Finally, these results suggested hybrid 7d as a good candidate for further optimization as promising breast cancer antitumor …
This could be attributed to an incorporation of the 5-OCH(3) group that was engaged in an extra hydrogen bonding with key THR14 amino …