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1981 1
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289 results

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Page 1
Malaria.
White NJ, Pukrittayakamee S, Hien TT, Faiz MA, Mokuolu OA, Dondorp AM. White NJ, et al. Lancet. 2014 Feb 22;383(9918):723-35. doi: 10.1016/S0140-6736(13)60024-0. Epub 2013 Aug 15. Lancet. 2014. PMID: 23953767 Review.
Chemopreventive strategies have been increasingly deployed in Africa, notably intermittent sulfadoxine-pyrimethamine treatment in pregnancy, and monthly amodiaquine-sulfadoxine-pyrimethamine during the rainy season months in children aged between 3 months and 5 years acros …
Chemopreventive strategies have been increasingly deployed in Africa, notably intermittent sulfadoxine-pyrimethamine treatment in pregnancy, …
Potential Antiviral Options against SARS-CoV-2 Infection.
Ianevski A, Yao R, Fenstad MH, Biza S, Zusinaite E, Reisberg T, Lysvand H, Løseth K, Landsem VM, Malmring JF, Oksenych V, Erlandsen SE, Aas PA, Hagen L, Pettersen CH, Tenson T, Afset JE, Nordbø SA, Bjørås M, Kainov DE. Ianevski A, et al. Viruses. 2020 Jun 13;12(6):642. doi: 10.3390/v12060642. Viruses. 2020. PMID: 32545799 Free PMC article.
However, developing novel virus-specific vaccines, monoclonal antibodies and antiviral drugs against SARS-CoV-2 can be time-consuming and costly. Convalescent sera and safe-in-man broad-spectrum antivirals (BSAAs) are readily available treatment options. ...We also …
However, developing novel virus-specific vaccines, monoclonal antibodies and antiviral drugs against SARS-CoV-2 can be time-consuming …
Strong anti-viral nano biocide based on Ag/ZnO modified by amodiaquine as an antibacterial and antiviral composite.
Dolatyari M, Rostami A. Dolatyari M, et al. Sci Rep. 2022 Nov 19;12(1):19934. doi: 10.1038/s41598-022-24540-8. Sci Rep. 2022. PMID: 36402913 Free PMC article.
In this paper, we synthesized Ag/ZnO composite colloidal nanoparticles and the surface of nanoparticles was improved by amodiaquine ligand. The synthesized nanoparticles were characterized using the XRD diffraction pattern, FT-IR Spectroscopy, TEM image, and UV-Vis spectro …
In this paper, we synthesized Ag/ZnO composite colloidal nanoparticles and the surface of nanoparticles was improved by amodiaquine l …
Novel amodiaquine derivatives potently inhibit Ebola virus infection.
Sakurai Y, Sakakibara N, Toyama M, Baba M, Davey RA. Sakurai Y, et al. Antiviral Res. 2018 Dec;160:175-182. doi: 10.1016/j.antiviral.2018.10.025. Epub 2018 Nov 3. Antiviral Res. 2018. PMID: 30395872 Free PMC article.
When these modifications were combined, the antiviral efficacy could be further improved with the selectivity indexes being over 10-times higher than amodiaquine. Mechanistic evaluation demonstrated that the potent derivatives blocked host cell entry of Ebola virus, …
When these modifications were combined, the antiviral efficacy could be further improved with the selectivity indexes being over 10-t …
Amodiaquine derivatives as inhibitors of severe fever with thrombocytopenia syndrome virus (SFTSV) replication.
Baba M, Okamoto M, Toyama M, Sakakibara N, Shimojima M, Saijo M, Niwa T, Yagi Y. Baba M, et al. Antiviral Res. 2023 Feb;210:105479. doi: 10.1016/j.antiviral.2022.105479. Epub 2022 Dec 22. Antiviral Res. 2023. PMID: 36566117 Free article.
We have previously isolated SFTSV from blood samples of SFTS patients and established an antiviral assay system to identify selective inhibitors of SFTSV in vitro. Using the assay system, the antimalarial agent amodiaquine was identified as a selective inhibitor of …
We have previously isolated SFTSV from blood samples of SFTS patients and established an antiviral assay system to identify selective …
The antimalarial drug amodiaquine possesses anti-ZIKA virus activities.
Han Y, Mesplède T, Xu H, Quan Y, Wainberg MA. Han Y, et al. J Med Virol. 2018 May;90(5):796-802. doi: 10.1002/jmv.25031. Epub 2018 Feb 21. J Med Virol. 2018. PMID: 29315671
Here, we explored this strategy and screened eight FDA-approved drugs for antiviral activity against ZIKV using a cell-based assay. Our results show that the antimalarial drug amodiaquine has anti-ZIKV activity with EC(50) at low micromolar concentrations in cell cu …
Here, we explored this strategy and screened eight FDA-approved drugs for antiviral activity against ZIKV using a cell-based assay. O …
In Vivo Activity of Amodiaquine against Ebola Virus Infection.
DeWald LE, Johnson JC, Gerhardt DM, Torzewski LM, Postnikova E, Honko AN, Janosko K, Huzella L, Dowling WE, Eakin AE, Osborn BL, Gahagen J, Tang L, Green CE, Mirsalis JC, Holbrook MR, Jahrling PB, Dyall J, Hensley LE. DeWald LE, et al. Sci Rep. 2019 Dec 27;9(1):20199. doi: 10.1038/s41598-019-56481-0. Sci Rep. 2019. PMID: 31882748 Free PMC article.
We investigated the potential anti-EBOV effect of amodiaquine in a well-characterized nonhuman primate model of EVD. Using a similar 3-day antimalarial dosing strategy as for human patients, plasma concentrations of amodiaquine in healthy animals were similar to tho …
We investigated the potential anti-EBOV effect of amodiaquine in a well-characterized nonhuman primate model of EVD. Using a similar …
Antiviral Drugs Against Severe Fever With Thrombocytopenia Syndrome Virus Infection.
Takayama-Ito M, Saijo M. Takayama-Ito M, et al. Front Microbiol. 2020 Feb 11;11:150. doi: 10.3389/fmicb.2020.00150. eCollection 2020. Front Microbiol. 2020. PMID: 32117168 Free PMC article. Review.
Because the case fatality rate of SFTS is high (6-30%), development of specific and effective treatment for SFTS is required. Studies of potential antiviral drugs for SFTS-specific therapy have been conducted on existing or newly discovered agents in vitro and in vi …
Because the case fatality rate of SFTS is high (6-30%), development of specific and effective treatment for SFTS is required. Studies of pot …
Drug Interactions between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine.
Walimbwa SI, Lamorde M, Waitt C, Kaboggoza J, Else L, Byakika-Kibwika P, Amara A, Gini J, Winterberg M, Chiong J, Tarning J, Khoo SH. Walimbwa SI, et al. Antimicrob Agents Chemother. 2019 Jan 29;63(2):e01310-18. doi: 10.1128/AAC.01310-18. Print 2019 Feb. Antimicrob Agents Chemother. 2019. PMID: 30420479 Free PMC article.
We undertook two pharmacokinetic studies in healthy volunteers, using standard adult doses of artemether-lumefantrine or artesunate-amodiaquine given with 50 mg once daily dolutegravir (DTG) to investigate the drug-drug interaction between artemether-lumefantrine or artesu …
We undertook two pharmacokinetic studies in healthy volunteers, using standard adult doses of artemether-lumefantrine or artesunate-amodi …
Efficacies of artemether-lumefantrine, artesunate-amodiaquine, dihydroartemisinin-piperaquine, and artesunate-pyronaridine for the treatment of uncomplicated Plasmodium falciparum malaria in children aged 6 months to 10 years in Uganda: a randomised, open-label, phase 4 clinical trial.
Kamya MR, Nankabirwa JI, Ebong C, Asua V, Kiggundu M, Orena S, Okitwi M, Tukwasibwe S, Agaba B, Kyabayinze D, Opigo J, Rutazana D, Binagwa B, Mugwanya E, Babirye S, Sebikaari G, Condo PM, Appiah G, Nsobya SL, Conrad MD, Rosenthal PJ, Moriarty LF, Yeka A. Kamya MR, et al. Lancet Infect Dis. 2026 Jan;26(1):67-78. doi: 10.1016/S1473-3099(25)00407-4. Epub 2025 Aug 19. Lancet Infect Dis. 2026. PMID: 40845863 Free PMC article. Clinical Trial.
Our trial aimed to measure the efficacies of artemether-lumefantrine, artesunate-amodiaquine, dihydroartemisinin-piperaquine, and artesunate-pyronaridine in three sites in Uganda. ...Children aged 6 months to 10 years with uncomplicated Plasmodium falciparum malaria were r …
Our trial aimed to measure the efficacies of artemether-lumefantrine, artesunate-amodiaquine, dihydroartemisinin-piperaquine, and art …
289 results