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Year Number of Results
2012 2
2013 2
2014 1
2015 3
2016 4
2017 5
2018 5
2019 8
2020 1
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Molecular signatures in breast cancer
Lal S, et al. Methods 2017 - Review. Among authors: McCart Reed AE. PMID 28669865
Here, we review the approaches that have been used to develop gene expression signatures into currently available diagnostic assays (e.g., OncotypeDX® and Mammaprint®), plus we describe the latest work on genome sequencing, the methodologies used in the discovery process of mutational signatures, and the potential of these signatures to impact the clinic....
Here, we review the approaches that have been used to develop gene expression signatures into currently available diagnostic assays (e
Recent advances in breast cancer research impacting clinical diagnostic practice
McCart Reed AE, et al. J Pathol 2019 - Review. PMID 30426489
We present a detailed discussion of this progress, including advances in the understanding of breast tumour classification, e.g. mixed ductal-lobular tumours and the spectrum of triple-negative breast cancer. ...
We present a detailed discussion of this progress, including advances in the understanding of breast tumour classification, e.g. mixe …
Mixed ductal-lobular carcinomas: evidence for progression from ductal to lobular morphology
McCart Reed AE, et al. J Pathol 2018. PMID 29344954 Free PMC article.
We performed comprehensive clinicopathological analysis of a cohort of 82 MDLs, and found that: (1) MDLs more frequently coexist with ductal carcinoma in situ (DCIS) than with lobular carcinoma in situ (LCIS); (2) the E-cadherin-catenin complex was normal in the ductal component in 77.6% of tumours; and (3) in the lobular component, E-cadherin was almost always aberrantly located in the cytoplasm, in contrast to invasive lobular carcinoma (ILC), where E-cadherin is typically absent. ...In MDLs that present with LCIS and DCIS, the clonal divergence probably occurs early, and is frequently associated with complete loss of E-cadherin expression, as in ILC, whereas, in the majority of MDLs, which present with DCIS but not LCIS, direct clonal divergence from the ductal to the lobular phenotype occurs late in tumour evolution, and is associated with aberrant expression of E-cadherin. ...
We performed comprehensive clinicopathological analysis of a cohort of 82 MDLs, and found that: (1) MDLs more frequently coexist with ductal …
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