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3,684 results

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Page 1
Amylin: Pharmacology, Physiology, and Clinical Potential.
Hay DL, Chen S, Lutz TA, Parkes DG, Roth JD. Hay DL, et al. Pharmacol Rev. 2015 Jul;67(3):564-600. doi: 10.1124/pr.115.010629. Pharmacol Rev. 2015. PMID: 26071095 Free article. Review.
Amylin is a pancreatic beta-cell hormone that produces effects in several different organ systems. ...Amylin's major role is as a glucoregulatory hormone, and it is an important regulator of energy metabolism in health and disease. ...
Amylin is a pancreatic beta-cell hormone that produces effects in several different organ systems. ...Amylin's major ro …
Amylin.
Hay DL. Hay DL. Headache. 2017 May;57 Suppl 2:89-96. doi: 10.1111/head.13077. Headache. 2017. PMID: 28485843 Review.
Given the important role of CGRP in migraine and intense efforts to develop drugs against this target, it is important to consider potential areas of overlap between the amylin and CGRP systems. This short review provides a brief introduction to amylin biology, the …
Given the important role of CGRP in migraine and intense efforts to develop drugs against this target, it is important to consider potential …
[Amylin (IAPP) gene].
Sakagashira S, Sanke T. Sakagashira S, et al. Nihon Rinsho. 1997 Oct;55 Suppl:446-51. Nihon Rinsho. 1997. PMID: 9392147 Review. Japanese. No abstract available.
[Amylin/IAPP (islet amyloid polypeptide)--physiology and clinical significance].
Ludvik B. Ludvik B. Wien Klin Wochenschr. 1997 Jun 6;109(11):379-83. Wien Klin Wochenschr. 1997. PMID: 9281227 Review. German.
Amylin or islet amyloid polypeptide (IAPP) is the protein component of amyloid deposits commonly seen in pancreatic islets of patients with type 2 diabetes mellitus. ...The recent availability of an amylin antagonist confirmed the …
Amylin or islet amyloid polypeptide (IAPP) is the protein component of amyloid deposits commonly s …
Development of Cagrilintide, a Long-Acting Amylin Analogue.
Kruse T, Hansen JL, Dahl K, Schäffer L, Sensfuss U, Poulsen C, Schlein M, Hansen AMK, Jeppesen CB, Dornonville de la Cour C, Clausen TR, Johansson E, Fulle S, Skyggebjerg RB, Raun K. Kruse T, et al. J Med Chem. 2021 Aug 12;64(15):11183-11194. doi: 10.1021/acs.jmedchem.1c00565. Epub 2021 Jul 21. J Med Chem. 2021. PMID: 34288673 Free article.
A hallmark of the pancreatic hormone amylin is its high propensity toward the formation of amyloid fibrils, which makes it a challenging drug design effort. The amylin analogue pramlintide is commercially available for diabetes treatment as an adjunct to insu …
A hallmark of the pancreatic hormone amylin is its high propensity toward the formation of amyloid fibrils, which makes it a c …
Amylin brain circuitry.
Boccia L, Gamakharia S, Coester B, Whiting L, Lutz TA, Le Foll C. Boccia L, et al. Peptides. 2020 Oct;132:170366. doi: 10.1016/j.peptides.2020.170366. Epub 2020 Jul 4. Peptides. 2020. PMID: 32634450 Free article. Review.
However, amylin receptor agonist such as salmon calcitonin is able to bind CTR alone. Peripheral amylin's main binding site is located in the area postrema (AP) which then propagate the signal to the nucleus of the solitary tract and lateral parabrachial nucl …
However, amylin receptor agonist such as salmon calcitonin is able to bind CTR alone. Peripheral amylin's main binding …
Metabolic Regulator IAPP (Amylin) Is Required for BRAF and RAS Oncogene-Induced Senescence.
Garnett S, de Bruyns A, Provencher-Tom V, Dutchak K, Shu R, Dankort D. Garnett S, et al. Mol Cancer Res. 2021 May;19(5):874-885. doi: 10.1158/1541-7786.MCR-20-0879. Epub 2021 Jan 26. Mol Cancer Res. 2021. PMID: 33500359 Free article.
Here we show that depletion of a known glycolysis regulator, islet amylin polypeptide (IAPP also known as amylin), prevents RAS and BRAF oncogene-induced senescence (OIS) in human cells. ...Conversely, exogenous treatment of IAPP-depleted …
Here we show that depletion of a known glycolysis regulator, islet amylin polypeptide (IAPP also known as amy …
Creating the amylin story.
Lutz TA. Lutz TA. Appetite. 2022 May 1;172:105965. doi: 10.1016/j.appet.2022.105965. Epub 2022 Feb 17. Appetite. 2022. PMID: 35183619 Free article. Review.
Amylin was discovered as the main constituent of islet amyloid that is predominantly found in pancreatic islets in type 2 diabetics. ...Knowledge of these types of functions and amylin's mechanisms of action lead to the development of amylin …
Amylin was discovered as the main constituent of islet amyloid that is predominantly found in pancreatic islets in type …
Amylin hormone.
Cooper GJ, Willis AC, Leighton B. Cooper GJ, et al. Nature. 1989 Jul 27;340(6231):272. doi: 10.1038/340272b0. Nature. 1989. PMID: 2747794 No abstract available.
Amylin inhibits gastric cancer progression by targeting CCN1 and affecting the PI3K/AKT signalling pathway.
Liu L, Liu W, Deng W. Liu L, et al. Ann Med. 2025 Dec;57(1):2480754. doi: 10.1080/07853890.2025.2480754. Epub 2025 Mar 31. Ann Med. 2025. PMID: 40165038 Free PMC article.
In vitro studies, human GC cell lines were treated with amylin to evaluate the effects of amylin on the proliferation, apoptosis and migration of GC cells. ...Further intervention targeting CCN1 verified its significance as a target of amylin's anti-ca …
In vitro studies, human GC cell lines were treated with amylin to evaluate the effects of amylin on the proliferation, apoptos …
3,684 results