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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
1989 1
1990 1
1992 1
1993 2
1994 7
1995 7
1996 4
1997 4
1998 1
1999 3
2000 5
2001 4
2002 1
2003 4
2004 5
2005 4
2006 6
2007 8
2008 7
2009 9
2010 9
2011 14
2012 12
2013 8
2014 11
2015 11
2016 16
2017 13
2018 15
2019 10
2020 19
2021 12
2022 16
2023 8
2024 10

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240 results

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Page 1
Molecular mechanisms of ferroptosis and their involvement in brain diseases.
Costa I, Barbosa DJ, Benfeito S, Silva V, Chavarria D, Borges F, Remião F, Silva R. Costa I, et al. Pharmacol Ther. 2023 Apr;244:108373. doi: 10.1016/j.pharmthera.2023.108373. Epub 2023 Mar 8. Pharmacol Ther. 2023. PMID: 36894028 Free article. Review.
On the other side, ferroptosis inhibitors include ferrostatin-1, liproxstatin-1, alpha-tocopherol, zileuton, FSP1, CoQ10 and BH4, which interrupt the lipid peroxidation cascade. ...Increased evidence has established the involvement of ferroptosis in distinct brain d …
On the other side, ferroptosis inhibitors include ferrostatin-1, liproxstatin-1, alpha-tocopherol, zileuton, FSP1, CoQ10 and B …
Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer's disease.
Singh D. Singh D. J Neuroinflammation. 2022 Aug 17;19(1):206. doi: 10.1186/s12974-022-02565-0. J Neuroinflammation. 2022. PMID: 35978311 Free PMC article. Review.
However, chronic or uncontrolled inflammatory responses may lead to various neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, and multiple sclerosis. These diseases have variable cl …
However, chronic or uncontrolled inflammatory responses may lead to various neurodegenerative diseases, including Alzheimer's disease (AD), …
Symptomatic treatments for amyotrophic lateral sclerosis/motor neuron disease.
Ng L, Khan F, Young CA, Galea M. Ng L, et al. Cochrane Database Syst Rev. 2017 Jan 10;1(1):CD011776. doi: 10.1002/14651858.CD011776.pub2. Cochrane Database Syst Rev. 2017. PMID: 28072907 Free PMC article. Review.
BACKGROUND: Motor neuron disease (MND), which is also known as amyotrophic lateral sclerosis (ALS), causes a wide range of symptoms but the evidence base for the effectiveness of the symptomatic treatment therapies is limited. ...Treatment for sialorrhoeaA si …
BACKGROUND: Motor neuron disease (MND), which is also known as amyotrophic lateral sclerosis (ALS), causes a wide range …
Autophagy and ALS: mechanistic insights and therapeutic implications.
Chua JP, De Calbiac H, Kabashi E, Barmada SJ. Chua JP, et al. Autophagy. 2022 Feb;18(2):254-282. doi: 10.1080/15548627.2021.1926656. Epub 2021 May 31. Autophagy. 2022. PMID: 34057020 Free PMC article. Review.
In line with this, mutations in genes that encode essential autophagy factors result in impaired autophagy and lead to neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS). However, the mechanistic details underlying the neuroprotective ro …
In line with this, mutations in genes that encode essential autophagy factors result in impaired autophagy and lead to neurodegenerative con …
cGAS-STING-mediated IFN-I Response in Host Defense and Neuroinflammatory Diseases.
Chen K, Lai C, Su Y, Bao WD, Yang LN, Xu PP, Zhu LQ. Chen K, et al. Curr Neuropharmacol. 2022;20(2):362-371. doi: 10.2174/1570159X19666210924110144. Curr Neuropharmacol. 2022. PMID: 34561985 Free PMC article. Review.
In this review, we will summarize its fundamental roles in initiating host defense against invading pathogens and discuss its pathogenic roles in multiple neuro-inflammatory diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotr …
In this review, we will summarize its fundamental roles in initiating host defense against invading pathogens and discuss its pathogenic rol …
Treatment for sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis.
James E, Ellis C, Brassington R, Sathasivam S, Young CA. James E, et al. Cochrane Database Syst Rev. 2022 May 20;5(5):CD006981. doi: 10.1002/14651858.CD006981.pub3. Cochrane Database Syst Rev. 2022. PMID: 35593746 Free PMC article. Review.
BACKGROUND: Motor neuron disease (MND), also known as amyotrophic lateral sclerosis (ALS), is a progressive neurodegenerative condition that may cause dysphagia, as well as limb weakness, dysarthria, emotional lability, and respiratory failure. ...Mean total …
BACKGROUND: Motor neuron disease (MND), also known as amyotrophic lateral sclerosis (ALS), is a progressive neurodegene …
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Yao RQ, Ren C, Xia ZF, Yao YM. Yao RQ, et al. Autophagy. 2021 Feb;17(2):385-401. doi: 10.1080/15548627.2020.1725377. Epub 2020 Feb 12. Autophagy. 2021. PMID: 32048886 Free PMC article. Review.
Organelle-specific autophagy is one of the major subtypes of autophagy, selectively targeting different organelles for quality control. This type of autophagy includes mitophagy, pexophagy, reticulophagy (endoplasmic reticulum), ribophagy, lysophagy, and nucleophagy. ...In …
Organelle-specific autophagy is one of the major subtypes of autophagy, selectively targeting different organelles for quality control. This …
Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders.
Huang Y, Liu B, Sinha SC, Amin S, Gan L. Huang Y, et al. Mol Neurodegener. 2023 Nov 8;18(1):79. doi: 10.1186/s13024-023-00672-x. Mol Neurodegener. 2023. PMID: 37941028 Free PMC article. Review.
Among the DNA sensors, cyclic GMP-AMP synthase (cGAS) is a primary player in detecting cytosolic DNA, including foreign DNA from pathogens and self-DNA released during cellular damage, culminating in a type I interferon (IFN-I) response through stimulator of interferon gen …
Among the DNA sensors, cyclic GMP-AMP synthase (cGAS) is a primary player in detecting cytosolic DNA, including foreign DNA from pathogens a …
Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome.
Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. Salminen A, et al. Prog Neurobiol. 2013 Jul-Aug;106-107:33-54. doi: 10.1016/j.pneurobio.2013.06.002. Epub 2013 Jul 1. Prog Neurobiol. 2013. PMID: 23827971 Review.
The mechanisms include (i) reduction of Beclin 1 expression or its increased proteolytic cleavage by caspases, (ii) sequestration of Beclin 1 to non-functional locations, such as tau tangles, (iii) formation of inhibitory complexes between Beclin 1 and antiap …
The mechanisms include (i) reduction of Beclin 1 expression or its increased proteolytic cleavage by caspases, (ii) sequestration of …
Amyotrophic lateral sclerosis and agricultural environments: a systematic review.
Kang H, Cha ES, Choi GJ, Lee WJ. Kang H, et al. J Korean Med Sci. 2014 Dec;29(12):1610-7. doi: 10.3346/jkms.2014.29.12.1610. Epub 2014 Nov 21. J Korean Med Sci. 2014. PMID: 25469059 Free PMC article. Review.
The aim of this study was to examine the relationship between the risk of amyotrophic lateral sclerosis (ALS) and exposure to rural environments. ...The risk of ALS was significantly increased with pesticide exposure (OR, 1.44; 95% CI, 1.22-1 …
The aim of this study was to examine the relationship between the risk of amyotrophic lateral sclerosis (ALS) and expos …
240 results