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An approach to using recombinant erythropoietin for neuroprotection in very preterm infants.
Fauchère JC, Dame C, Vonthein R, Koller B, Arri S, Wolf M, Bucher HU. Fauchère JC, et al. Pediatrics. 2008 Aug;122(2):375-82. doi: 10.1542/peds.2007-2591. Pediatrics. 2008. PMID: 18676556 Clinical Trial.
We investigated whether administration of high-dose recombinant human erythropoietin to very preterm infants shortly after birth and subsequently during the first 2 days is safe in terms of short-term outcome. ...CONCLUSIONS: No significant adverse eff …
We investigated whether administration of high-dose recombinant human erythropoietin to very preterm infants sho …
Early High-Dose Erythropoietin and Cognitive Functions of School-Aged Children Born Very Preterm.
Wehrle FM, Held U, Disselhoff V, Schnider B, Stöckli A, Toma M, Bucher HU, Fauchère JC, Natalucci G, Hüppi P, Borradori-Tolsa C, Liverani MC, O'Gorman RL, Latal B, Hagmann CF. Wehrle FM, et al. JAMA Netw Open. 2024 Sep 3;7(9):e2430043. doi: 10.1001/jamanetworkopen.2024.30043. JAMA Netw Open. 2024. PMID: 39254979 Free PMC article.
IMPORTANCE: Children born very preterm are at risk for long-term neurodevelopmental sequelae. Prophylactic high-dose recombinant human erythropoietin (rhEpo) shortly after birth has not been shown to improve cognitive, motor, and behavioral development at 2 a …
IMPORTANCE: Children born very preterm are at risk for long-term neurodevelopmental sequelae. Prophylactic high-dose recombinant …
Neuroprotective potential of erythropoietin in neonates; design of a randomized trial.
Juul SE, Mayock DE, Comstock BA, Heagerty PJ. Juul SE, et al. Matern Health Neonatol Perinatol. 2015 Dec 2;1:27. doi: 10.1186/s40748-015-0028-z. eCollection 2015. Matern Health Neonatol Perinatol. 2015. PMID: 27057344 Free PMC article. Review.
New approaches are needed to improve neonatal outcomes. Recombinant erythropoietin (Epo) is a promising neuroprotective agent that is widely available, affordable, and has been used safely in neonates to stimulate erythropoiesis. ...CONCLUSIONS: Epo …
New approaches are needed to improve neonatal outcomes. Recombinant erythropoietin (Epo) is a promising neuroprotect …