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Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Babon JA, et al. Nat Med. 2016 Dec;22(12):1482-1487. doi: 10.1038/nm.4203. Epub 2016 Oct 31. Nat Med. 2016. PMID: 27798614 Free PMC article.
A major therapeutic goal for type 1 diabetes (T1D) is to induce autoantigen-specific tolerance of T cells. ...Our knowledge of the insulitic T cell repertoire is derived from histological and immunohistochemical analyses of insulit …
A major therapeutic goal for type 1 diabetes (T1D) is to induce autoantigen-specific tolerance of T ce
Human-engineered Treg-like cells suppress FOXP3-deficient T cells but preserve adaptive immune responses in vivo.
Sato Y, Passerini L, Piening BD, Uyeda MJ, Goodwin M, Gregori S, Snyder MP, Bertaina A, Roncarolo MG, Bacchetta R. Sato Y, et al. Clin Transl Immunology. 2020 Nov 25;9(11):e1214. doi: 10.1002/cti2.1214. eCollection 2020. Clin Transl Immunology. 2020. PMID: 33304583 Free PMC article.
Previously, we demonstrated CD4(+) T cells from healthy donors and IPEX patients can be converted into functional Treg-like cells by lentiviral transfer of FOXP3 (CD4(LVFOXP3)). ...CD4(LVFOXP3) cells do not impede in vivo expansion of antigen
Previously, we demonstrated CD4(+) T cells from healthy donors and IPEX patients can be converted into functional Treg- …
Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Babon JA, et al. Nat Med. 2017 Feb 7;23(2):264. doi: 10.1038/nm0217-264a. Nat Med. 2017. PMID: 28170374 No abstract available.
Deciphering the Pathogenesis of Human Type 1 Diabetes (T1D) by Interrogating T Cells from the "Scene of the Crime".
Kent SC, Mannering SI, Michels AW, Babon JAB. Kent SC, et al. Curr Diab Rep. 2017 Sep 2;17(10):95. doi: 10.1007/s11892-017-0915-y. Curr Diab Rep. 2017. PMID: 28864875 Free PMC article. Review.
Now, we are able to examine live, islet-infiltrating T cells from donors with T1D. RECENT FINDINGS: Analysis of the T cell repertoire isolated directly from the pancreatic islets of donors with T1D revealed pro-inflammatory …
Now, we are able to examine live, islet-infiltrating T cells from donors with T1D. RECENT FINDINGS: An
Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Babon JAB, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Babon JAB, et al. Nat Med. 2017 Aug 4;23(8):1004. doi: 10.1038/nm0817-1004a. Nat Med. 2017. PMID: 28777787 Free PMC article. No abstract available.