Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC.
Babon JA, et al.
Nat Med. 2016 Dec;22(12):1482-1487. doi: 10.1038/nm.4203. Epub 2016 Oct 31.
Nat Med. 2016.
PMID: 27798614
Free PMC article.
A major therapeutic goal for type 1 diabetes (T1D) is to induce autoantigen-specific tolerance of T cells. ...Our knowledge of the insulitic T cell repertoire is derived from histological and immunohistochemical analyses of insulit …
A major therapeutic goal for type 1 diabetes (T1D) is to induce autoantigen-specific tolerance of T ce …