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Analysis of ubiquitin E3 ligase activity using selective polyubiquitin binding proteins.
Marblestone JG, Larocque JP, Mattern MR, Leach CA. Marblestone JG, et al. Biochim Biophys Acta. 2012 Nov;1823(11):2094-7. doi: 10.1016/j.bbamcr.2012.06.013. Epub 2012 Jun 18. Biochim Biophys Acta. 2012. PMID: 22721718 Free PMC article.
As researchers continue to characterize E3 ligases, additional associations with various disease states are being exposed. The availability of assays that allow rapid analysis of E3 ligase activity is paramount to both biochemical studies …
As researchers continue to characterize E3 ligases, additional associations with various disease states are being exposed. The …
TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Influenza A Virus Infection.
Patil G, Zhao M, Song K, Hao W, Bouchereau D, Wang L, Li S. Patil G, et al. J Virol. 2018 Jul 31;92(16):e00905-18. doi: 10.1128/JVI.00905-18. Print 2018 Aug 15. J Virol. 2018. PMID: 29899090 Free PMC article.
As a ubiquitin E3 ligase, TRIM41 ubiquitinates NP in vitro and in cells. The TRIM41 mutant lacking E3 ligase activity fails to inhibit IAV infection, suggesting that the E3 ligase activity is indispensable for …
As a ubiquitin E3 ligase, TRIM41 ubiquitinates NP in vitro and in cells. The TRIM41 mutant lacking E3
Data for positive selection test and co-evolutionary analysis on mammalian cereblon.
Onodera W, Asahi T, Sawamura N. Onodera W, et al. Data Brief. 2019 Sep 12;26:104499. doi: 10.1016/j.dib.2019.104499. eCollection 2019 Oct. Data Brief. 2019. PMID: 31667262 Free PMC article.
Cereblon (CRBN) is a substrate recognition subunit of the CRL4 E3 ubiquitin ligase complex, directly binding to specific substrates for poly-ubiquitination followed by proteasome-dependent degradation of proteins. ...Sawamura, Positive …
Cereblon (CRBN) is a substrate recognition subunit of the CRL4 E3 ubiquitin ligase complex, directly binding to …
Nedd4 Deficiency in Vascular Smooth Muscle Promotes Vascular Calcification by Stabilizing pSmad1.
Lee JH, Jeon SA, Kim BG, Takeda M, Cho JJ, Kim DI, Kawabe H, Cho JY. Lee JH, et al. J Bone Miner Res. 2017 May;32(5):927-938. doi: 10.1002/jbmr.3073. Epub 2017 Feb 23. J Bone Miner Res. 2017. PMID: 28029182 Free article.
Also, we identified NEDD4 E3 ligase as a key suppressor of bone morphogenetic protein (BMP)/Smad pathway via a polyubiquitination-dependent selective degradation of C-terminal phosphorylated Smad1 (pSmad1) activated by TGF-β. ...Collectiv …
Also, we identified NEDD4 E3 ligase as a key suppressor of bone morphogenetic protein (BMP)/Smad pathway via a polyu
Stabilization of Notch1 by the Hsp90 Chaperone Is Crucial for T-Cell Leukemogenesis.
Wang Z, Hu Y, Xiao D, Wang J, Liu C, Xu Y, Shi X, Jiang P, Huang L, Li P, Liu H, Qing G. Wang Z, et al. Clin Cancer Res. 2017 Jul 15;23(14):3834-3846. doi: 10.1158/1078-0432.CCR-16-2880. Epub 2017 Jan 31. Clin Cancer Res. 2017. PMID: 28143869 Free article.
The goal of the current study is to identify intracellular Notch1 (ICN1, the activated form of Notch1) binding partner(s) regulating its stability and activity. ...Pharmacologic or short hairpin RNA-mediated inhibition was applied in loss-of-function a …
The goal of the current study is to identify intracellular Notch1 (ICN1, the activated form of Notch1) binding partner(s
The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization.
Leslie PL, Ke H, Zhang Y. Leslie PL, et al. J Biol Chem. 2015 May 15;290(20):12941-50. doi: 10.1074/jbc.M115.644435. Epub 2015 Mar 25. J Biol Chem. 2015. PMID: 25809483 Free PMC article.
The oncoprotein murine double minute 2 (MDM2) is an E3 ligase that plays a prominent role in p53 suppression by promoting its polyubiquitination and proteasomal degradation. ...Intriguingly, deletion of a portion of the MDM2 central acidic domain selective
The oncoprotein murine double minute 2 (MDM2) is an E3 ligase that plays a prominent role in p53 suppression by promoting its …
A regulatory loop composed of RAP80-HDM2-p53 provides RAP80-enhanced p53 degradation by HDM2 in response to DNA damage.
Yan J, Menendez D, Yang XP, Resnick MA, Jetten AM. Yan J, et al. J Biol Chem. 2009 Jul 17;284(29):19280-9. doi: 10.1074/jbc.M109.013102. Epub 2009 May 11. J Biol Chem. 2009. PMID: 19433585 Free PMC article.
The ubiquitin interaction motif-containing protein RAP80 plays a key role in DNA damage response signaling. Using genomic and functional analysis, we established that the expression of the RAP80 gene is regulated in a DNA damage-responsive manner by the maste …
The ubiquitin interaction motif-containing protein RAP80 plays a key role in DNA damage response signaling. Using genomic and …
Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation.
Liu J, Zhao Y, Eilers M, Lin A. Liu J, et al. Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18279-84. doi: 10.1073/pnas.0906328106. Epub 2009 Oct 7. Proc Natl Acad Sci U S A. 2009. PMID: 19815509 Free PMC article.
Here, we report that the transcription factor Myc-interacting zinc-finger protein 1 (Miz1) selectively suppresses TNF-alpha-induced JNK1 activation and cell death independently of its transcription activity. Proteomics analysis and yeast two-hyb …
Here, we report that the transcription factor Myc-interacting zinc-finger protein 1 (Miz1) selectively suppresses TNF-alpha-in …
Glycogen synthase kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells.
Sarshad AA, Corcoran M, Al-Muzzaini B, Borgonovo-Brandter L, Von Euler A, Lamont D, Visa N, Percipalle P. Sarshad AA, et al. PLoS Genet. 2014 Jun 5;10(6):e1004390. doi: 10.1371/journal.pgen.1004390. eCollection 2014 Jun. PLoS Genet. 2014. PMID: 24901984 Free PMC article.
Genomic analysis by ChIP-Seq showed that this mechanism occurs on the rDNA as active GSK3β selectively occupies the gene. ChIP assays and transmission electron microscopy in GSK3β-/- mouse embryonic fibroblasts indicated that at G1 rRNA synthesis is suppresse …
Genomic analysis by ChIP-Seq showed that this mechanism occurs on the rDNA as active GSK3β selectively occupies the gen …
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