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Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells.
Harikumar KB, Kunnumakkara AB, Ahn KS, Anand P, Krishnan S, Guha S, Aggarwal BB. Harikumar KB, et al. Among authors: anand p. Blood. 2009 Feb 26;113(9):2003-13. doi: 10.1182/blood-2008-04-151944. Epub 2008 Oct 24. Blood. 2009. PMID: 18952893 Free PMC article.
Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis.
Kunnumakkara AB, Ichikawa H, Anand P, Mohankumar CJ, Hema PS, Nair MS, Aggarwal BB. Kunnumakkara AB, et al. Among authors: anand p. Mol Cancer Ther. 2008 Oct;7(10):3306-17. doi: 10.1158/1535-7163.MCT-08-0432. Mol Cancer Ther. 2008. PMID: 18852134 Retracted.
Cancer is a preventable disease that requires major lifestyle changes.
Anand P, Kunnumakkara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Sung B, Aggarwal BB. Anand P, et al. Pharm Res. 2008 Sep;25(9):2097-116. doi: 10.1007/s11095-008-9661-9. Epub 2008 Jul 15. Pharm Res. 2008. PMID: 18626751 Free PMC article. Review.
735 results