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Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins.
Kunnumakkara AB, Anand P, Aggarwal BB. Kunnumakkara AB, et al. Among authors: anand p. Cancer Lett. 2008 Oct 8;269(2):199-225. doi: 10.1016/j.canlet.2008.03.009. Epub 2008 May 13. Cancer Lett. 2008. PMID: 18479807 Review.
Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer.
Harikumar KB, Kunnumakkara AB, Sethi G, Diagaradjane P, Anand P, Pandey MK, Gelovani J, Krishnan S, Guha S, Aggarwal BB. Harikumar KB, et al. Among authors: anand p. Int J Cancer. 2010 Jul 15;127(2):257-68. doi: 10.1002/ijc.25041. Int J Cancer. 2010. PMID: 19908231 Free PMC article.

In an orthotopic model of human PaCa, we found that resveratrol significantly suppressed the growth of the tumor (p < 0.001) and this effect was further enhanced by gemcitabine (p < 0.001). Both the markers of proliferation index Ki-67 and the micro vessel den

In an orthotopic model of human PaCa, we found that resveratrol significantly suppressed the growth of the tumor (p < 0.001) and t

Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo.
Anand P, Nair HB, Sung B, Kunnumakkara AB, Yadav VR, Tekmal RR, Aggarwal BB. Anand P, et al. Biochem Pharmacol. 2010 Feb 1;79(3):330-8. doi: 10.1016/j.bcp.2009.09.003. Epub 2009 Sep 6. Biochem Pharmacol. 2010. PMID: 19735646 Free PMC article. Retracted.
Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.
Kunnumakkara AB, Diagaradjane P, Anand P, Harikumar KB, Deorukhkar A, Gelovani J, Guha S, Krishnan S, Aggarwal BB. Kunnumakkara AB, et al. Among authors: anand p. Int J Cancer. 2009 Nov 1;125(9):2187-97. doi: 10.1002/ijc.24593. Int J Cancer. 2009. PMID: 19623659
In nude mice, the combination of curcumin and capecitabine was found to be more effective than either agent alone in reducing tumor volume (p = 0.001 vs. control; p = 0.031 vs. capecitabine alone), Ki-67 proliferation index (p = 0.001 vs. control) and microve …
In nude mice, the combination of curcumin and capecitabine was found to be more effective than either agent alone in reducing tumor volume ( …
Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model.
Sung B, Kunnumakkara AB, Sethi G, Anand P, Guha S, Aggarwal BB. Sung B, et al. Among authors: anand p. Mol Cancer Ther. 2009 Apr;8(4):959-70. doi: 10.1158/1535-7163.MCT-08-0905. Mol Cancer Ther. 2009. PMID: 19372569 Free PMC article.
Furthermore, in a nude mice model, we found that curcumin potentiated the antitumor effects of bortezomib (P<0.001, vehicle versus bortezomib+curcumin; P<0.001, bortezomib versus bortezomib+curcumin), and this correlated with suppression of Ki-67 (P< …
Furthermore, in a nude mice model, we found that curcumin potentiated the antitumor effects of bortezomib (P<0.001, vehicle versus …
Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis.
Anand P, Kunnumakkara AB, Harikumar KB, Ahn KS, Badmaev V, Aggarwal BB. Anand P, et al. Cancer Res. 2008 Nov 1;68(21):8861-70. doi: 10.1158/0008-5472.CAN-08-1902. Cancer Res. 2008. PMID: 18974130 Free PMC article. Retracted.
Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells.
Harikumar KB, Kunnumakkara AB, Ahn KS, Anand P, Krishnan S, Guha S, Aggarwal BB. Harikumar KB, et al. Among authors: anand p. Blood. 2009 Feb 26;113(9):2003-13. doi: 10.1182/blood-2008-04-151944. Epub 2008 Oct 24. Blood. 2009. PMID: 18952893 Free PMC article.
Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis.
Kunnumakkara AB, Ichikawa H, Anand P, Mohankumar CJ, Hema PS, Nair MS, Aggarwal BB. Kunnumakkara AB, et al. Among authors: anand p. Mol Cancer Ther. 2008 Oct;7(10):3306-17. doi: 10.1158/1535-7163.MCT-08-0432. Mol Cancer Ther. 2008. PMID: 18852134 Retracted.
Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.
Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B, Tharakan ST, Misra K, Priyadarsini IK, Rajasekharan KN, Aggarwal BB. Anand P, et al. Biochem Pharmacol. 2008 Dec 1;76(11):1590-611. doi: 10.1016/j.bcp.2008.08.008. Epub 2008 Aug 19. Biochem Pharmacol. 2008. PMID: 18775680 Review.
Cancer is a preventable disease that requires major lifestyle changes.
Anand P, Kunnumakkara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Sung B, Aggarwal BB. Anand P, et al. Pharm Res. 2008 Sep;25(9):2097-116. doi: 10.1007/s11095-008-9661-9. Epub 2008 Jul 15. Pharm Res. 2008. PMID: 18626751 Free PMC article. Review.
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