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Recent advances in the medicinal chemistry of polyamine toxins.
Strømgaard K, Andersen K, Krogsgaard-Larsen P, Jaroszewski JW. Strømgaard K, et al. Mini Rev Med Chem. 2001 Nov;1(4):317-38. doi: 10.2174/1389557013406738. Mini Rev Med Chem. 2001. PMID: 12369960 Review.
Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues.
Strømgaard K, Brier TJ, Andersen K, Mellor IR, Saghyan A, Tikhonov D, Usherwood PN, Krogsgaard-Larsen P, Jaroszewski JW. Strømgaard K, et al. J Med Chem. 2000 Nov 16;43(23):4526-33. doi: 10.1021/jm000220n. J Med Chem. 2000. PMID: 11087577
Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor.
Stromgaard K, Brierley MJ, Andersen K, Sløk FA, Mellor IR, Usherwood PN, Krogsgaard-Larsen P, Jaroszewski JW. Stromgaard K, et al. J Med Chem. 1999 Dec 16;42(25):5224-34. doi: 10.1021/jm9903747. J Med Chem. 1999. PMID: 10602707
Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole.
Andersen K, Liljefors T, Hyttel J, Perregaard J. Andersen K, et al. J Med Chem. 1996 Sep 13;39(19):3723-38. doi: 10.1021/jm960159f. J Med Chem. 1996. PMID: 8809161
Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors.
Andersen K, Liljefors T, Gundertofte K, Perregaard J, Bøgesø KP. Andersen K, et al. J Med Chem. 1994 Apr 1;37(7):950-62. doi: 10.1021/jm00033a013. J Med Chem. 1994. PMID: 8151622
Thioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasome.
Andersen KM, Madsen L, Prag S, Johnsen AH, Semple CA, Hendil KB, Hartmann-Petersen R. Andersen KM, et al. J Biol Chem. 2009 May 29;284(22):15246-54. doi: 10.1074/jbc.M900016200. Epub 2009 Apr 6. J Biol Chem. 2009. PMID: 19349277 Free PMC article.
Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12.
Strømgaard K, Bjørnsdottir I, Andersen K, Brierley MJ, Rizoli S, Eldursi N, Mellor IR, Usherwood PN, Hansen SH, Krogsgaard-Larsen P, Jaroszewski JW. Strømgaard K, et al. Chirality. 2000 Feb;12(2):93-102. doi: 10.1002/(SICI)1520-636X(2000)12:2<93::AID-CHIR6>3.0.CO;2-B. Chirality. 2000. PMID: 10637415
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