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Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities.
Li XQ, Andersson TB, Ahlström M, Weidolf L. Li XQ, et al. Drug Metab Dispos. 2004 Aug;32(8):821-7. doi: 10.1124/dmd.32.8.821. Drug Metab Dispos. 2004. PMID: 15258107
Evaluation of the pharmacodynamics of acetylsalicylic acid 81 mg with or without esomeprazole 20 mg in healthy volunteers.
Andersson T, Morrison D, Nagy P, Pisupati J, Schettler J, Warner TD. Andersson T, et al. Am J Cardiovasc Drugs. 2012 Aug 1;12(4):217-24. doi: 10.1007/BF03261830. Am J Cardiovasc Drugs. 2012. PMID: 22631032 Clinical Trial.
Effect of esomeprazole with/without acetylsalicylic acid, omeprazole and lansoprazole on pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers.
Andersson T, Nagy P, Niazi M, Nylander S, Galbraith H, Ranjan S, Wallentin L. Andersson T, et al. Am J Cardiovasc Drugs. 2014 Jun;14(3):217-27. doi: 10.1007/s40256-014-0073-4. Am J Cardiovasc Drugs. 2014. PMID: 24677117 Clinical Trial.
In vitro evaluation of major in vivo drug metabolic pathways using primary human hepatocytes and HepaRG cells in suspension and a dynamic three-dimensional bioreactor system.
Darnell M, Ulvestad M, Ellis E, Weidolf L, Andersson TB. Darnell M, et al. J Pharmacol Exp Ther. 2012 Oct;343(1):134-44. doi: 10.1124/jpet.112.195834. Epub 2012 Jul 9. J Pharmacol Exp Ther. 2012. PMID: 22776955
Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells.
Ulvestad M, Nordell P, Asplund A, Rehnström M, Jacobsson S, Holmgren G, Davidson L, Brolén G, Edsbagge J, Björquist P, Küppers-Munther B, Andersson TB. Ulvestad M, et al. Biochem Pharmacol. 2013 Sep 1;86(5):691-702. doi: 10.1016/j.bcp.2013.06.029. Epub 2013 Jul 12. Biochem Pharmacol. 2013. PMID: 23856292
Cytochrome P450-dependent metabolism in HepaRG cells cultured in a dynamic three-dimensional bioreactor.
Darnell M, Schreiter T, Zeilinger K, Urbaniak T, Söderdahl T, Rossberg I, Dillnér B, Berg AL, Gerlach JC, Andersson TB. Darnell M, et al. Drug Metab Dispos. 2011 Jul;39(7):1131-8. doi: 10.1124/dmd.110.037721. Epub 2011 Mar 24. Drug Metab Dispos. 2011. PMID: 21436404
Evaluation of organic anion-transporting polypeptide 1B1 and CYP3A4 activities in primary human hepatocytes and HepaRG cells cultured in a dynamic three-dimensional bioreactor system.
Ulvestad M, Darnell M, Molden E, Ellis E, Åsberg A, Andersson TB. Ulvestad M, et al. J Pharmacol Exp Ther. 2012 Oct;343(1):145-56. doi: 10.1124/jpet.112.195750. Epub 2012 Jul 12. J Pharmacol Exp Ther. 2012. PMID: 22789711
The HepaRG cell line: a unique in vitro tool for understanding drug metabolism and toxicology in human.
Andersson TB, Kanebratt KP, Kenna JG. Andersson TB, et al. Expert Opin Drug Metab Toxicol. 2012 Jul;8(7):909-20. doi: 10.1517/17425255.2012.685159. Epub 2012 May 8. Expert Opin Drug Metab Toxicol. 2012. PMID: 22568886 Review.
Ximelagatran, an oral direct thrombin inhibitor, has a low potential for cytochrome P450-mediated drug-drug interactions.
Bredberg E, Andersson TB, Frison L, Thuresson A, Johansson S, Eriksson-Lepkowska M, Larsson M, Eriksson UG. Bredberg E, et al. Clin Pharmacokinet. 2003;42(8):765-77. doi: 10.2165/00003088-200342080-00005. Clin Pharmacokinet. 2003. PMID: 12846597 Clinical Trial.
Development of a highly sensitive method using liquid chromatography-multiple reaction monitoring to quantify membrane P-glycoprotein in biological matrices and relationship to transport function.
Miliotis T, Ali L, Palm JE, Lundqvist AJ, Ahnoff M, Andersson TB, Hilgendorf C. Miliotis T, et al. Drug Metab Dispos. 2011 Dec;39(12):2440-9. doi: 10.1124/dmd.111.040774. Epub 2011 Sep 23. Drug Metab Dispos. 2011. PMID: 21949244
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