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Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression.
Weiss A, Träger U, Wild EJ, Grueninger S, Farmer R, Landles C, Scahill RI, Lahiri N, Haider S, Macdonald D, Frost C, Bates GP, Bilbe G, Kuhn R, Andre R, Tabrizi SJ. Weiss A, et al. Among authors: andre r. J Clin Invest. 2012 Oct;122(10):3731-6. doi: 10.1172/JCI64565. Epub 2012 Sep 17. J Clin Invest. 2012. PMID: 22996692 Free PMC article.
Mutant huntingtin impairs immune cell migration in Huntington disease.
Kwan W, Träger U, Davalos D, Chou A, Bouchard J, Andre R, Miller A, Weiss A, Giorgini F, Cheah C, Möller T, Stella N, Akassoglou K, Tabrizi SJ, Muchowski PJ. Kwan W, et al. Among authors: andre r. J Clin Invest. 2012 Dec;122(12):4737-47. doi: 10.1172/JCI64484. Epub 2012 Nov 19. J Clin Invest. 2012. PMID: 23160193 Free PMC article.
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease.
Björkqvist M, Wild EJ, Thiele J, Silvestroni A, Andre R, Lahiri N, Raibon E, Lee RV, Benn CL, Soulet D, Magnusson A, Woodman B, Landles C, Pouladi MA, Hayden MR, Khalili-Shirazi A, Lowdell MW, Brundin P, Bates GP, Leavitt BR, Möller T, Tabrizi SJ. Björkqvist M, et al. Among authors: andre r. J Exp Med. 2008 Aug 4;205(8):1869-77. doi: 10.1084/jem.20080178. Epub 2008 Jul 14. J Exp Med. 2008. PMID: 18625748 Free PMC article.
Huntington's disease: fighting on many fronts.
Andre R, Wild EJ, Tabrizi SJ. Andre R, et al. Brain. 2012 Apr;135(Pt 4):998-1001. doi: 10.1093/brain/aws060. Epub 2012 Mar 16. Brain. 2012. PMID: 22427330 No abstract available.
HTT-lowering reverses Huntington's disease immune dysfunction caused by NFκB pathway dysregulation.
Träger U, Andre R, Lahiri N, Magnusson-Lind A, Weiss A, Grueninger S, McKinnon C, Sirinathsinghji E, Kahlon S, Pfister EL, Moser R, Hummerich H, Antoniou M, Bates GP, Luthi-Carter R, Lowdell MW, Björkqvist M, Ostroff GR, Aronin N, Tabrizi SJ. Träger U, et al. Among authors: andre r. Brain. 2014 Mar;137(Pt 3):819-33. doi: 10.1093/brain/awt355. Epub 2014 Jan 22. Brain. 2014. PMID: 24459107 Free PMC article.
Biomarker development for Huntington's disease.
Andre R, Scahill RI, Haider S, Tabrizi SJ. Andre R, et al. Drug Discov Today. 2014 Jul;19(7):972-9. doi: 10.1016/j.drudis.2014.03.002. Epub 2014 Mar 12. Drug Discov Today. 2014. PMID: 24632006 Review.
A critical evaluation of inflammatory markers in Huntington's Disease plasma.
Silajdžić E, Rezeli M, Végvári Á, Lahiri N, Andre R, Magnusson-Lind A, Nambron R, Kalliolia E, Marko-Varga G, Warner TT, Laurell T, Tabrizi SJ, Björkqvist M. Silajdžić E, et al. Among authors: andre r. J Huntingtons Dis. 2013;2(1):125-34. doi: 10.3233/JHD-130049. J Huntingtons Dis. 2013. PMID: 25063434
450 results