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Page 1
A nut-and-bolt assembly of the bimodular large progenitor botulinum neurotoxin complex.
Lam KH, Gao L, Przykopanski A, Chen B, Huang T, Krüger M, Bartels AM, Dorner MB, Perry K, Dorner BG, Rummel A, Jin R. Lam KH, et al. Among authors: rummel a. Sci Adv. 2025 Aug 29;11(35):eadx5831. doi: 10.1126/sciadv.adx5831. Epub 2025 Aug 27. Sci Adv. 2025. PMID: 40864694 Free PMC article.
Botulinum neurotoxin serotype A (BoNT/A) is naturally produced by bacteria along with four nontoxic neurotoxin-associated proteins (NTNH, HA70, HA33, and HA17), forming a bimodular large progenitor toxin complex (L-PTC). The BoNT/A-NTNH complex protects the toxin fr …
Botulinum neurotoxin serotype A (BoNT/A) is naturally produced by bacteria along with four nontoxic neurotoxin-associated proteins (NTNH, HA …
Highly Sensitive Suspension Immunoassay for Multiplex Detection, Differentiation, and Quantification of Eight Staphylococcus aureus Enterotoxins (SEA to SEI).
Dettmann P, Skiba M, Stern D, Weisemann J, Mages HW, Krez N, Dorner MB, Schaarschmidt S, Avondet MA, Fulde M, Rummel A, Strommenger B, Maurischat S, Dorner BG. Dettmann P, et al. Among authors: rummel a. Toxins (Basel). 2025 May 24;17(6):265. doi: 10.3390/toxins17060265. Toxins (Basel). 2025. PMID: 40559843 Free PMC article.
Reliable detection methods for SEs are essential to maintain food safety and protect public health. Since the heat-stable toxins also exert their toxic effect in the absence of the bacterium, reliance on DNA detection alone can be misleading: it does not allow for determin …
Reliable detection methods for SEs are essential to maintain food safety and protect public health. Since the heat-stable toxins also …
Botulinum neurotoxin A mutants with enhanced ganglioside binding show improved potency and altered ganglioside selectivity.
Masuyer G, Rummel A, Stenmark P. Masuyer G, et al. Among authors: rummel a. Commun Chem. 2025 Jun 4;8(1):171. doi: 10.1038/s42004-025-01569-0. Commun Chem. 2025. PMID: 40467754 Free PMC article.
Botulinum neurotoxins are the causative agents of botulism, a lethal paralytic disease, but are also one of the most commonly used therapeutics for the treatment of numerous neuromuscular conditions. These toxins recognise motor nerve terminals with high specificity and af …
Botulinum neurotoxins are the causative agents of botulism, a lethal paralytic disease, but are also one of the most commonly used therapeut …
Validation of an Endopep-suspension immunoassay for the diagnostics of human botulism.
Steinberg M, Wilk LV, Stern D, Weisemann J, Messelhäußer U, Wittwer M, Krüger M, Mages HW, Rummel A, Dorner MB, Dorner BG. Steinberg M, et al. Among authors: rummel a. ALTEX. 2025;42(4):636-656. doi: 10.14573/altex.2412181. Epub 2025 May 19. ALTEX. 2025. PMID: 40396553 Free article.
This medical emergency requires rapid testing and laboratory confirmation of toxin presence in patient samples such as blood. Historically, mice are injected with sample material and observed for onset of disease symptoms. ...
This medical emergency requires rapid testing and laboratory confirmation of toxin presence in patient samples such as blood. Histori …
N-Glycosylation Profile of Abrin Certified EU Reference Material.
Josuran R, Wenger A, Worbs S, Kampa B, Rummel A, Dorner BG, Gerber S. Josuran R, et al. Among authors: rummel a. Toxins (Basel). 2025 Feb 26;17(3):108. doi: 10.3390/toxins17030108. Toxins (Basel). 2025. PMID: 40137881 Free PMC article.
In conclusion, the abrin N-glycosylation profile is highly similar to the one of ricin and yields high analytical value to be further exploited as a fingerprint in forensic investigations to uncover toxin production or toxin provenance....
In conclusion, the abrin N-glycosylation profile is highly similar to the one of ricin and yields high analytical value to be further exploi …
Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47.
Gao L, Nowakowska MB, Selby K, Przykopanski A, Chen B, Krüger M, Douillard FP, Lam KH, Chen P, Huang T, Minton NP, Dorner MB, Dorner BG, Rummel A, Lindström M, Jin R. Gao L, et al. Among authors: rummel a. Nat Struct Mol Biol. 2025 May;32(5):864-875. doi: 10.1038/s41594-024-01479-0. Epub 2025 Jan 21. Nat Struct Mol Biol. 2025. PMID: 39838108 Free PMC article.
Botulinum neurotoxins (BoNTs) rank among the most potent toxins and many of them are produced by bacteria carrying the orfX gene cluster that also encodes four nontoxic proteins (OrfX1, OrfX2, OrfX3 and P47). The orfX gene cluster is also found in the genomes of many non-B …
Botulinum neurotoxins (BoNTs) rank among the most potent toxins and many of them are produced by bacteria carrying the orfX gene clus …
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry.
Joensuu M, Syed P, Saber SH, Lanoue V, Wallis TP, Rae J, Blum A, Gormal RS, Small C, Sanders S, Jiang A, Mahrhold S, Krez N, Cousin MA, Cooper-White R, Cooper-White JJ, Collins BM, Parton RG, Balistreri G, Rummel A, Meunier FA. Joensuu M, et al. Among authors: rummel a. EMBO J. 2023 Jul 3;42(13):e112095. doi: 10.15252/embj.2022112095. Epub 2023 May 25. EMBO J. 2023. PMID: 37226896 Free PMC article.
We reveal that BoNT/A simultaneously interacts with a preassembled PSG-synaptotagmin-1 (Syt1) complex and SV2 on the neuronal plasma membrane, facilitating Syt1-SV2 nanoclustering that controls endocytic sorting of the toxin into synaptic vesicles. Syt1 CRISPRi knockdown s …
We reveal that BoNT/A simultaneously interacts with a preassembled PSG-synaptotagmin-1 (Syt1) complex and SV2 on the neuronal plasma membran …
Crystal structures of OrfX1, OrfX2 and the OrfX1-OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1.
Gao L, Lam KH, Liu S, Przykopanski A, Lübke J, Qi R, Krüger M, Nowakowska MB, Selby K, Douillard FP, Dorner MB, Perry K, Lindström M, Dorner BG, Rummel A, Jin R. Gao L, et al. Among authors: rummel a. FEBS Lett. 2023 Feb;597(4):524-537. doi: 10.1002/1873-3468.14576. Epub 2023 Jan 27. FEBS Lett. 2023. PMID: 36653893 Free PMC article.
Botulinum neurotoxins (BoNTs) are among the most lethal toxins known to humans, comprising seven established serotypes termed BoNT/A-G encoded in two types of gene clusters (ha and orfX) in BoNT-producing clostridia. ...
Botulinum neurotoxins (BoNTs) are among the most lethal toxins known to humans, comprising seven established serotypes termed BoNT/A- …
Construction and validation of safe Clostridium botulinum Group II surrogate strain producing inactive botulinum neurotoxin type E toxoid.
Nowakowska MB, Selby K, Przykopanski A, Krüger M, Krez N, Dorner BG, Dorner MB, Jin R, Minton NP, Rummel A, Lindström M. Nowakowska MB, et al. Among authors: rummel a. Sci Rep. 2022 Feb 2;12(1):1790. doi: 10.1038/s41598-022-05008-1. Sci Rep. 2022. PMID: 35110559 Free PMC article.
Nevertheless, as the most potent natural toxin, BoNT is classified as a Select Agent in the US, placing C. botulinum research under stringent governmental regulations. ...The resulting Beluga Ei strain displays unchanged physiology and produces inactive BoNT (BoNT/Ei) reco …
Nevertheless, as the most potent natural toxin, BoNT is classified as a Select Agent in the US, placing C. botulinum research under s …
70 results