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The stenlying effect of high hydrostatic pressure on thermally and hydrolytically labile nanosized carriers.
Brigger I, Armand-Lefevre L, Chaminade P, Besnard M, Rigaldie Y, Largeteau A, Andremont A, Grislain L, Demazeau G, Couvreur P. Brigger I, et al. Pharm Res. 2003 Apr;20(4):674-83. doi: 10.1023/a:1023267304096. Pharm Res. 2003. PMID: 12739778
A sterility test also conducted according to pharmacopoeial requirements on an importantly contaminated nanoparticle suspension. ...However, precautions should be taken when surface modifiers are adsorbed onto nanoparticles, as a layer destabilization may occur. ...
A sterility test also conducted according to pharmacopoeial requirements on an importantly contaminated nanoparticle suspension. ...H
Colonic delivery of beta-lactamases does not affect amoxicillin pharmacokinetics in rats.
Bourgeois S, Tsapis N, Honnas H, Andremont A, Shakweh M, Besnard M, Fattal E. Bourgeois S, et al. J Pharm Sci. 2008 May;97(5):1853-63. doi: 10.1002/jps.21115. J Pharm Sci. 2008. PMID: 17803197
Particle characterization showed that dried beads had a diameter around 1 mm independently of the presence of PEI. Seven to ten percent (w/w) of PEI was located on bead surface forming a coating layer as observed by scanning electron microscopy. ...In conclusion, PE …
Particle characterization showed that dried beads had a diameter around 1 mm independently of the presence of PEI. Seven to ten perce …
In vitro and in vivo evaluation of pectin beads for the colon delivery of beta-lactamases.
Bourgeois S, Laham A, Besnard M, Andremont A, Fattal E. Bourgeois S, et al. J Drug Target. 2005 Jun;13(5):277-84. doi: 10.1080/10611860500206583. J Drug Target. 2005. PMID: 16199371
Pectin beads were prepared according to ionotropic gelation method using CaCl2 as a gelling agent. Particles were then washed and soaked in polyethylenimine (PEI). ...This study demonstrates that a multiparticulate system with suitable characteristics for site-speci …
Pectin beads were prepared according to ionotropic gelation method using CaCl2 as a gelling agent. Particles were then washed and soa …
Drug targeting by polyalkylcyanoacrylate nanoparticles is not efficient against persistent Salmonella.
Page-Clisson ME, Pinto-Alphandary H, Chachaty E, Couvreur P, Andremont A. Page-Clisson ME, et al. Pharm Res. 1998 Apr;15(4):544-9. doi: 10.1023/a:1011921608964. Pharm Res. 1998. PMID: 9587949
METHODS: A model of persistent S. typhimurium infection was developed in C57BL/6 mice using i.v. inoculation of the plasmid-cured strain C53. RESULTS: In vivo and ex vivo experiments showed that the persisting bacteria seem to evolve to a nongrowing state during exp …
METHODS: A model of persistent S. typhimurium infection was developed in C57BL/6 mice using i.v. inoculation of the plasmid-cured str …
Intracellular distribution of ampicillin in murine macrophages infected with Salmonella typhimurium and treated with (3H)ampicillin-loaded nanoparticles.
Balland O, Pinto-Alphandary H, Viron A, Puvion E, Andremont A, Couvreur P. Balland O, et al. J Antimicrob Chemother. 1996 Jan;37(1):105-15. doi: 10.1093/jac/37.1.105. J Antimicrob Chemother. 1996. PMID: 8647751
Intracellular visualization of ampicillin-loaded nanoparticles in peritoneal macrophages infected in vitro with Salmonella typhimurium.
Pinto-Alphandary H, Balland O, Laurent M, Andremont A, Puisieux F, Couvreur P. Pinto-Alphandary H, et al. Pharm Res. 1994 Jan;11(1):38-46. doi: 10.1023/a:1018985308984. Pharm Res. 1994. PMID: 8140054
Consequently, ampicillin, which usually penetrates into cells at a low level, is directly carried in, when loaded on nanoparticles, and brought into contact with intracellular bacteria....
Consequently, ampicillin, which usually penetrates into cells at a low level, is directly carried in, when loaded on nanoparticles, a …
Treatment of experimental salmonellosis in mice with ampicillin-bound nanoparticles.
Fattal E, Youssef M, Couvreur P, Andremont A. Fattal E, et al. Antimicrob Agents Chemother. 1989 Sep;33(9):1540-3. doi: 10.1128/aac.33.9.1540. Antimicrob Agents Chemother. 1989. PMID: 2684009 Free PMC article.
By contrast, all mice treated with a single injection of 0.8 mg of nanoparticle-bound ampicillin survived. With free ampicillin, a similar curative effect required three doses of 32 mg each. ...
By contrast, all mice treated with a single injection of 0.8 mg of nanoparticle-bound ampicillin survived. With free ampicillin, a
Liposome-entrapped ampicillin in the treatment of experimental murine listeriosis and salmonellosis.
Fattal E, Rojas J, Youssef M, Couvreur P, Andremont A. Fattal E, et al. Antimicrob Agents Chemother. 1991 Apr;35(4):770-2. doi: 10.1128/aac.35.4.770. Antimicrob Agents Chemother. 1991. PMID: 2069386 Free PMC article.
Tancrède, A. Omnès, P. Couvreur, and A. Andremont, Antimicrob. Agents Chemother. 32:1204-1207, 1988) in targeting ampicillin to the spleen but were less effective than nanoparticles in targeting ampicillin to the liver and reducing mortality in acute salmonel …
Tancrède, A. Omnès, P. Couvreur, and A. Andremont, Antimicrob. Agents Chemother. 32:1204-1207, 1988) in targeting ampic …
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