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ZN148 Is a Modular Synthetic Metallo-β-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo.
Samuelsen Ø, Åstrand OAH, Fröhlich C, Heikal A, Skagseth S, Carlsen TJO, Leiros HS, Bayer A, Schnaars C, Kildahl-Andersen G, Lauksund S, Finke S, Huber S, Gjøen T, Andresen AMS, Økstad OA, Rongved P. Samuelsen Ø, et al. Among authors: andresen ams. Antimicrob Agents Chemother. 2020 May 21;64(6):e02415-19. doi: 10.1128/AAC.02415-19. Print 2020 May 21. Antimicrob Agents Chemother. 2020. PMID: 32179522 Free PMC article.
Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors.
Kildahl-Andersen G, Schnaars C, Prandina A, Radix S, Le Borgne M, Jordheim LP, Gjøen T, Andresen AMS, Lauksund S, Fröhlich C, Samuelsen Ø, Rongved P, Åstrand OAH. Kildahl-Andersen G, et al. Among authors: andresen ams. Medchemcomm. 2019 Mar 8;10(4):528-537. doi: 10.1039/c8md00578h. eCollection 2019 Apr 1. Medchemcomm. 2019. PMID: 31057732 Free PMC article.
Synthesis and Preclinical Evaluation of TPA-Based Zinc Chelators as Metallo-β-lactamase Inhibitors.
Schnaars C, Kildahl-Andersen G, Prandina A, Popal R, Radix S, Le Borgne M, Gjøen T, Andresen AMS, Heikal A, Økstad OA, Fröhlich C, Samuelsen Ø, Lauksund S, Jordheim LP, Rongved P, Åstrand OAH. Schnaars C, et al. Among authors: andresen ams. ACS Infect Dis. 2018 Sep 14;4(9):1407-1422. doi: 10.1021/acsinfecdis.8b00137. Epub 2018 Aug 2. ACS Infect Dis. 2018. PMID: 30022668