Andrew S. Thompson[Author] - Search Results

Year	Number of Results
1996	1
1999	1
2002	1
2003	2
2004	1
2007	2
2008	1
2009	1
2010	1
2011	7
2013	3
2015	3
2016	1
2023	0

1

Design and Discovery of 2-Arylquinazolin-4-ones as Potent and Selective Inhibitors of Tankyrases.

Nathubhai A, Wood PJ, Lloyd MD, Thompson AS, Threadgill MD. Nathubhai A, et al. Among authors: thompson as. ACS Med Chem Lett. 2013 Oct 15;4(12):1173-7. doi: 10.1021/ml400260b. eCollection 2013 Dec 12. ACS Med Chem Lett. 2013. PMID: 24900625 Free PMC article.

2

Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases.

Nathubhai A, Haikarainen T, Hayward PC, Muñoz-Descalzo S, Thompson AS, Lloyd MD, Lehtiö L, Threadgill MD. Nathubhai A, et al. Among authors: thompson as. Eur J Med Chem. 2016 Aug 8;118:316-27. doi: 10.1016/j.ejmech.2016.04.041. Epub 2016 Apr 20. Eur J Med Chem. 2016. PMID: 27163581

3

Initial development of a cytotoxic amino-seco-CBI warhead for delivery by prodrug systems.

Twum EA, Nathubhai A, Wood PJ, Lloyd MD, Thompson AS, Threadgill MD. Twum EA, et al. Among authors: thompson as. Bioorg Med Chem. 2015 Jul 1;23(13):3481-9. doi: 10.1016/j.bmc.2015.04.034. Epub 2015 Apr 17. Bioorg Med Chem. 2015. PMID: 25963825

4

5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2).

Sunderland PT, Woon EC, Dhami A, Bergin AB, Mahon MF, Wood PJ, Jones LA, Tully SR, Lloyd MD, Thompson AS, Javaid H, Martin NM, Threadgill MD. Sunderland PT, et al. Among authors: thompson as. J Med Chem. 2011 Apr 14;54(7):2049-59. doi: 10.1021/jm1010918. Epub 2011 Mar 18. J Med Chem. 2011. PMID: 21417348 Free article.

5

Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1.

Holbourn KP, Lloyd MD, Thompson AS, Threadgill MD, Acharya KR. Holbourn KP, et al. Among authors: thompson as. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1;67(Pt 4):461-3. doi: 10.1107/S1744309111003277. Epub 2011 Mar 25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 21505241 Free PMC article.

6

One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs.

Woon EC, Sunderland PT, Paine HA, Lloyd MD, Thompson AS, Threadgill MD. Woon EC, et al. Among authors: thompson as. Bioorg Med Chem. 2013 Sep 1;21(17):5218-27. doi: 10.1016/j.bmc.2013.06.031. Epub 2013 Jun 22. Bioorg Med Chem. 2013. PMID: 23849206

7

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro.

Paine HA, Nathubhai A, Woon EC, Sunderland PT, Wood PJ, Mahon MF, Lloyd MD, Thompson AS, Haikarainen T, Narwal M, Lehtiö L, Threadgill MD. Paine HA, et al. Among authors: thompson as. Bioorg Med Chem. 2015 Sep 1;23(17):5891-908. doi: 10.1016/j.bmc.2015.06.061. Epub 2015 Jul 2. Bioorg Med Chem. 2015. PMID: 26189030

8

Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)--a potential mechanism for the anti-cancer effects of ibuprofen.

Woodman TJ, Wood PJ, Thompson AS, Hutchings TJ, Steel GR, Jiao P, Threadgill MD, Lloyd MD. Woodman TJ, et al. Among authors: thompson as. Chem Commun (Camb). 2011 Jul 14;47(26):7332-4. doi: 10.1039/c1cc10763a. Epub 2011 May 26. Chem Commun (Camb). 2011. PMID: 21614403

9

Suzuki-Miyaura approach to JNJ-26076713, an orally active tetrahydroquinoline-containing alphaVbeta3/alphaVbeta5 integrin antagonist. enantioselective synthesis and stereochemical studies.

Kinney WA, Teleha CA, Thompson AS, Newport M, Hansen R, Ballentine S, Ghosh S, Mahan A, Grasa G, Zanotti-Gerosa A, Dingenen J, Schubert C, Zhou Y, Leo GC, McComsey DF, Santulli RJ, Maryanoff BE. Kinney WA, et al. Among authors: thompson as. J Org Chem. 2008 Mar 21;73(6):2302-10. doi: 10.1021/jo702551t. Epub 2008 Feb 16. J Org Chem. 2008. PMID: 18278942

10

N3-alkylation during formation of quinazolin-4-ones from condensation of anthranilamides and orthoamides.

Nathubhai A, Patterson R, Woodman TJ, Sharp HE, Chui MT, Chung HH, Lau SW, Zheng J, Lloyd MD, Thompson AS, Threadgill MD. Nathubhai A, et al. Among authors: thompson as. Org Biomol Chem. 2011 Sep 7;9(17):6089-99. doi: 10.1039/c1ob05430a. Epub 2011 Jul 13. Org Biomol Chem. 2011. PMID: 21750829

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