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The C8-2'-deoxyguanosine adduct of 2-amino-3-methylimidazo[1,2-d]naphthalene, a carbocyclic analogue of the potent mutagen 2-amino-3-methylimidazo[4,5-f]quinoline, is a block to replication in vitro.
Christov PP, Chowdhury G, Garmendia CA, Wang F, Stover JS, Elmquist CE, Kozekova A, Angel KC, Turesky RJ, Stone MP, Guengerich FP, Rizzo CJ. Christov PP, et al. Among authors: angel kc. Chem Res Toxicol. 2010 Jun 21;23(6):1076-88. doi: 10.1021/tx100053n. Chem Res Toxicol. 2010. PMID: 20377178 Free PMC article.
Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairing.
Eoff RL, Angel KC, Egli M, Guengerich FP. Eoff RL, et al. Among authors: angel kc. J Biol Chem. 2007 May 4;282(18):13573-84. doi: 10.1074/jbc.M700656200. Epub 2007 Mar 3. J Biol Chem. 2007. PMID: 17337730 Free article.
Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site.
Choi JY, Stover JS, Angel KC, Chowdhury G, Rizzo CJ, Guengerich FP. Choi JY, et al. Among authors: angel kc. J Biol Chem. 2006 Sep 1;281(35):25297-306. doi: 10.1074/jbc.M605699200. Epub 2006 Jul 10. J Biol Chem. 2006. PMID: 16835218 Free article.
DNA adduct bypass polymerization by Sulfolobus solfataricus DNA polymerase Dpo4: analysis and crystal structures of multiple base pair substitution and frameshift products with the adduct 1,N2-ethenoguanine.
Zang H, Goodenough AK, Choi JY, Irimia A, Loukachevitch LV, Kozekov ID, Angel KC, Rizzo CJ, Egli M, Guengerich FP. Zang H, et al. Among authors: angel kc. J Biol Chem. 2005 Aug 19;280(33):29750-64. doi: 10.1074/jbc.M504756200. Epub 2005 Jun 17. J Biol Chem. 2005. PMID: 15965231
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