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Page 1
Targeting lung heme iron by aerosol hemopexin adminstration in sickle cell disease pulmonary hypertension.
Lucero MJ, Lisk C, Cendali F, Swindle D, Setua S, Thangaraju K, Pak DI, O'Boyle Q, Lu S, Tolson R, Zaeske S, Rana N, Khan S, Westover N, DavizonCastillo P, George G, Hassell K, Nuss R, Brinkman N, Gentinetta T, Palmer AF, D'Alessandro A, Buehler PW, Irwin DC. Lucero MJ, et al. Among authors: d alessandro a. Free Radic Biol Med. 2025 Jan 23;229:458-473. doi: 10.1016/j.freeradbiomed.2025.01.045. Online ahead of print. Free Radic Biol Med. 2025. PMID: 39862998 Free article.
Herein, we evaluated in a murine model of hemolysis driven SCD-PH, if intrapulmonary Hpx administration bi-weekly for 10 weeks improves lung iron deposition, exercise tolerance, cardiovascular function, and multi-omic indices associated with SCD-PH. ...Hpx extravasates int …
Herein, we evaluated in a murine model of hemolysis driven SCD-PH, if intrapulmonary Hpx administration bi-weekly for 10 weeks improves lung …
Identification of candidate biomarkers and molecular networks associated with Pulmonary Arterial Hypertension using machine learning and plasma multi-Omics analysis.
Kheyfets VO, Sweatt AJ, Zhang H, Nemkov T, Heerdt P, Dzieciatkowska M, Stephenson D, LaCroix IS, D'Alessandro A, Oldham WM, Hansen K, Zamanian RT, Stenmark KR. Kheyfets VO, et al. Among authors: d alessandro a. medRxiv [Preprint]. 2024 Dec 20:2024.12.17.24319117. doi: 10.1101/2024.12.17.24319117. medRxiv. 2024. PMID: 39763543 Free PMC article. Preprint.
This model stratified patients into risk categories consistent with established markers of cardiac function, exercise tolerance, and the REVEAL 2.0 risk score. CONCLUSION: This study underscores the utility of integrated omics in unraveling PAH pathobiology in human subjec …
This model stratified patients into risk categories consistent with established markers of cardiac function, exercise tolerance, and …
Increased exercise tolerance in humanized G6PD-deficient mice.
Cendali FI, Lisk C, Dzieciatkowska M, LaCroix IS, Reisz JA, Harral J, Stephenson D, Hay AM, Wartchow EP, Darehshouri A, Dziewulska-Cronk KH, Buehler PW, Norris PJ, Deng X, Busch MP, Earley EJ, Page GP, Hansen KC, Zimring JC, Irwin DC, Nemkov T, D'Alessandro A. Cendali FI, et al. Among authors: d alessandro a. Blood Adv. 2025 Jan 28;9(2):321-334. doi: 10.1182/bloodadvances.2024013968. Blood Adv. 2025. PMID: 39514761 Free PMC article.
Despite the systemic generation of reactive oxygen species during exercise, the effects of exercise on individuals with G6PD deficiency remain poorly understood This study used humanized mouse models expressing the G6PD Mediterranean variant (S188F, with 10% enzymat …
Despite the systemic generation of reactive oxygen species during exercise, the effects of exercise on individuals with G6PD d …
A Multiomics Assessment of Preoperative Exercise in Pancreatic Cancer Survivors Receiving Neoadjuvant Therapy: A Case Series.
Nemkov T, Cendali F, Dzieciatkowska M, Stephenson D, Hansen KC, Jankowski CM, D'Alessandro A, Marker RJ. Nemkov T, et al. Among authors: d alessandro a. Pathophysiology. 2024 Mar 20;31(1):166-182. doi: 10.3390/pathophysiology31010013. Pathophysiology. 2024. PMID: 38535623 Free PMC article.
To molecularly characterize the impact of exercise on mitigating neoadjuvant treatment (NAT)-induced physical decline in pancreatic ductal adenocarcinoma (PDAC) patients, a multi-omics approach was employed for the analysis of plasma samples before and after a personalized …
To molecularly characterize the impact of exercise on mitigating neoadjuvant treatment (NAT)-induced physical decline in pancreatic d …
The plasma metabolome is associated with preservation of physiological function following lifelong aerobic exercise in mice.
Murray KO, Maurer GS, Gioscia-Ryan RA, Zigler MC, Ludwig KR, D'Alessandro A, Reisz JA, Rossman MJ, Seals DR, Clayton ZS. Murray KO, et al. Among authors: d alessandro a. Geroscience. 2024 Jun;46(3):3311-3324. doi: 10.1007/s11357-024-01062-x. Epub 2024 Jan 24. Geroscience. 2024. PMID: 38265578 Free PMC article.
Declines in physiological function with aging are strongly linked to age-related diseases. Lifelong voluntary aerobic exercise (LVAE) preserves physiological function with aging, possibly by increasing cellular quality control processes, but the circulating molecular trans …
Declines in physiological function with aging are strongly linked to age-related diseases. Lifelong voluntary aerobic exercise (LVAE) …
Time-Efficient, High-Resistance Inspiratory Muscle Strength Training Increases Exercise Tolerance in Midlife and Older Adults.
Craighead DH, Freeberg KA, Heinbockel TC, Rossman MJ, Jackman RA, McCarty NP, Jankowski LR, Nemkov T, Reisz JA, D'Alessandro A, Chonchol M, Bailey EF, Seals DR. Craighead DH, et al. Among authors: d alessandro a. Med Sci Sports Exerc. 2024 Feb 1;56(2):266-276. doi: 10.1249/MSS.0000000000003291. Epub 2023 Sep 12. Med Sci Sports Exerc. 2024. PMID: 37707508 Free PMC article. Clinical Trial.
Cardiorespiratory fitness (VO 2peak ) was unchanged, but exercise tolerance, measured as treadmill exercise time during a graded exercise treadmill test, increased with IMST (baseline, 539 42 s; end intervention, 606 42 s; P = 0.01) but not sham training (bas …
Cardiorespiratory fitness (VO 2peak ) was unchanged, but exercise tolerance, measured as treadmill exercise time during a grad …
Metabolic Signatures of Performance in Elite World Tour Professional Male Cyclists.
Nemkov T, Cendali F, Stefanoni D, Martinez JL, Hansen KC, San-Millán I, D'Alessandro A. Nemkov T, et al. Among authors: d alessandro a. Sports Med. 2023 Aug;53(8):1651-1665. doi: 10.1007/s40279-023-01846-9. Epub 2023 May 6. Sports Med. 2023. PMID: 37148487 Free PMC article.
The goal of this study was to define molecular signatures of exertion under controlled exercise conditions and use these signatures as a framework for assessing cycling performance in a World Tour competition. ...Blood profiles of lactate, carboxylic acids, fatty acids, an …
The goal of this study was to define molecular signatures of exertion under controlled exercise conditions and use these signatures a …
Metabolic correlates to critical speed in murine models of sickle cell disease.
Cendali FI, Nemkov T, Lisk C, Lacroix IS, Nouraie SM, Zhang Y, Gordeuk VR, Buehler PW, Irwin D, D'Alessandro A. Cendali FI, et al. Among authors: d alessandro a. Front Physiol. 2023 Mar 13;14:1151268. doi: 10.3389/fphys.2023.1151268. eCollection 2023. Front Physiol. 2023. PMID: 37007990 Free PMC article.
Introduction: Exercise intolerance is a common clinical manifestation in patients with sickle cell disease (SCD), though the mechanisms are incompletely understood. ...Discussion: We identified novel circulating metabolic markers of exercise intolerance in mouse mod …
Introduction: Exercise intolerance is a common clinical manifestation in patients with sickle cell disease (SCD), though the mechanis …
Dried blood spot characterization of sex-based metabolic responses to acute running exercise.
Cendali F, D'Alessandro A, Nemkov T. Cendali F, et al. Among authors: d alessandro a. Anal Sci Adv. 2023 Feb 5;4(1-2):37-48. doi: 10.1002/ansa.202200039. eCollection 2023 Feb. Anal Sci Adv. 2023. PMID: 38715582 Free PMC article.
To demonstrate the utility of advanced dried microsampling to characterize metabolomic and lipidomic changes during exercise, we obtained samples before and after a 2-mile run from twelve (8 male, 4 female) healthy volunteers with various ranges in activity levels. ...The …
To demonstrate the utility of advanced dried microsampling to characterize metabolomic and lipidomic changes during exercise, we obta …
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