Targeting lung heme iron by aerosol hemopexin adminstration in sickle cell disease pulmonary hypertension.
Lucero MJ, Lisk C, Cendali F, Swindle D, Setua S, Thangaraju K, Pak DI, O'Boyle Q, Lu S, Tolson R, Zaeske S, Rana N, Khan S, Westover N, DavizonCastillo P, George G, Hassell K, Nuss R, Brinkman N, Gentinetta T, Palmer AF, D'Alessandro A, Buehler PW, Irwin DC.
Lucero MJ, et al. Among authors: d alessandro a.
Free Radic Biol Med. 2025 Jan 23;229:458-473. doi: 10.1016/j.freeradbiomed.2025.01.045. Online ahead of print.
Free Radic Biol Med. 2025.
PMID: 39862998
Free article.
Herein, we evaluated in a murine model of hemolysis driven SCD-PH, if intrapulmonary Hpx administration bi-weekly for 10 weeks improves lung iron deposition, exercise tolerance, cardiovascular function, and multi-omic indices associated with SCD-PH. ...Hpx extravasates int …
Herein, we evaluated in a murine model of hemolysis driven SCD-PH, if intrapulmonary Hpx administration bi-weekly for 10 weeks improves lung …