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Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome.
Stener-Victorin E, Padmanabhan V, Walters KA, Campbell RE, Benrick A, Giacobini P, Dumesic DA, Abbott DH. Stener-Victorin E, et al. Endocr Rev. 2020 Jul 1;41(4):bnaa010. doi: 10.1210/endrev/bnaa010. Endocr Rev. 2020. PMID: 32310267 Free PMC article. Review.
More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome (PCOS), the leading cause of female reproductive and metabolic dysfunction. ...In this review, we detail which animal models are more suitable for contributing to …
More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome (PCOS), the leading cause of female …
Evidence from animal models on the pathogenesis of PCOS.
Walters KA, Bertoldo MJ, Handelsman DJ. Walters KA, et al. Best Pract Res Clin Endocrinol Metab. 2018 Jun;32(3):271-281. doi: 10.1016/j.beem.2018.03.008. Epub 2018 Mar 31. Best Pract Res Clin Endocrinol Metab. 2018. PMID: 29779581 Review.
Polycystic ovarian syndrome (PCOS) is the most common endocrine condition in women, and is characterized by reproductive, endocrine and metabolic features. ...Decisive studies are required to unravel the origins of PCOS, but due to ethical and logistical reasons the
Polycystic ovarian syndrome (PCOS) is the most common endocrine condition in women, and is characterized by reproductive, endo
Gestational Diabetes Mellitus: A Harbinger of the Vicious Cycle of Diabetes.
Alejandro EU, Mamerto TP, Chung G, Villavieja A, Gaus NL, Morgan E, Pineda-Cortel MRB. Alejandro EU, et al. Int J Mol Sci. 2020 Jul 15;21(14):5003. doi: 10.3390/ijms21145003. Int J Mol Sci. 2020. PMID: 32679915 Free PMC article. Review.
In addition to the current challenges in the management and diagnosis of and the complications associated with GDM, we discuss current preclinical models of GDM to better understand the underlying pathophysiology of the disease and the timely need to increase …
In addition to the current challenges in the management and diagnosis of and the complications associated with GDM, we discuss current precl …
Update on Animal Models of Polycystic Ovary Syndrome.
Stener-Victorin E. Stener-Victorin E. Endocrinology. 2022 Oct 23;163(12):bqac164. doi: 10.1210/endocr/bqac164. Endocrinology. 2022. PMID: 36201611 Free PMC article.
Polycystic ovary syndrome (PCOS) is a complex disease affecting up to 15% of women of reproductive age. ...Despite the high prevalence of PCOS, its etiology remains unclear. To understand the pathophysiology of PCOS, how it is inherited,
Polycystic ovary syndrome (PCOS) is a complex disease affecting up to 15% of women of reproductive age. ...Despite the
Animal models of the polycystic ovary syndrome phenotype.
Padmanabhan V, Veiga-Lopez A. Padmanabhan V, et al. Steroids. 2013 Aug;78(8):734-40. doi: 10.1016/j.steroids.2013.05.004. Epub 2013 May 20. Steroids. 2013. PMID: 23701728 Free PMC article. Review.
The etiology of the polycystic ovary syndrome (PCOS) remains unclear, despite its high prevalence among infertility disorders in women of reproductive age. Although there is evidence for a genetic component of the disorder, other causes, such as prenat …
The etiology of the polycystic ovary syndrome (PCOS) remains unclear, despite its high prevalence among infertil …
Mitochondrial dysfunction: An emerging link in the pathophysiology of polycystic ovary syndrome.
Shukla P, Mukherjee S. Shukla P, et al. Mitochondrion. 2020 May;52:24-39. doi: 10.1016/j.mito.2020.02.006. Epub 2020 Feb 17. Mitochondrion. 2020. PMID: 32081727 Review.
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by irregular menstrual cycles, hyperandrogenism and subfertility. ...Furthermore, contrasting remarks against involvement of mitochondrial dysfunction in PCOS pathophysiology
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by irregular menstrual cycles, hyperandro
Dehydroepiandrosterone to induce murine models for the study of polycystic ovary syndrome.
Motta AB. Motta AB. J Steroid Biochem Mol Biol. 2010 Apr;119(3-5):105-11. doi: 10.1016/j.jsbmb.2010.02.015. Epub 2010 Feb 25. J Steroid Biochem Mol Biol. 2010. PMID: 20188831 Review.
During the last decade a battery of animal models used for the study of polycystic ovary syndrome (PCOS) have allowed a focus on different aspects of the pathology. ...Although insulin-sensitizing agents, such as biguanides, are clinically used …
During the last decade a battery of animal models used for the study of polycystic ovary syndrome (PCOS) …
Experimental models of polycystic ovary syndrome: An update.
Divyashree S, Janhavi P, Ravindra PV, Muthukumar SP. Divyashree S, et al. Life Sci. 2019 Nov 15;237:116911. doi: 10.1016/j.lfs.2019.116911. Epub 2019 Oct 10. Life Sci. 2019. PMID: 31606385 Review.
Polycystic ovary syndrome (PCOS) is one of the major endocrine disorders in women. ...Animal models of PCOS aids in studying various facts beginning from etiology to the treatment, hence, several animal models have been deve
Polycystic ovary syndrome (PCOS) is one of the major endocrine disorders in women. ...Animal models of PC
Effect of maternal PCOS and PCOS-like phenotype on the offspring's health.
Puttabyatappa M, Cardoso RC, Padmanabhan V. Puttabyatappa M, et al. Mol Cell Endocrinol. 2016 Nov 5;435:29-39. doi: 10.1016/j.mce.2015.11.030. Epub 2015 Nov 27. Mol Cell Endocrinol. 2016. PMID: 26639019 Free PMC article. Review.
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder with both reproductive and metabolic abnormalities affecting women of reproductive age. ...Because women with PCOS manifest hyperandrogenism during pregnancy, changes in the gestational en
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder with both reproductive and metabolic abnormaliti
Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS).
Siemienowicz KJ, Coukan F, Franks S, Rae MT, Duncan WC. Siemienowicz KJ, et al. Mol Cell Endocrinol. 2021 Jan 1;519:111042. doi: 10.1016/j.mce.2020.111042. Epub 2020 Oct 1. Mol Cell Endocrinol. 2021. PMID: 33010309
Polycystic ovary syndrome (PCOS) affects over 10% of women. Insulin resistance, elevated free fatty acids (FFAs) and increased adiposity are key factors contributing to metabolic dysfunction in PCOS. ...In adulthood, PA sheep developed adipocyte hypertrophy i
Polycystic ovary syndrome (PCOS) affects over 10% of women. Insulin resistance, elevated free fatty acids (FFAs) and in
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