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2,331 results

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Page 1
Anisomycin and the reconsolidation hypothesis.
Rudy JW, Biedenkapp JC, Moineau J, Bolding K. Rudy JW, et al. Learn Mem. 2006 Jan-Feb;13(1):1-3. doi: 10.1101/lm.157806. Learn Mem. 2006. PMID: 16452648 Review. No abstract available.
Anisomycin alleviates cognitive impairments and pathological features in 3xTg-AD mice.
Jiao JJ, Hu Y, Cui YJ, Tuo CM, Wang YX, Li XY, Zhang Y, Wu MN. Jiao JJ, et al. Neuropharmacology. 2024 Dec 15;261:110159. doi: 10.1016/j.neuropharm.2024.110159. Epub 2024 Sep 18. Neuropharmacology. 2024. PMID: 39303856
However, it is not clear whether anisomycin can exert neuroprotective effect in AD. In the present study, anisomycin was intragastrically administrated to female triple-transgenic AD (3xTg-AD) model mice, then Morris water maze test was used to observe the long-term …
However, it is not clear whether anisomycin can exert neuroprotective effect in AD. In the present study, anisomycin was intra …
Anisomycin inhibits Coxsackievirus B replication by promoting the lysosomal degradation of eEF1A1.
Shao E, Zhao S, Dong Y, Wang Y, Fei Y, Li S, Wang L, Bashir T, Luan T, Lin L, Wang Y, Zhao W, Zhong Z. Shao E, et al. Antiviral Res. 2023 Jul;215:105621. doi: 10.1016/j.antiviral.2023.105621. Epub 2023 May 6. Antiviral Res. 2023. PMID: 37156267
However, it is unknown if anisomycin can act as an antiviral against CVB infection. Here we observed that anisomycin showed potent inhibition on CVB type 3 (CVB3) infection with negligible cytotoxicity when applied at the early stage of virus infection. ...Similar t …
However, it is unknown if anisomycin can act as an antiviral against CVB infection. Here we observed that anisomycin showed po …
Cordycepin buffers anisomycin-induced fear memory deficit by restoring hippocampal BDNF.
Li M, Wang L, Guo S, Huang N, Ai H. Li M, et al. Biochem Biophys Res Commun. 2023 Jul 12;665:118-123. doi: 10.1016/j.bbrc.2023.05.011. Epub 2023 May 3. Biochem Biophys Res Commun. 2023. PMID: 37156049
The process of memory consolidation involves the synthesis of new proteins, and interfering with protein synthesis through anisomycin can impair memory. Memory deficits due to aging and sleep disorders may also result from a reduction in protein synthesis. ...Our findings …
The process of memory consolidation involves the synthesis of new proteins, and interfering with protein synthesis through anisomycin …
Anisomycin inhibits angiogenesis, growth, and survival of triple-negative breast cancer through mitochondrial dysfunction, AMPK activation, and mTOR inhibition.
Yang W, Zhou C, Sun Q, Guan G. Yang W, et al. Can J Physiol Pharmacol. 2022 Jul 1;100(7):612-620. doi: 10.1139/cjpp-2021-0577. Epub 2022 Jul 19. Can J Physiol Pharmacol. 2022. PMID: 35852219
In our work, we showed that inhibition of mitochondrial function by anisomycin is effective against triple-negative breast cancer (TNBC). Anisomycin inhibits growth and induces caspase-dependent apoptosis in a panel of TNBC cell lines. ...Mechanistic studies show th …
In our work, we showed that inhibition of mitochondrial function by anisomycin is effective against triple-negative breast cancer (TN …
Anisomycin inhibits the activity of human ovarian cancer stem cells via regulating antisense RNA NCBP2-AS2/MEK/ERK/STAT3 signaling.
Ling L, Wen Y, Xiong Y, Liu X, Chen J, Liu T, Zhang B. Ling L, et al. J Gene Med. 2024 Jan;26(1):e3571. doi: 10.1002/jgm.3571. Epub 2023 Jul 22. J Gene Med. 2024. PMID: 37483091
BACKGROUND: Ovarian cancer stem cells (OCSCs) are the main cause of relapse and drug resistance in patients with ovarian cancer. Anisomycin has been shown to be an effective antitumor agent, but its mechanism of action in ovarian cancer remains elusive. METHODS: CD44+/CD13 …
BACKGROUND: Ovarian cancer stem cells (OCSCs) are the main cause of relapse and drug resistance in patients with ovarian cancer. Anisomyc …
Anisomycin Induces Senescence and Death of Ovarian Cancer Stem Cells Through the MicroRNA-340/SENP6/SUMOylation Pathway.
Yang L, Xia Y, Cui Z, Lai Y, Huang Y, Xiong Y, Chen J, Liu T. Yang L, et al. J Gene Med. 2026 Jan;28(1):e70081. doi: 10.1002/jgm.70081. J Gene Med. 2026. PMID: 41494663
Transcriptomic, biochemical, and molecular assays were performed to identify downstream pathways. Anisomycin treatment markedly inhibited proliferation and promoted senescence and cell death of OCSCs. Mechanistically, anisomycin induced upregulation of microRNA-340, …
Transcriptomic, biochemical, and molecular assays were performed to identify downstream pathways. Anisomycin treatment markedly inhib …
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval.
Nader K, Schafe GE, Le Doux JE. Nader K, et al. Nature. 2000 Aug 17;406(6797):722-6. doi: 10.1038/35021052. Nature. 2000. PMID: 10963596
Infusion of the protein synthesis inhibitor anisomycin into the LBA shortly after training prevents consolidation of fear memories. Here we show that consolidated fear memories, when reactivated during retrieval, return to a labile state in which infusion of anisomycin …
Infusion of the protein synthesis inhibitor anisomycin into the LBA shortly after training prevents consolidation of fear memories. H …
Anisomycin is active in preclinical models of pediatric acute myeloid leukemia via specifically inhibiting mitochondrial respiration.
Zhang C, Deng Q, Bao S, Zhu J. Zhang C, et al. J Bioenerg Biomembr. 2021 Dec;53(6):693-701. doi: 10.1007/s10863-021-09918-z. Epub 2021 Sep 1. J Bioenerg Biomembr. 2021. PMID: 34468904
In addition, FLT3-ITD cells were more sensitive to anisomycin than FLT3 WT cells. Mechanistic studies revealed that anisomycin acted on AML in a p38-independent manner. ...AML rho(0) cells that lack of mitochondrial respiration exhibited resistance to anisomycin …
In addition, FLT3-ITD cells were more sensitive to anisomycin than FLT3 WT cells. Mechanistic studies revealed that anisomycin …
Anisomycin induces hair cell death and blocks supporting cell proliferation in zebrafish lateral line neuromast.
Yuan X, Qin Y, Wang J, Fan C. Yuan X, et al. Comp Biochem Physiol C Toxicol Pharmacol. 2021 Sep;247:109053. doi: 10.1016/j.cbpc.2021.109053. Epub 2021 Apr 19. Comp Biochem Physiol C Toxicol Pharmacol. 2021. PMID: 33887477
However, the ototoxicity of anisomycin has not been examined. In this study, the ototoxicity of anisomycin was evaluated using zebrafish lateral line. ...This study provides primary ototoxicity evaluation for anisomycin....
However, the ototoxicity of anisomycin has not been examined. In this study, the ototoxicity of anisomycin was evaluated using …
2,331 results