Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
2001 1
2004 1
2005 1
2007 1
2012 1
2013 2
2014 1
2015 1
2016 2
2017 2
2018 3
2019 3
2020 3
2021 2
2023 4
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

28 results

Results by year

Filters applied: . Clear all
Page 1
Safety and efficacy of Bixa orellana (achiote, annatto) leaf extracts.
Stohs SJ. Stohs SJ. Phytother Res. 2014 Jul;28(7):956-60. doi: 10.1002/ptr.5088. Epub 2013 Dec 4. Phytother Res. 2014. PMID: 24357022 Review.
Many more studies have been conducted and published involving Bixa seed (annatto) extracts than with leaf extracts. No subchronic safety (toxicity) studies have been conducted in animals. ...Bixa leaf extracts appear to be safe when given under current conditions of …
Many more studies have been conducted and published involving Bixa seed (annatto) extracts than with leaf extracts. No subchronic …
Safety of annatto E and the exposure to the annatto colouring principles bixin and norbixin (E 160b) when used as a food additive.
EFSA Panel on Food Additives and Flavourings (EFSA FAF Panel); Younes M, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gürtler R, Gundert-Remy U, Husøy T, Mennes W, Moldeus P, Oskarsson A, Shah R, Waalkens-Berendsen I, Wölfle D, Crebelli R, Leblanc JC, Tard A, Aquilina G. EFSA Panel on Food Additives and Flavourings (EFSA FAF Panel), et al. EFSA J. 2019 Mar 13;17(3):e05626. doi: 10.2903/j.efsa.2019.5626. eCollection 2019 Mar. EFSA J. 2019. PMID: 32626252 Free PMC article.
The Scientific Panel on Food Additives and Flavouring (FAF) provides a scientific opinion on the safety evaluation of annatto E and an exposure assessment of the annatto colouring principles bixin and norbixin (E 160b) when used as a food additive, taking int …
The Scientific Panel on Food Additives and Flavouring (FAF) provides a scientific opinion on the safety evaluation of annatto
A toxicological evaluation of geranylgeraniol.
Preece K, Glávits R, Foster JR, Murbach T, Endres JR, Hirka G, Vértesi A, Béres E, Szakonyiné IP. Preece K, et al. Regul Toxicol Pharmacol. 2021 Aug;124:104975. doi: 10.1016/j.yrtph.2021.104975. Epub 2021 Jun 16. Regul Toxicol Pharmacol. 2021. PMID: 34144118
Geranylgeraniol (GGOH) is an isoprenoid compound found in annatto seeds and an intermediate of the mevalonate pathway found within organisms serving various functions. Toxicological studies on its safety profile are not readily available. To assess the safety
Geranylgeraniol (GGOH) is an isoprenoid compound found in annatto seeds and an intermediate of the mevalonate pathway found within or …
Bixin-loaded colloidal nanodelivery systems, techniques and applications.
Enayati A, Rezaei A, Falsafi SR, Rostamabadi H, Malekjani N, Akhavan-Mahdavi S, Kharazmi MS, Jafari SM. Enayati A, et al. Food Chem. 2023 Jun 30;412:135479. doi: 10.1016/j.foodchem.2023.135479. Epub 2023 Jan 16. Food Chem. 2023. PMID: 36709686 Review.
Bixin is the cis-carotenoid from the seed of achiote tree or annatto. It is an approved liposoluble apocarotenoid by FDA as colorant and additive in the food industry. ...Moreover, it provides a comprehensive review of bioavailability, physicochemical properties, and appli …
Bixin is the cis-carotenoid from the seed of achiote tree or annatto. It is an approved liposoluble apocarotenoid by FDA as colorant …
A 12-week evaluation of annatto tocotrienol supplementation for postmenopausal women: safety, quality of life, body composition, physical activity, and nutrient intake.
Shen CL, Wang S, Yang S, Tomison MD, Abbasi M, Hao L, Scott S, Khan MS, Romero AW, Felton CK, Mo H. Shen CL, et al. BMC Complement Altern Med. 2018 Jun 28;18(1):198. doi: 10.1186/s12906-018-2263-0. BMC Complement Altern Med. 2018. PMID: 29954374 Free PMC article. Clinical Trial.
BACKGROUND: Evidence suggests that tocotrienols may benefit bone health in osteopenic women. However, their safety in this population has never been investigated. This study was to evaluate the safety of a 12-week supplementation of annato tocotrienol in postmenopau …
BACKGROUND: Evidence suggests that tocotrienols may benefit bone health in osteopenic women. However, their safety in this population …
Safety and efficacy of cis-norbixin di-potassium salt (annatto F) for cats and dogs.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP); Rychen G, Azimonti G, Bampidis V, de Lourdes Bastos M, Bories G, Chesson A, Cocconcelli PS, Flachowsky G, Gropp J, Kolar B, Kouba M, López Puente S, López-Alonso M, Mantovani A, Mayo B, Ramos F, Saarela M, Villa RE, Wallace RJ, Wester P, Costa LG, Lundebye AK, Renshaw D, Holczknecht O, Vettori MV, Aquilina G. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), et al. EFSA J. 2017 Apr 26;15(4):e04764. doi: 10.2903/j.efsa.2017.4764. eCollection 2017 Apr. EFSA J. 2017. PMID: 32625466 Free PMC article.
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of annatto F (alkali-processed norbixin, acid-precipitated) for cats …
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked t …
Comprehensive Update on Carotenoid Colorants from Plants and Microalgae: Challenges and Advances from Research Laboratories to Industry.
Rodriguez-Amaya DB, Esquivel P, Meléndez-Martínez AJ. Rodriguez-Amaya DB, et al. Foods. 2023 Nov 10;12(22):4080. doi: 10.3390/foods12224080. Foods. 2023. PMID: 38002140 Free PMC article. Review.
The current list of natural carotenoid colorants consists of plant-derived annatto (bixin and norbixin), paprika (capsanthin and capsorubin), saffron (crocin), tomato and gac fruit lycopene, marigold lutein, and red palm oil (alpha- and beta-carotene), along with microalga …
The current list of natural carotenoid colorants consists of plant-derived annatto (bixin and norbixin), paprika (capsanthin and caps …
Therapeutic potential of bixin on inflammation: a mini review.
Shadisvaaran S, Chin KY, Mohd-Said S, Leong XF. Shadisvaaran S, et al. Front Nutr. 2023 Sep 13;10:1209248. doi: 10.3389/fnut.2023.1209248. eCollection 2023. Front Nutr. 2023. PMID: 37781110 Free PMC article. Review.
More well-planned clinical studies should be performed to verify its effectiveness and safety profile....
More well-planned clinical studies should be performed to verify its effectiveness and safety profile....
Exposure assessment of annatto colouring principles bixin and norbixin (E 160b) when used as food additives.
European Food Safety Authority (EFSA); Tard A. European Food Safety Authority (EFSA), et al. EFSA J. 2017 Aug 10;15(8):e04966. doi: 10.2903/j.efsa.2.17.4966. eCollection 2017 Aug. EFSA J. 2017. PMID: 32625627 Free PMC article.
In 2016, the EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) adopted a scientific opinion on the safety of annatto extracts (E 160b) as a food additive. In that opinion, the Panel concluded that the toxicological database was sufficient to deri …
In 2016, the EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) adopted a scientific opinion on the safety of a
Molecular Mechanisms of Action of Tocotrienols in Cancer: Recent Trends and Advancements.
Aggarwal V, Kashyap D, Sak K, Tuli HS, Jain A, Chaudhary A, Garg VK, Sethi G, Yerer MB. Aggarwal V, et al. Int J Mol Sci. 2019 Feb 2;20(3):656. doi: 10.3390/ijms20030656. Int J Mol Sci. 2019. PMID: 30717416 Free PMC article. Review.
Tocotrienols, found in several natural sources such as rice bran, annatto seeds, and palm oil have been reported to exert various beneficial health promoting properties especially against chronic diseases, including cancer. ...Tocotrienols can suppress the growth of differ …
Tocotrienols, found in several natural sources such as rice bran, annatto seeds, and palm oil have been reported to exert various ben …
28 results