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Year Number of Results
1801 2
1802 1
1848 2
1849 1
1850 1
1853 1
1854 1
1857 1
1868 1
1872 2
1873 2
1874 1
1875 2
1876 1
1877 2
1878 1
1879 3
1880 2
1881 5
1882 4
1883 1
1884 3
1885 1
1886 1
1887 4
1888 4
1889 2
1890 1
1892 4
1893 6
1894 2
1895 9
1896 14
1897 10
1898 15
1899 8
1900 9
1901 5
1902 6
1904 8
1905 8
1906 7
1907 10
1908 6
1909 23
1910 9
1911 13
1912 10
1913 9
1914 12
1915 14
1916 5
1917 11
1918 15
1919 12
1920 14
1921 8
1922 3
1923 8
1924 15
1925 20
1926 17
1927 10
1928 17
1929 17
1930 17
1931 11
1932 12
1933 12
1934 9
1935 16
1936 20
1937 16
1938 27
1939 17
1940 19
1941 18
1942 19
1943 9
1944 18
1945 154
1946 497
1947 613
1948 717
1949 621
1950 1387
1951 1779
1952 2113
1953 2277
1954 2159
1955 2451
1956 2355
1957 2574
1958 2584
1959 2334
1960 2131
1961 2281
1962 2397
1963 3513
1964 4258
1965 3342
1966 2818
1967 3205
1968 3859
1969 4214
1970 4322
1971 4623
1972 4429
1973 4740
1974 5087
1975 6219
1976 6476
1977 6550
1978 6610
1979 7387
1980 7560
1981 8464
1982 9399
1983 10881
1984 11670
1985 12273
1986 12875
1987 13333
1988 13889
1989 15885
1990 16428
1991 17070
1992 17375
1993 18255
1994 18531
1995 21650
1996 24545
1997 25921
1998 28108
1999 29082
2000 30705
2001 31776
2002 32827
2003 34687
2004 36444
2005 40356
2006 43454
2007 45656
2008 47626
2009 51021
2010 55400
2011 60403
2012 64833
2013 68815
2014 72026
2015 75769
2016 77531
2017 80811
2018 85006
2019 90495
2020 102173
2021 109611
2022 111187
2023 105239
2024 103895
2025 1628

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1,926,900 results

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Page 1
Design, synthesis and biological evaluation of new SIRT3 activators for the treatment of triple-negative breast cancer.
Huang G, Wang H, Zhao X, Wang C, Zhang J, Yao D, Li C. Huang G, et al. Bioorg Med Chem. 2024 Dec 10;118:118040. doi: 10.1016/j.bmc.2024.118040. Online ahead of print. Bioorg Med Chem. 2024. PMID: 39671732
In this study, we designed and synthesized a series of 1,4-DHP derivatives by structure-based strategy, 43 was documented to be a potent SIRT3 activator and exhibited profound anti-proliferative activity in BT-549 and MDA-MB-231 cells with low toxicity over normal cells. . …
In this study, we designed and synthesized a series of 1,4-DHP derivatives by structure-based strategy, 43 was documented to be a potent SIR …
Anti-inflammatory and cytoprotective polypharmacology of Canephron N reveals targeting of the IKK-NF-kappaB and p38-MK2-RIPK1 axes.
Milosevic M, Magnutzki A, Braun T, Hussain S, Jakschitz T, Kragl M, Soeberdt M, Nausch B, Bonn GK, Huber LA, Valovka T. Milosevic M, et al. Biomed Pharmacother. 2024 Dec 12;182:117747. doi: 10.1016/j.biopha.2024.117747. Online ahead of print. Biomed Pharmacother. 2024. PMID: 39671726
Canephron N is an orally bioavailable herbal medicine with anti-inflammatory, spasmolytic, anti-adhesive, and anti-nociceptive therapeutic effects that is approved for the treatment of uncomplicated urinary tract infections. Here, we used renal tubular epithe …
Canephron N is an orally bioavailable herbal medicine with anti-inflammatory, spasmolytic, anti-adhesive, and anti-noci …
Polymethoxyflavones from Gardenia oudiepe and semi-synthetic derivatives reduce nociception in mice: Evidence for the involvement of the MAPK pathway.
Daviaud C, Ferraz CAA, E Silva MG, de Alencar Filho EB, Evangelista Mendes de Lima SY, Dumontet V, Júnior LJQ, da Silva Almeida JRG, Picot L, Baranger K, de Oliveira Júnior RG, Grougnet R. Daviaud C, et al. Biomed Pharmacother. 2024 Dec 12;182:117742. doi: 10.1016/j.biopha.2024.117742. Online ahead of print. Biomed Pharmacother. 2024. PMID: 39671724
Biochemical assays on RAW264.7 cells elucidated anti-inflammatory properties, highlighting PAFs 7 and 8 as the most active. The study indicates a peripheral anti-nociceptive profile, suggesting interferences with the production of inflammatory mediators implicated i …
Biochemical assays on RAW264.7 cells elucidated anti-inflammatory properties, highlighting PAFs 7 and 8 as the most active. The study …
Antiviral-effect of nitrogen-containing compounds isolated from Sarcodon imbricatus on influenza A virus through regulation of ZBP-1 mediated necroptosis.
Yang HJ, Kwon EB, Kim YS, Choi JG, Li W, Na M. Yang HJ, et al. Biomed Pharmacother. 2024 Dec 12;182:117732. doi: 10.1016/j.biopha.2024.117732. Online ahead of print. Biomed Pharmacother. 2024. PMID: 39671721
Particularly, Compound 2 exhibited significant antiviral activity in post-treatment assays, reducing viral protein expression and inhibiting viral replication with an IC(50) of 14.9 mumol/L. Additionally, it demonstrated anti-inflammatory effects by reducing levels of cyto …
Particularly, Compound 2 exhibited significant antiviral activity in post-treatment assays, reducing viral protein expression and inhibiting …
In-situ Sprayed platelet-derived small extracellular vesicles for the skin flap survival by reducing PANoptosis.
Liu Z, Chen DH, Lin ZH, Wang ZY, Peng H, Liu RT, Hu ZC, He YH, Wei XJ, Zhang CQ, Feng Y, Tang Q, Zhu ZZ. Liu Z, et al. Biomaterials. 2024 Dec 5;316:123001. doi: 10.1016/j.biomaterials.2024.123001. Online ahead of print. Biomaterials. 2024. PMID: 39671720
Mechanistic analysis through RNA sequencing indicated that the protective effects of PL-sEV against PANoptosis likely resulted from its anti-inflammatory properties, particularly via suppression of the NF-kappaB signaling pathway. ...
Mechanistic analysis through RNA sequencing indicated that the protective effects of PL-sEV against PANoptosis likely resulted from its a …
Integrated application of target-based and ligand-based drug-designing approaches for the identification of novel caspase-6 inhibitors.
Chatterjee C, Ghosh P, Singh R, Kumar A, Singh SK. Chatterjee C, et al. J Biomol Struct Dyn. 2024 Dec 13:1-15. doi: 10.1080/07391102.2024.2440149. Online ahead of print. J Biomol Struct Dyn. 2024. PMID: 39671711
Thus, ZINC000069415222 was identified as a potential CASP6 inhibitor that could be further explored experimentally as an anti-AD drug....
Thus, ZINC000069415222 was identified as a potential CASP6 inhibitor that could be further explored experimentally as an anti-AD drug …
Experimental retrieval of metaholographic images via evanescent wave using a single-layer nanostructure for encryption.
Xie Y, Huang T, Huang Z, Zeng Y, Li Z, Zheng G. Xie Y, et al. Opt Lett. 2024 Dec 15;49(24):7056-7059. doi: 10.1364/OL.542690. Opt Lett. 2024. PMID: 39671639
Metasurfaces have demonstrated significant potential in optical encryption and anti-counterfeiting due to their incredible capability of manipulating various light properties. ...
Metasurfaces have demonstrated significant potential in optical encryption and anti-counterfeiting due to their incredible capability …
Efficient generation of multi-order Raman radiation in aqueous solutions derived from -CH2 and -NH2 vibrations via cascaded four-wave mixing and Stokes processes.
Dou Z, Wang J, Liu H, Wei G, Zhao Y, Xiu J, Xiao F, Men Z. Dou Z, et al. Opt Lett. 2024 Dec 15;49(24):7044-7047. doi: 10.1364/OL.547191. Opt Lett. 2024. PMID: 39671636
By varying the 3AP concentration and pump energy, these two peaks from 3AP act as new pump sources, enabling the successful generation of up to 16th-order Stokes and 5th-order anti-Stokes radiation through C-FWM and C-Stokes processes. The resulting spectrum spans a broad …
By varying the 3AP concentration and pump energy, these two peaks from 3AP act as new pump sources, enabling the successful generation of up …
Watt-scale near-diffraction-limited mid-infrared laser delivery by a chalcogenide anti-resonant fiber.
Wang XG, Liang X, Jiao K, Bai S, Wang X, Wang R. Wang XG, et al. Opt Lett. 2024 Dec 15;49(24):6960-6963. doi: 10.1364/OL.541805. Opt Lett. 2024. PMID: 39671614
We have developed an effective one-step extrusion method to prepare a nodeless chalcogenide hollow-core anti-resonance fiber, characterized by excellent symmetry and less requirements for drawing pressure in achieving the desired wall thickness. ...
We have developed an effective one-step extrusion method to prepare a nodeless chalcogenide hollow-core anti-resonance fiber, charact …
Observing high dependence of red luminescence on localized symmetry in Mn4+ activated inverse spinel phosphors.
Li C, Zhou Y, Tang F. Li C, et al. Opt Lett. 2024 Dec 15;49(24):6928-6931. doi: 10.1364/OL.544994. Opt Lett. 2024. PMID: 39671606
Lastly, the luminescence dynamics associated with anti-Stokes, ZPL, and Stokes emissions are analyzed. The observed increase in luminescence lifetime indicates a significant impact of the localized environment on luminescence properties....
Lastly, the luminescence dynamics associated with anti-Stokes, ZPL, and Stokes emissions are analyzed. The observed increase in lumin …
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