Bacterial citrullinated epitopes generated by Porphyromonas gingivalis infection-a missing link for ACPA production.
Jenning M, Marklein B, Ytterberg J, Zubarev RA, Joshua V, van Schaardenburg D, van de Stadt L, Catrina AI, Nonhoff U, Häupl T, Konthur Z, Burmester GR, Skriner K.
Jenning M, et al.
Ann Rheum Dis. 2020 Sep;79(9):1194-1202. doi: 10.1136/annrheumdis-2019-216919. Epub 2020 Jun 12.
Ann Rheum Dis. 2020.
PMID: 32532752
RESULTS: RA(CH2007)-PPAD was capable to citrullinate major RA autoantigens, such as fibrinogen, vimentin, hnRNP-A2/B1, histone H1 and multiple peptides, which identify a common RG/RGG consensus motif. 33% of RA patients (n=30) revealed increased reactivity for alpha-cit-RA(CH2007 …
RESULTS: RA(CH2007)-PPAD was capable to citrullinate major RA autoantigens, such as fibrinogen, vimentin, hnRNP-A2/B1, histone H1 and multip …