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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1970 1
1975 1
1976 1
1977 4
1978 1
1979 1
1980 1
1981 2
1982 1
1983 2
1984 6
1985 2
1986 1
1987 3
1988 4
1989 7
1990 5
1991 6
1992 3
1993 6
1994 3
1995 2
1996 3
1997 9
1998 4
1999 5
2000 5
2001 4
2002 7
2003 15
2004 10
2005 8
2006 17
2007 19
2008 14
2009 19
2010 11
2011 29
2012 41
2013 35
2014 44
2015 50
2016 48
2017 52
2018 39
2019 47
2020 41
2021 39
2022 53
2023 63
2024 39

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780 results

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The following term was not found in PubMed: straanded
Page 1
Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer.
Bowling EA, Wang JH, Gong F, Wu W, Neill NJ, Kim IS, Tyagi S, Orellana M, Kurley SJ, Dominguez-Vidaña R, Chung HC, Hsu TY, Dubrulle J, Saltzman AB, Li H, Meena JK, Canlas GM, Chamakuri S, Singh S, Simon LM, Olson CM, Dobrolecki LE, Lewis MT, Zhang B, Golding I, Rosen JM, Young DW, Malovannaya A, Stossi F, Miles G, Ellis MJ, Yu L, Buonamici S, Lin CY, Karlin KL, Zhang XH, Westbrook TF. Bowling EA, et al. Cell. 2021 Jan 21;184(2):384-403.e21. doi: 10.1016/j.cell.2020.12.031. Epub 2021 Jan 14. Cell. 2021. PMID: 33450205 Free PMC article.
In MYC-driven triple-negative breast cancer, STTs cause widespread cytoplasmic accumulation of mis-spliced mRNAs, many of which form double-stranded structures. Double-stranded RNA (dsRNA)-binding proteins recognize these endogenous dsRNAs, trig …
In MYC-driven triple-negative breast cancer, STTs cause widespread cytoplasmic accumulation of mis-spliced mRNAs, many of which form doub …
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer's disease: a phase 1b, randomized, placebo-controlled trial.
Mummery CJ, Börjesson-Hanson A, Blackburn DJ, Vijverberg EGB, De Deyn PP, Ducharme S, Jonsson M, Schneider A, Rinne JO, Ludolph AC, Bodenschatz R, Kordasiewicz H, Swayze EE, Fitzsimmons B, Mignon L, Moore KM, Yun C, Baumann T, Li D, Norris DA, Crean R, Graham DL, Huang E, Ratti E, Bennett CF, Junge C, Lane RM. Mummery CJ, et al. Nat Med. 2023 Jun;29(6):1437-1447. doi: 10.1038/s41591-023-02326-3. Epub 2023 Apr 24. Nat Med. 2023. PMID: 37095250 Free PMC article. Clinical Trial.
We sought to inhibit MAPT expression with a tau-targeting antisense oligonucleotide (MAPT(Rx)) and reduce tau levels in patients with mild AD. A randomized, double-blind, placebo-controlled, multiple-ascending dose phase 1b trial evaluated the safety, pharmacokinetics and …
We sought to inhibit MAPT expression with a tau-targeting antisense oligonucleotide (MAPT(Rx)) and reduce tau levels in patients with mild A …
Functional Enhancers Shape Extrachromosomal Oncogene Amplifications.
Morton AR, Dogan-Artun N, Faber ZJ, MacLeod G, Bartels CF, Piazza MS, Allan KC, Mack SC, Wang X, Gimple RC, Wu Q, Rubin BP, Shetty S, Angers S, Dirks PB, Sallari RC, Lupien M, Rich JN, Scacheri PC. Morton AR, et al. Cell. 2019 Nov 27;179(6):1330-1341.e13. doi: 10.1016/j.cell.2019.10.039. Epub 2019 Nov 21. Cell. 2019. PMID: 31761532 Free PMC article.
Using a computational approach, we find signatures of significant co-amplification of non-coding DNA beyond the boundaries of amplified oncogenes across five cancer types. In glioblastoma, EGFR is preferentially co-amplified with its two endogenous enhancer elements active …
Using a computational approach, we find signatures of significant co-amplification of non-coding DNA beyond the boundaries of amplifi …
Diabetic autonomic neuropathy.
Vinik AI, Maser RE, Mitchell BD, Freeman R. Vinik AI, et al. Diabetes Care. 2003 May;26(5):1553-79. doi: 10.2337/diacare.26.5.1553. Diabetes Care. 2003. PMID: 12716821 Review.
Diabetic autonomic neuropathy (DAN) is a serious and common complication of diabetes. Despite its relationship to an increased risk of cardiovascular mortality and its association with multiple symptoms and impairments, the significance of DAN has not been fully app …
Diabetic autonomic neuropathy (DAN) is a serious and common complication of diabetes. Despite its relationship to an increased risk o …
A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain.
Verrico CD, Wesson S, Konduri V, Hofferek CJ, Vazquez-Perez J, Blair E, Dunner K Jr, Salimpour P, Decker WK, Halpert MM. Verrico CD, et al. Pain. 2020 Sep 1;161(9):2191-2202. doi: 10.1097/j.pain.0000000000001896. Pain. 2020. PMID: 32345916 Free PMC article.
Subsequently, the therapeutic potential of both naked and liposomally encapsulated CBD was explored in a 4-week, randomized placebo-controlled, double-blinded study in a spontaneous canine model of OA. In vitro and in mouse models, CBD significantly attenuated the producti …
Subsequently, the therapeutic potential of both naked and liposomally encapsulated CBD was explored in a 4-week, randomized placebo-controll …
Anti-DNA antibodies exhibit different binding motif preferences for single stranded or double stranded DNA.
Wang Y, Mi J, Cao X. Wang Y, et al. Immunol Lett. 2000 Jul 3;73(1):29-34. doi: 10.1016/s0165-2478(00)00194-2. Immunol Lett. 2000. PMID: 10963808
A common feature for most anti-DNA antibodies (Abs) is their induction in an antigen (Ag)-driven specific clonal expansion pattern though crossreactivity. ...We show that the fragments of ss- or ds- form bound by a same stock of antibodies were diff …
A common feature for most anti-DNA antibodies (Abs) is their induction in an antigen (Ag)-driven specific clonal expans …
Tools To Live By: Bacterial DNA Structures Illuminate Cancer.
Xia J, Mei Q, Rosenberg SM. Xia J, et al. Trends Genet. 2019 May;35(5):383-395. doi: 10.1016/j.tig.2019.03.001. Epub 2019 Apr 5. Trends Genet. 2019. PMID: 30962000 Free PMC article. Review.
We review how an engineered protein that traps and labels HJs in Escherichia coli illuminates the biology of DNA and cancer. HJ chromatin immunoprecipitation with deep sequencing (ChIP-seq) analysis showed the directionality of double-strand break (DSB …
We review how an engineered protein that traps and labels HJs in Escherichia coli illuminates the biology of DNA and cancer. H …
Epilepsy in autism.
Tuchman R, Rapin I. Tuchman R, et al. Lancet Neurol. 2002 Oct;1(6):352-8. doi: 10.1016/s1474-4422(02)00160-6. Lancet Neurol. 2002. PMID: 12849396 Review.
There is no evidence-based treatment recommendation for individuals with autism, regression, and subclinical epilepsy. Double-blind studies with sufficient power to resolve this issue are urgently needed....
There is no evidence-based treatment recommendation for individuals with autism, regression, and subclinical epilepsy. Double-blind s …
Potential Benefits of Phytochemicals for Abdominal Aortic Aneurysm.
Hosseini A, Penson PE, Cicero AFG, Golledge J, Al-Rasadi K, Jamialahmadi T, Sahebkar A. Hosseini A, et al. Curr Med Chem. 2021;28(41):8595-8607. doi: 10.2174/0929867328666210614113116. Curr Med Chem. 2021. PMID: 34126879 Review.
RESULTS: Some preliminary data support the further investigation of curcumin, radix astragali, grape seed polyphenols, resveratrol, Ginkgo biloba extract (EGb 761), Ginsenoide Rb1, Dan Hong, Epigallocatechin-3-gallate, Baicalein, Fucoidan, Quercetin, and Salvianolic acid a …
RESULTS: Some preliminary data support the further investigation of curcumin, radix astragali, grape seed polyphenols, resveratrol, Ginkgo b …
Extrachromosomal Circular DNA: A New Target in Cancer.
Wu P, Liu Y, Zhou R, Liu L, Zeng H, Xiong F, Zhang S, Gong Z, Zhang W, Guo C, Wang F, Zhou M, Zu X, Zeng Z, Li Y, Li G, Huang H, Xiong W. Wu P, et al. Front Oncol. 2022 Apr 14;12:814504. doi: 10.3389/fonc.2022.814504. eCollection 2022. Front Oncol. 2022. PMID: 35494014 Free PMC article. Review.
Genomic instability and amplification are intrinsically important traits determining the development and heterogeneity of tumors. The role of extrachromosomal circular DNA (eccDNA) in tumors has recently been highlighted. EccDNAs are unique genetic materials located off th …
Genomic instability and amplification are intrinsically important traits determining the development and heterogeneity of tumors. The role o …
780 results