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Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms.
Zhang Y, Talalay P. Zhang Y, et al. Cancer Res. 1994 Apr 1;54(7 Suppl):1976s-1981s. Cancer Res. 1994. PMID: 8137323 Review.
The anticarcinogenic effects of isothiocyanates appear to be mediated by tandem and cooperating mechanisms: (a) suppression of carcinogen activation by cytochromes P-450, probably by a combination of down-regulation of enzyme levels and direct inhibiti …
The anticarcinogenic effects of isothiocyanates appear to be mediated by tandem and cooperating mechanisms: (a) suppres …
Neutrophil Immunomodulatory Activity of Natural Organosulfur Compounds.
Schepetkin IA, Kirpotina LN, Khlebnikov AI, Balasubramanian N, Quinn MT. Schepetkin IA, et al. Molecules. 2019 May 10;24(9):1809. doi: 10.3390/molecules24091809. Molecules. 2019. PMID: 31083328 Free PMC article.
Garlic EO, allyl propyl disulfide, dipropyl disulfide, diallyl disulfide, and allyl isothiocyanate (AITC) directly activated Ca(2+) flux in neutrophils, with the most potent being AITC. ...Our results demonstrate that certain organosulfur compounds can activate
Garlic EO, allyl propyl disulfide, dipropyl disulfide, diallyl disulfide, and allyl isothiocyanate (AITC) directly activated C …
Sulforaphane and Its Bifunctional Analogs: Synthesis and Biological Activity.
Janczewski Ł. Janczewski Ł. Molecules. 2022 Mar 7;27(5):1750. doi: 10.3390/molecules27051750. Molecules. 2022. PMID: 35268851 Free PMC article. Review.
The high chemopreventive and anticancer potential of cruciferous plants results from the presence of a large amount of glucosinolates, which, under the influence of myrosinase, undergo an enzymatic transformation to biologically active isothiocyanates (ITCs). Natura …
The high chemopreventive and anticancer potential of cruciferous plants results from the presence of a large amount of glucosinolates, which …
Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity.
Psurski M, Janczewski Ł, Świtalska M, Gajda A, Goszczyński TM, Oleksyszyn J, Wietrzyk J, Gajda T. Psurski M, et al. Eur J Med Chem. 2017 May 26;132:63-80. doi: 10.1016/j.ejmech.2017.03.028. Epub 2017 Mar 18. Eur J Med Chem. 2017. PMID: 28342398
A library of over forty, novel, structurally diverse phosphonate analogs of sulforaphane (P-ITCs) were designed, synthesized and fully characterized. All compounds were evaluated for antiproliferative activity in vitro on Lovo and LoVo/DX colon cancer cell lines. All compo …
A library of over forty, novel, structurally diverse phosphonate analogs of sulforaphane (P-ITCs) were designed, synthesized and fully chara …
Endophytic fungi from the roots of horseradish (Armoracia rusticana) and their interactions with the defensive metabolites of the glucosinolate - myrosinase - isothiocyanate system.
Szűcs Z, Plaszkó T, Cziáky Z, Kiss-Szikszai A, Emri T, Bertóti R, Sinka LT, Vasas G, Gonda S. Szűcs Z, et al. BMC Plant Biol. 2018 May 9;18(1):85. doi: 10.1186/s12870-018-1295-4. BMC Plant Biol. 2018. PMID: 29743024 Free PMC article.
Four endophytic strains also accepted sinigrin as the sole carbon source. Isothiocyanates inhibited the growth of fungi at various concentrations, phenylethyl isothiocyanate was more potent than allyl isothiocyanate (mean IC(50) was 2.30-fold lower). ...These …
Four endophytic strains also accepted sinigrin as the sole carbon source. Isothiocyanates inhibited the growth of fungi at various co …
Sulforaphane inhibits CYP1A1 activity and promotes genotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro.
Yang F, Zhuang S, Zhang C, Dai H, Liu W. Yang F, et al. Toxicol Appl Pharmacol. 2013 Jun 15;269(3):226-32. doi: 10.1016/j.taap.2013.03.024. Epub 2013 Apr 6. Toxicol Appl Pharmacol. 2013. PMID: 23566952
The results showed that SFN inhibited TCDD-induced CYP1A1 activity in H4IIE cells by directly inhibiting CYP1A1 activity, probably through binding to aryl hydrocarbon receptor and/or CYP1A1 revealed by molecular docking. ...Therefore, further studies should be urgen …
The results showed that SFN inhibited TCDD-induced CYP1A1 activity in H4IIE cells by directly inhibiting CYP1A1 activity, prob …
Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
Wang X, Yu C, Wang C, Ma Y, Wang T, Li Y, Huang Z, Zhou M, Sun P, Zheng J, Yang S, Fan Y, Xiang R. Wang X, et al. Eur J Med Chem. 2019 Nov 1;181:111535. doi: 10.1016/j.ejmech.2019.07.038. Epub 2019 Jul 25. Eur J Med Chem. 2019. PMID: 31376566
A series of novel, highly potent, selective CDK9 inhibitors with cancer stem cells (CSCs) inhibition activity were designed and synthesized for non-small-cell lung cancer (NSCLC) therapy. Structure-activity relationship analysis based on enzymatic and cellular ac
A series of novel, highly potent, selective CDK9 inhibitors with cancer stem cells (CSCs) inhibition activity were designed and synth …
Does molecular docking reveal alternative chemopreventive mechanism of activation of oxidoreductase by sulforaphane isothiocyanates?
Mazur P, Magdziarz T, Bak A, Chilmonczyk Z, Kasprzycka-Guttman T, Misiewicz-Krzemińska I, Skupińska K, Polanski J. Mazur P, et al. J Mol Model. 2010 Jul;16(7):1205-12. doi: 10.1007/s00894-009-0628-5. Epub 2009 Dec 22. J Mol Model. 2010. PMID: 20024690
Isothiocyanates (ITC) are well-known chemopreventive agents extracted from vegetables. This activity results from the activation of human oxidoreductase. In this letter, the uncompetitive activatory mechanism of ITC was investigated using dockin
Isothiocyanates (ITC) are well-known chemopreventive agents extracted from vegetables. This activity results from the