Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms.
Cancer Res. 1994.
PMID: 8137323
Review.
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Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms.
Cancer Res. 1994 Apr 1;54(7 Suppl):1976s-1981s.
Cancer Res. 1994.
PMID: 8137323
Review.
The anticarcinogenic effects of isothiocyanates appear to be mediated by tandem and cooperating mechanisms: (a) suppression of carcinogen activation by cytochromes P-450, probably by a combination of down-regulation of enzyme levels and direct inhibiti …
The anticarcinogenic effects of isothiocyanates appear to be mediated by tandem and cooperating mechanisms: (a) suppres …
Sulforaphane and Its Bifunctional Analogs: Synthesis and Biological Activity.
Molecules. 2022 Mar 7;27(5):1750. doi: 10.3390/molecules27051750.
Molecules. 2022.
PMID: 35268851
Free PMC article.
Review.
The high chemopreventive and anticancer potential of cruciferous plants results from the presence of a large amount of glucosinolates, which, under the influence of myrosinase, undergo an enzymatic transformation to biologically active isothiocyanates (ITCs). Natura …
The high chemopreventive and anticancer potential of cruciferous plants results from the presence of a large amount of glucosinolates, which …
Metabolomic and transcriptomic analysis of cold plasma promoting biosynthesis of active substances in broccoli sprouts.
Phytochem Anal. 2023 Dec;34(8):925-937. doi: 10.1002/pca.3256. Epub 2023 Jul 13.
Phytochem Anal. 2023.
PMID: 37443417
OBJECTIVE: The aim of this study was to increase the levels of active substances in broccoli sprouts and understand their metabolic mechanisms. METHODOLOGY: Metabolomics based on liquid chromatography-tandem mass spectrometry and transcriptome analysis were combined …
OBJECTIVE: The aim of this study was to increase the levels of active substances in broccoli sprouts and understand their metabolic …
Neutrophil Immunomodulatory Activity of Natural Organosulfur Compounds.
Molecules. 2019 May 10;24(9):1809. doi: 10.3390/molecules24091809.
Molecules. 2019.
PMID: 31083328
Free PMC article.
Garlic EO, allyl propyl disulfide, dipropyl disulfide, diallyl disulfide, and allyl isothiocyanate (AITC) directly activated Ca(2+) flux in neutrophils, with the most potent being AITC. ...Our results demonstrate that certain organosulfur compounds can activate …
Garlic EO, allyl propyl disulfide, dipropyl disulfide, diallyl disulfide, and allyl isothiocyanate (AITC) directly activated C …
Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity.
Eur J Med Chem. 2017 May 26;132:63-80. doi: 10.1016/j.ejmech.2017.03.028. Epub 2017 Mar 18.
Eur J Med Chem. 2017.
PMID: 28342398
All compounds were evaluated for antiproliferative activity in vitro on Lovo and LoVo/DX colon cancer cell lines. All compounds exhibited high antiproliferative activity, comparable or higher to the activity of naturally occurring benzyl isothiocyanate …
All compounds were evaluated for antiproliferative activity in vitro on Lovo and LoVo/DX colon cancer cell lines. All compounds exhib …
Extraction of weak hydrophobic sulforaphane from broccoli by salting-out assisted hydrophobic deep eutectic solvent extraction.
Food Chem. 2023 Mar 30;405(Pt A):134817. doi: 10.1016/j.foodchem.2022.134817. Epub 2022 Nov 4.
Food Chem. 2023.
PMID: 36370577
Under optimal conditions, 97.77 % of SFN was extracted by N(8881)Cl-EG DES and more than 82.5 % of SFN was recovered by activated carbon from DES. In addition, further studies with Kamlet-Taft parameters and density functional theory showed that the H-bond accepting capaci …
Under optimal conditions, 97.77 % of SFN was extracted by N(8881)Cl-EG DES and more than 82.5 % of SFN was recovered by activated car …
Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
Eur J Med Chem. 2019 Nov 1;181:111535. doi: 10.1016/j.ejmech.2019.07.038. Epub 2019 Jul 25.
Eur J Med Chem. 2019.
PMID: 31376566
A series of novel, highly potent, selective CDK9 inhibitors with cancer stem cells (CSCs) inhibition activity were designed and synthesized for non-small-cell lung cancer (NSCLC) therapy. Structure-activity relationship analysis based on enzymatic and cellular ac …
A series of novel, highly potent, selective CDK9 inhibitors with cancer stem cells (CSCs) inhibition activity were designed and synth …
Sulforaphane inhibits CYP1A1 activity and promotes genotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro.
Toxicol Appl Pharmacol. 2013 Jun 15;269(3):226-32. doi: 10.1016/j.taap.2013.03.024. Epub 2013 Apr 6.
Toxicol Appl Pharmacol. 2013.
PMID: 23566952
In this study, we studied the effects of SFN on CYP1A1 activity and genotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The results showed that SFN inhibited TCDD-induced CYP1A1 activity in H4IIE cells by directly inhibiting CYP1A1 activity, p …
In this study, we studied the effects of SFN on CYP1A1 activity and genotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD …
Endophytic fungi from the roots of horseradish (Armoracia rusticana) and their interactions with the defensive metabolites of the glucosinolate - myrosinase - isothiocyanate system.
BMC Plant Biol. 2018 May 9;18(1):85. doi: 10.1186/s12870-018-1295-4.
BMC Plant Biol. 2018.
PMID: 29743024
Free PMC article.
In the current study, we describe interactions of endophytic fungi with a widely researched chemical defense system, the glucosinolate - myrosinase - isothiocyanate system. The antifungal isothiocyanates are also of special interest because of their beneficial effec …
In the current study, we describe interactions of endophytic fungi with a widely researched chemical defense system, the glucosinolate - myr …
Does molecular docking reveal alternative chemopreventive mechanism of activation of oxidoreductase by sulforaphane isothiocyanates?
J Mol Model. 2010 Jul;16(7):1205-12. doi: 10.1007/s00894-009-0628-5. Epub 2009 Dec 22.
J Mol Model. 2010.
PMID: 20024690
Isothiocyanates (ITC) are well-known chemopreventive agents extracted from vegetables. This activity results from the activation of human oxidoreductase. In this letter, the uncompetitive activatory mechanism of ITC was investigated using dockin …
Isothiocyanates (ITC) are well-known chemopreventive agents extracted from vegetables. This activity results from the …
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