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Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms.
Zhang Y, Talalay P. Zhang Y, et al. Cancer Res. 1994 Apr 1;54(7 Suppl):1976s-1981s. Cancer Res. 1994. PMID: 8137323 Free article. Review.
The anticarcinogenic effects of isothiocyanates appear to be mediated by tandem and cooperating mechanisms: (a) suppression of carcinogen activation by cytochromes P-450, probably by a combination of down-regulation of enzyme levels and direct inhibiti …
The anticarcinogenic effects of isothiocyanates appear to be mediated by tandem and cooperating mechanisms: (a) suppres …
Neutrophil Immunomodulatory Activity of Natural Organosulfur Compounds.
Schepetkin IA, Kirpotina LN, Khlebnikov AI, Balasubramanian N, Quinn MT. Schepetkin IA, et al. Molecules. 2019 May 10;24(9):1809. doi: 10.3390/molecules24091809. Molecules. 2019. PMID: 31083328 Free PMC article.
Garlic EO, allyl propyl disulfide, dipropyl disulfide, diallyl disulfide, and allyl isothiocyanate (AITC) directly activated Ca(2+) flux in neutrophils, with the most potent being AITC. ...Our results demonstrate that certain organosulfur compounds can activate
Garlic EO, allyl propyl disulfide, dipropyl disulfide, diallyl disulfide, and allyl isothiocyanate (AITC) directly activated C …
Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
Wang X, Yu C, Wang C, Ma Y, Wang T, Li Y, Huang Z, Zhou M, Sun P, Zheng J, Yang S, Fan Y, Xiang R. Wang X, et al. Eur J Med Chem. 2019 Nov 1;181:111535. doi: 10.1016/j.ejmech.2019.07.038. Epub 2019 Jul 25. Eur J Med Chem. 2019. PMID: 31376566
Structure-activity relationship analysis based on enzymatic and cellular activities led to the discovery of a promising inhibitor 21e. 21e potently inhibited CDK9 with IC(50) value of 11 nM and suppressed the stemness properties of NSCLC effectively. ...Studies of …
Structure-activity relationship analysis based on enzymatic and cellular activities led to the discovery of a promising inhibi …
Endophytic fungi from the roots of horseradish (Armoracia rusticana) and their interactions with the defensive metabolites of the glucosinolate - myrosinase - isothiocyanate system.
Szűcs Z, Plaszkó T, Cziáky Z, Kiss-Szikszai A, Emri T, Bertóti R, Sinka LT, Vasas G, Gonda S. Szűcs Z, et al. BMC Plant Biol. 2018 May 9;18(1):85. doi: 10.1186/s12870-018-1295-4. BMC Plant Biol. 2018. PMID: 29743024 Free PMC article.
Isothiocyanates inhibited the growth of fungi at various concentrations, phenylethyl isothiocyanate was more potent than allyl isothiocyanate (mean IC(50) was 2.30-fold lower). ...These activities were much less apparent among the soil fungi. This sugg
Isothiocyanates inhibited the growth of fungi at various concentrations, phenylethyl isothiocyanate was more potent than allyl
Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity.
Psurski M, Janczewski Ł, Świtalska M, Gajda A, Goszczyński TM, Oleksyszyn J, Wietrzyk J, Gajda T. Psurski M, et al. Eur J Med Chem. 2017 May 26;132:63-80. doi: 10.1016/j.ejmech.2017.03.028. Epub 2017 Mar 18. Eur J Med Chem. 2017. PMID: 28342398
In vivo studies of the analyzed phosphonate analogs of sulforaphane showed lower activity in comparison with those of benzyl isothiocyanate. Our studies demonstrated that newly synthesized P-ITCs can be used for as a starting point for the synthesis of novel isot
In vivo studies of the analyzed phosphonate analogs of sulforaphane showed lower activity in comparison with those of benzyl isoth
Sulforaphane inhibits CYP1A1 activity and promotes genotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro.
Yang F, Zhuang S, Zhang C, Dai H, Liu W. Yang F, et al. Toxicol Appl Pharmacol. 2013 Jun 15;269(3):226-32. doi: 10.1016/j.taap.2013.03.024. Epub 2013 Apr 6. Toxicol Appl Pharmacol. 2013. PMID: 23566952
Besides, it is surprising that SFN also failed to reduce genotoxicity induced by other genotoxic reagents which possess different mechanisms to lead to DNA damage. ...Therefore, further studies should be urgent to reveal the function and mechanism of SFN in the stre …
Besides, it is surprising that SFN also failed to reduce genotoxicity induced by other genotoxic reagents which possess different mechani
Does molecular docking reveal alternative chemopreventive mechanism of activation of oxidoreductase by sulforaphane isothiocyanates?
Mazur P, Magdziarz T, Bak A, Chilmonczyk Z, Kasprzycka-Guttman T, Misiewicz-Krzemińska I, Skupińska K, Polanski J. Mazur P, et al. J Mol Model. 2010 Jul;16(7):1205-12. doi: 10.1007/s00894-009-0628-5. Epub 2009 Dec 22. J Mol Model. 2010. PMID: 20024690
Isothiocyanates (ITC) are well-known chemopreventive agents extracted from vegetables. This activity results from the activation of human oxidoreductase. In this letter, the uncompetitive activatory mechanism of ITC was investigated using dockin
Isothiocyanates (ITC) are well-known chemopreventive agents extracted from vegetables. This activity results from the
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