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Optogenetic stimulation of medial prefrontal cortex excites GABAergic cells in the nucleus accumbens and hippocampus of Wistar-Kyoto rats exposed to chronic mild stress.
Papp M, Gruca P, Lason M, Litwa E, Solecki W, Willner P. Papp M, et al. Psychopharmacology (Berl). 2022 Jul;239(7):2299-2307. doi: 10.1007/s00213-022-06116-6. Epub 2022 Mar 16. Psychopharmacology (Berl). 2022. PMID: 35292832
BACKGROUND: High frequency optogenetic stimulation (OGS) of prelimbic cortex (PLC) has been reported to exert antidepressant-like effects in the chronic mild stress model of depression in Wistar Kyoto (WKY) rats, which are non-responsive to a …
BACKGROUND: High frequency optogenetic stimulation (OGS) of prelimbic cortex (PLC) has been reported to exert antide …
Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects.
Hare BD, Shinohara R, Liu RJ, Pothula S, DiLeone RJ, Duman RS. Hare BD, et al. Nat Commun. 2019 Jan 15;10(1):223. doi: 10.1038/s41467-018-08168-9. Nat Commun. 2019. PMID: 30644390 Free PMC article.
Impaired function in the medial prefrontal cortex (mPFC) contributes to depression, and the therapeutic response produced by novel rapid-acting antidepressants such as ketamine are mediated by mPFC activity. ...In contrast, photostimulation of Drd2 exp …
Impaired function in the medial prefrontal cortex (mPFC) contributes to depression, and the therapeutic response produc …
Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex.
Covington HE 3rd, Lobo MK, Maze I, Vialou V, Hyman JM, Zaman S, LaPlant Q, Mouzon E, Ghose S, Tamminga CA, Neve RL, Deisseroth K, Nestler EJ. Covington HE 3rd, et al. J Neurosci. 2010 Dec 1;30(48):16082-90. doi: 10.1523/JNEUROSCI.1731-10.2010. J Neurosci. 2010. PMID: 21123555 Free PMC article.
Brain stimulation and imaging studies in humans have highlighted a key role for the prefrontal cortex in clinical depression; however, it remains unknown whether excitation or inhibition of prefrontal cortical neuronal activity is associated with an …
Brain stimulation and imaging studies in humans have highlighted a key role for the prefrontal cortex in clinical depre …
Insufficiency of ventral hippocampus to medial prefrontal cortex transmission explains antidepressant non-response.
Papp M, Gruca P, Lason M, Litwa E, Solecki W, Willner P. Papp M, et al. J Psychopharmacol. 2021 Oct;35(10):1253-1264. doi: 10.1177/02698811211048281. Epub 2021 Oct 7. J Psychopharmacol. 2021. PMID: 34617804 Free PMC article.
BACKGROUND: There is extensive evidence that antidepressant drugs restore normal brain function by repairing damage to ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC). While the damage is more extensive in hippocampus, the evidence of tr …
BACKGROUND: There is extensive evidence that antidepressant drugs restore normal brain function by repairing damage to ventral hippoc …
AMPA receptors mediate the pro-cognitive effects of electrical and optogenetic stimulation of the medial prefrontal cortex in antidepressant non-responsive Wistar-Kyoto rats.
Papp M, Gruca P, Lason M, Litwa E, Solecki W, Willner P. Papp M, et al. J Psychopharmacol. 2020 Dec;34(12):1418-1430. doi: 10.1177/0269881120967857. Epub 2020 Nov 17. J Psychopharmacol. 2020. PMID: 33200659 Free PMC article.
BACKGROUND: The chronic mild stress (CMS) procedure is a widely used animal model of depression, and its application in Wistar-Kyoto (WKY) rats has been validated as a model of antidepressant-refractory depression. While not responding to chronic treatment with antidepr …
BACKGROUND: The chronic mild stress (CMS) procedure is a widely used animal model of depression, and its application in Wistar-Kyoto (WKY) r …
Phasic dopamine release in the medial prefrontal cortex enhances stimulus discrimination.
Popescu AT, Zhou MR, Poo MM. Popescu AT, et al. Proc Natl Acad Sci U S A. 2016 May 31;113(22):E3169-76. doi: 10.1073/pnas.1606098113. Epub 2016 May 16. Proc Natl Acad Sci U S A. 2016. PMID: 27185946 Free PMC article.
Most studies have focused on projections from the ventral tegmental area (VTA) to the striatum, and the action of DA in other VTA target regions remains unclear. Using optogenetic activation of VTA projections, we examined DA function in the medial prefrontal …
Most studies have focused on projections from the ventral tegmental area (VTA) to the striatum, and the action of DA in other VTA target reg …
Optogenetic stimulation of transmission from prelimbic cortex to nucleus accumbens core overcomes resistance to venlafaxine in an animal model of treatment-resistant depression.
Papp M, Gruca P, Litwa E, Lason M, Willner P. Papp M, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2023 Apr 20;123:110715. doi: 10.1016/j.pnpbp.2023.110715. Epub 2023 Jan 4. Prog Neuropsychopharmacol Biol Psychiatry. 2023. PMID: 36610613
BACKGROUND: Our earlier study demonstrated that repeated optogenetic stimulation of afferents from ventral hippocampus (vHIP) to the prelimbic region of medial prefrontal cortex (mPFC) overcame resistance to antidepressant treatment in Wi …
BACKGROUND: Our earlier study demonstrated that repeated optogenetic stimulation of afferents from ventral hippocampus (vHIP) …
The stress susceptibility factor FKBP51 controls S-ketamine-evoked release of mBDNF in the prefrontal cortex of mice.
Anderzhanova E, Hafner K, Genewsky AJ, Soliman A, Pöhlmann ML, Schmidt MV, Blum R, Wotjak CT, Gassen NC. Anderzhanova E, et al. Neurobiol Stress. 2020 Jul 4;13:100239. doi: 10.1016/j.ynstr.2020.100239. eCollection 2020 Nov. Neurobiol Stress. 2020. PMID: 33344695 Free PMC article.
Withal, mBDNF secretion in the mPFC of mice was stimulated by a systemic administration of S-ketamine (10 or 50 mg/kg) or S-hydroxynorketamine (10 mg/kg). ...Moreover, the inability of S-ketamine to evoke a transient secretion in mBDNF in the mPFC in F …
Withal, mBDNF secretion in the mPFC of mice was stimulated by a systemic administration of S-ketamine (10 or 50 mg/kg) or S …
Effects of subanesthetic ketamine and (2R,6R) hydroxynorketamine on working memory and synaptic transmission in the nucleus reuniens in mice.
Goswamee P, Rice R, Leggett E, Zhang F, Manicka S, Porter JH, McQuiston AR. Goswamee P, et al. Neuropharmacology. 2022 May 1;208:108965. doi: 10.1016/j.neuropharm.2022.108965. Epub 2022 Jan 20. Neuropharmacology. 2022. PMID: 35065945
To determine the effect of the drug regimens on synaptic mechanisms in neural circuits deemed critical for SWM, we conducted patch-clamp electrophysiological recordings from neurons in the midline thalamic nucleus reuniens (RE) in response to optogenetic stimulat …
To determine the effect of the drug regimens on synaptic mechanisms in neural circuits deemed critical for SWM, we conducted patch-cl …