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Antidepressive effects of targeting ELK-1 signal transduction.
Apazoglou K, Farley S, Gorgievski V, Belzeaux R, Lopez JP, Grenier J, Ibrahim EC, El Khoury MA, Tse YC, Mongredien R, Barbé A, de Macedo CEA, Jaworski W, Bochereau A, Orrico A, Isingrini E, Guinaudie C, Mikasova L, Louis F, Gautron S, Groc L, Massaad C, Yildirim F, Vialou V, Dumas S, Marti F, Mechawar N, Morice E, Wong TP, Caboche J, Turecki G, Giros B, Tzavara ET. Apazoglou K, et al. Nat Med. 2018 May;24(5):591-597. doi: 10.1038/s41591-018-0011-0. Epub 2018 May 7. Nat Med. 2018. PMID: 29736027
Current antidepressants address specific symptoms of the disease, but there is vast room for improvement (1) . In this respect, new compounds that act beyond classical antidepressants to target signal transduction pathways governing synap …
Current antidepressants address specific symptoms of the disease, but there is vast room for improvement (1) . In this respect …
Commentary: Antidepressive effects of targeting ELK-1 signal transduction.
Cho CH. Cho CH. Front Mol Neurosci. 2018 Oct 12;11:384. doi: 10.3389/fnmol.2018.00384. eCollection 2018. Front Mol Neurosci. 2018. PMID: 30369870 Free PMC article. No abstract available.
LPA1 Mediates Antidepressant-Induced ERK1/2 Signaling and Protection from Oxidative Stress in Glial Cells.
Olianas MC, Dedoni S, Onali P. Olianas MC, et al. J Pharmacol Exp Ther. 2016 Nov;359(2):340-353. doi: 10.1124/jpet.116.236455. Epub 2016 Sep 7. J Pharmacol Exp Ther. 2016. PMID: 27605627
LPA(1) blockade prevented antidepressant-induced phosphorylation of the transcription factors CREB and Elk-1. Antidepressants and LPA signaling to ERK1/2 was abrogated by cell treatment with pertussis toxin and by the inhibition of fibroblast gr …
LPA(1) blockade prevented antidepressant-induced phosphorylation of the transcription factors CREB and Elk-1. …
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