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Amino acid metabolites, mTORC1 and aging.
Antikainen H, Khayati K, Dobrowolski R. Antikainen H, et al. Aging (Albany NY). 2017 Jul 17;9(7):1641-1642. doi: 10.18632/aging.101266. Aging (Albany NY). 2017. PMID: 28722657 Free PMC article. No abstract available.
TOR-mediated regulation of metabolism in aging.
Antikainen H, Driscoll M, Haspel G, Dobrowolski R. Antikainen H, et al. Aging Cell. 2017 Dec;16(6):1219-1233. doi: 10.1111/acel.12689. Epub 2017 Oct 2. Aging Cell. 2017. PMID: 28971552 Free PMC article. Review.
The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice.
Khayati K, Antikainen H, Bonder EM, Weber GF, Kruger WD, Jakubowski H, Dobrowolski R. Khayati K, et al. Among authors: antikainen h. FASEB J. 2017 Feb;31(2):598-609. doi: 10.1096/fj.201600915R. Epub 2016 Oct 25. FASEB J. 2017. PMID: 28148781
We conclude that an increase of intracellular Hcy levels predisposes neurons to develop abnormal protein aggregates, which are hallmarks of AD and its associated onset and pathophysiology with age.-Khayati, K., Antikainen, H., Bonder, E. M., Weber, G. F., Kruger, W. …
We conclude that an increase of intracellular Hcy levels predisposes neurons to develop abnormal protein aggregates, which are hallmarks of …
Subacute Transplantation of Native and Genetically Engineered Neural Progenitors Seeded on Microsphere Scaffolds Promote Repair and Functional Recovery After Traumatic Brain Injury.
Skop NB, Singh S, Antikainen H, Saqcena C, Calderon F, Rothbard DE, Cho CH, Gandhi CD, Levison SW, Dobrowolski R. Skop NB, et al. Among authors: antikainen h. ASN Neuro. 2019 Jan-Dec;11:1759091419830186. doi: 10.1177/1759091419830186. ASN Neuro. 2019. PMID: 30818968 Free PMC article.
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