Antonow D - Search Results

1

Synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).

Antonow D, Thurston DE. Antonow D, et al. Chem Rev. 2011 Apr 13;111(4):2815-64. doi: 10.1021/cr100120f. Epub 2010 Dec 17. Chem Rev. 2011. PMID: 21166464 Review. No abstract available.

2

Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents.

Antonow D, Kaliszczak M, Kang GD, Coffils M, Tiberghien AC, Cooper N, Barata T, Heidelberger S, James CH, Zloh M, Jenkins TC, Reszka AP, Neidle S, Guichard SM, Jodrell DI, Hartley JA, Howard PW, Thurston DE. Antonow D, et al. J Med Chem. 2010 Apr 8;53(7):2927-41. doi: 10.1021/jm901722v. J Med Chem. 2010. PMID: 20218628

3

Solution structure of a 2:1 C2-(2-naphthyl) pyrrolo[2,1-c][1,4]benzodiazepine DNA adduct: molecular basis for unexpectedly high DNA helix stabilization.

Antonow D, Barata T, Jenkins TC, Parkinson GN, Howard PW, Thurston DE, Zloh M. Antonow D, et al. Biochemistry. 2008 Nov 11;47(45):11818-29. doi: 10.1021/bi801225q. Epub 2008 Oct 17. Biochemistry. 2008. PMID: 18925745

4

Synthesis of a novel C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione library: effect of C2-aryl substitution on cytotoxicity and non-covalent DNA binding.

Antonow D, Jenkins TC, Howard PW, Thurston DE. Antonow D, et al. Bioorg Med Chem. 2007 Apr 15;15(8):3041-53. doi: 10.1016/j.bmc.2007.01.054. Epub 2007 Feb 2. Bioorg Med Chem. 2007. PMID: 17317191

5

Parallel synthesis of a novel C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) library.

Antonow D, Cooper N, Howard PW, Thurston DE. Antonow D, et al. J Comb Chem. 2007 May-Jun;9(3):437-45. doi: 10.1021/cc0601332. Epub 2007 Mar 31. J Comb Chem. 2007. PMID: 17397227

6

Facile oxidation of electron-poor benzo[b]thiophenes to the corresponding sulfones with an aqueous solution of H2O2 and P2O5.

Antonow D, Marrafa T, Dawood I, Ahmed T, Haque MR, Thurston DE, Zinzalla G. Antonow D, et al. Chem Commun (Camb). 2010 Apr 7;46(13):2289-91. doi: 10.1039/b924333j. Epub 2010 Jan 25. Chem Commun (Camb). 2010. PMID: 20234935

7

Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry.

Heidelberger S, Zinzalla G, Antonow D, Essex S, Basu BP, Palmer J, Husby J, Jackson PJ, Rahman KM, Wilderspin AF, Zloh M, Thurston DE. Heidelberger S, et al. Among authors: antonow d. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4719-22. doi: 10.1016/j.bmcl.2013.05.066. Epub 2013 May 29. Bioorg Med Chem Lett. 2013. PMID: 23810499

8

A novel small-molecule inhibitor of IL-6 signalling.

Zinzalla G, Haque MR, Basu BP, Anderson J, Kaye SL, Haider S, Hasan F, Antonow D, Essex S, Rahman KM, Palmer J, Morgenstern D, Wilderspin AF, Neidle S, Thurston DE. Zinzalla G, et al. Among authors: antonow d. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7029-32. doi: 10.1016/j.bmcl.2010.09.117. Epub 2010 Sep 29. Bioorg Med Chem Lett. 2010. PMID: 21030257

9

Optimization of the antitumor activity of sequence-specific pyrrolobenzodiazepine derivatives based on their affinity for ABC transporters.

Kaliszczak M, Antonow D, Patel KI, Howard P, Jodrell DI, Thurston DE, Guichard SM. Kaliszczak M, et al. Among authors: antonow d. AAPS J. 2010 Dec;12(4):617-27. doi: 10.1208/s12248-010-9225-x. Epub 2010 Aug 12. AAPS J. 2010. PMID: 20703960 Free PMC article.

10

Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine.

Hartley JA, Flynn MJ, Bingham JP, Corbett S, Reinert H, Tiberghien A, Masterson LA, Antonow D, Adams L, Chowdhury S, Williams DG, Mao S, Harper J, Havenith CEG, Zammarchi F, Chivers S, van Berkel PH, Howard PW. Hartley JA, et al. Among authors: antonow d. Sci Rep. 2018 Jul 11;8(1):10479. doi: 10.1038/s41598-018-28533-4. Sci Rep. 2018. PMID: 29992976 Free PMC article.

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