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Gαo potentiates estrogen receptor α activity via the ERK signaling pathway.
Bratton MR, Antoon JW, Duong BN, Frigo DE, Tilghman S, Collins-Burow BM, Elliott S, Tang Y, Melnik LI, Lai L, Alam J, Beckman BS, Hill SM, Rowan BG, McLachlan JA, Burow ME. Bratton MR, et al. J Endocrinol. 2012 Jul;214(1):45-54. doi: 10.1530/JOE-12-0097. Epub 2012 May 4. J Endocrinol. 2012. PMID: 22562654 Free PMC article.
Antiestrogenic activity of flavonoid phytochemicals mediated via the c-Jun N-terminal protein kinase pathway. Cell-type specific regulation of estrogen receptor alpha.
Collins-Burow BM, Antoon JW, Frigo DE, Elliott S, Weldon CB, Boue SM, Beckman BS, Curiel TJ, Alam J, McLachlan JA, Burow ME. Collins-Burow BM, et al. J Steroid Biochem Mol Biol. 2012 Oct;132(1-2):186-93. doi: 10.1016/j.jsbmb.2012.05.004. Epub 2012 May 24. J Steroid Biochem Mol Biol. 2012. PMID: 22634477 Free PMC article.
3-Ketone-4,6-diene ceramide analogs exclusively induce apoptosis in chemo-resistant cancer cells.
Ponnapakam AP, Liu J, Bhinge KN, Drew BA, Wang TL, Antoon JW, Nguyen TT, Dupart PS, Wang Y, Zhao M, Liu YY, Foroozesh M, Beckman BS. Ponnapakam AP, et al. Bioorg Med Chem. 2014 Feb 15;22(4):1412-20. doi: 10.1016/j.bmc.2013.12.065. Epub 2014 Jan 8. Bioorg Med Chem. 2014. PMID: 24457089 Free PMC article.
MEK5/ERK5 signaling suppresses estrogen receptor expression and promotes hormone-independent tumorigenesis.
Antoon JW, Martin EC, Lai R, Salvo VA, Tang Y, Nitzchke AM, Elliott S, Nam SY, Xiong W, Rhodes LV, Collins-Burow B, David O, Wang G, Shan B, Beckman BS, Nephew KP, Burow ME. Antoon JW, et al. PLoS One. 2013 Aug 9;8(8):e69291. doi: 10.1371/journal.pone.0069291. eCollection 2013. PLoS One. 2013. PMID: 23950888 Free PMC article.
Sphingosine kinase isoforms as a therapeutic target in endocrine therapy resistant luminal and basal-A breast cancer.
Antoon JW, White MD, Driver JL, Burow ME, Beckman BS. Antoon JW, et al. Exp Biol Med (Maywood). 2012 Jul;237(7):832-44. doi: 10.1258/ebm.2012.012028. Epub 2012 Aug 2. Exp Biol Med (Maywood). 2012. PMID: 22859737 Free PMC article.
Altered death receptor signaling promotes epithelial-to-mesenchymal transition and acquired chemoresistance.
Antoon JW, Lai R, Struckhoff AP, Nitschke AM, Elliott S, Martin EC, Rhodes LV, Yoon NS, Salvo VA, Shan B, Beckman BS, Nephew KP, Burow ME. Antoon JW, et al. Sci Rep. 2012;2:539. doi: 10.1038/srep00539. Epub 2012 Jul 27. Sci Rep. 2012. PMID: 22844580 Free PMC article.
Inhibition of p38-MAPK alters SRC coactivation and estrogen receptor phosphorylation.
Antoon JW, Bratton MR, Guillot LM, Wadsworth S, Salvo VA, Burow ME. Antoon JW, et al. Cancer Biol Ther. 2012 Sep;13(11):1026-33. doi: 10.4161/cbt.20992. Epub 2012 Jul 24. Cancer Biol Ther. 2012. PMID: 22825349 Free PMC article.
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