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Biological safety of LipoFullerene composed of squalane and fullerene-C60 upon mutagenesis, photocytotoxicity, and permeability into the human skin tissue.
Kato S, Aoshima H, Saitoh Y, Miwa N. Kato S, et al. Among authors: aoshima h. Basic Clin Pharmacol Toxicol. 2009 Jun;104(6):483-7. doi: 10.1111/j.1742-7843.2009.00396.x. Basic Clin Pharmacol Toxicol. 2009. PMID: 19371265
Fullerene-C60 incorporated in liposome exerts persistent hydroxyl radical-scavenging activity and cytoprotection in UVA/B-irradiated keratinocytes.
Kato S, Aoshima H, Saitoh Y, Miwa N. Kato S, et al. Among authors: aoshima h. J Nanosci Nanotechnol. 2011 May;11(5):3814-23. doi: 10.1166/jnn.2011.4172. J Nanosci Nanotechnol. 2011. PMID: 21780373
Highly hydroxylated fullerene localizes at the cytoskeleton and inhibits oxidative stress in adipocytes and a subcutaneous adipose-tissue equivalent.
Xiao L, Aoshima H, Saitoh Y, Miwa N. Xiao L, et al. Among authors: aoshima h. Free Radic Biol Med. 2011 Oct 1;51(7):1376-89. doi: 10.1016/j.freeradbiomed.2011.05.026. Epub 2011 May 27. Free Radic Biol Med. 2011. PMID: 21684329
Clinical evaluation of fullerene-C60 dissolved in squalane for anti-wrinkle cosmetics.
Kato S, Taira H, Aoshima H, Saitoh Y, Miwa N. Kato S, et al. Among authors: aoshima h. J Nanosci Nanotechnol. 2010 Oct;10(10):6769-74. doi: 10.1166/jnn.2010.3053. J Nanosci Nanotechnol. 2010. PMID: 21137794 Clinical Trial.
Novel polyhydroxylated fullerene suppresses intracellular oxidative stress together with repression of intracellular lipid accumulation during the differentiation of OP9 preadipocytes into adipocytes.
Saitoh Y, Xiao L, Mizuno H, Kato S, Aoshima H, Taira H, Kokubo K, Miwa N. Saitoh Y, et al. Among authors: aoshima h. Free Radic Res. 2010 Sep;44(9):1072-81. doi: 10.3109/10715762.2010.499905. Free Radic Res. 2010. PMID: 20815770
Fullerene-polyvinylpyrrolidone clathrate localizes in the cytoplasm to prevent Ultraviolet-A ray-induced DNA-fragmentation and activation of the transcriptional factor NF-kappaB.
Xiao L, Aoshima H, Saitoh Y, Miwa N. Xiao L, et al. Among authors: aoshima h. J Cell Biochem. 2010 Nov 1;111(4):955-66. doi: 10.1002/jcb.22784. J Cell Biochem. 2010. PMID: 20665670
Defensive effects of fullerene-C60 dissolved in squalane against the 2,4-nonadienal-induced cell injury in human skin keratinocytes HaCaT and wrinkle formation in 3D-human skin tissue model.
Kato S, Aoshima H, Saitoh Y, Miwa N. Kato S, et al. Among authors: aoshima h. J Biomed Nanotechnol. 2010 Feb;6(1):52-8. doi: 10.1166/jbn.2010.1091. J Biomed Nanotechnol. 2010. PMID: 20499832
The effect of squalane-dissolved fullerene-C60 on adipogenesis-accompanied oxidative stress and macrophage activation in a preadipocyte-monocyte co-culture system.
Xiao L, Aoshima H, Saitoh Y, Miwa N. Xiao L, et al. Among authors: aoshima h. Biomaterials. 2010 Aug;31(23):5976-85. doi: 10.1016/j.biomaterials.2010.04.032. Epub 2010 May 20. Biomaterials. 2010. PMID: 20488530
Defensive effects of fullerene-C60/liposome complex against UVA-induced intracellular reactive oxygen species generation and cell death in human skin keratinocytes HaCaT, associated with intracellular uptake and extracellular excretion of fullerene-C60.
Kato S, Kikuchi R, Aoshima H, Saitoh Y, Miwa N. Kato S, et al. Among authors: aoshima h. J Photochem Photobiol B. 2010 Feb 12;98(2):144-51. doi: 10.1016/j.jphotobiol.2009.11.015. Epub 2009 Dec 5. J Photochem Photobiol B. 2010. PMID: 20060738
Fullerene-C60/liposome complex: Defensive effects against UVA-induced damages in skin structure, nucleus and collagen type I/IV fibrils, and the permeability into human skin tissue.
Kato S, Aoshima H, Saitoh Y, Miwa N. Kato S, et al. Among authors: aoshima h. J Photochem Photobiol B. 2010 Jan 21;98(1):99-105. doi: 10.1016/j.jphotobiol.2009.11.010. Epub 2009 Dec 2. J Photochem Photobiol B. 2010. PMID: 20036139
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