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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.
Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, Nye JS, Curtis D. Francis R, et al. Among authors: apfeld j. Dev Cell. 2002 Jul;3(1):85-97. doi: 10.1016/s1534-5807(02)00189-2. Dev Cell. 2002. PMID: 12110170
The Caenorhabditis elegans Lifespan Machine.
Stroustrup N, Ulmschneider BE, Nash ZM, López-Moyado IF, Apfeld J, Fontana W. Stroustrup N, et al. Among authors: apfeld j. Nat Methods. 2013 Jul;10(7):665-70. doi: 10.1038/nmeth.2475. Epub 2013 May 12. Nat Methods. 2013. PMID: 23666410 Free PMC article.
An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology.
Fernandes de Abreu DA, Caballero A, Fardel P, Stroustrup N, Chen Z, Lee K, Keyes WD, Nash ZM, López-Moyado IF, Vaggi F, Cornils A, Regenass M, Neagu A, Ostojic I, Liu C, Cho Y, Sifoglu D, Shen Y, Fontana W, Lu H, Csikasz-Nagy A, Murphy CT, Antebi A, Blanc E, Apfeld J, Zhang Y, Alcedo J, Ch'ng Q. Fernandes de Abreu DA, et al. Among authors: apfeld j. PLoS Genet. 2014 Mar 27;10(3):e1004225. doi: 10.1371/journal.pgen.1004225. eCollection 2014 Mar. PLoS Genet. 2014. PMID: 24675767 Free PMC article.
The temporal scaling of Caenorhabditis elegans ageing.
Stroustrup N, Anthony WE, Nash ZM, Gowda V, Gomez A, López-Moyado IF, Apfeld J, Fontana W. Stroustrup N, et al. Among authors: apfeld j. Nature. 2016 Feb 4;530(7588):103-7. doi: 10.1038/nature16550. Epub 2016 Jan 27. Nature. 2016. PMID: 26814965 Free PMC article.
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