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2004 1
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60 results

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Page 1
Apigenin Ameliorates H(2)O(2)-Induced Oxidative Damage in Melanocytes through Nuclear Factor-E2-Related Factor 2 (Nrf2) and Phosphatidylinositol 3-Kinase (PI3K)/Protein Kinase B (Akt)/Mammalian Target of Rapamycin (mTOR) Pathways and Reducing the Generation of Reactive Oxygen Species (ROS) in Zebrafish.
Tang QQ, Wang ZD, An XH, Zhou XY, Zhang RZ, Zhan X, Zhang W, Zhou J. Tang QQ, et al. Pharmaceuticals (Basel). 2024 Sep 30;17(10):1302. doi: 10.3390/ph17101302. Pharmaceuticals (Basel). 2024. PMID: 39458943 Free PMC article.
Apigenin has antioxidant, anti-tumor, anti-inflammatory, and anticancer effects. In this research, we attempted to further investigate the effects of apigenin on the mechanism of repairing oxidative cell damage. The present study hopes to provide a potential candida …
Apigenin has antioxidant, anti-tumor, anti-inflammatory, and anticancer effects. In this research, we attempted to further investigat …
Apigenin ameliorates atherosclerosis by inhibiting macrophage foam cell formation in ApoE(-/-)mice fed a high fat diet.
Huang H, Ran F, Chen J, Wei Y, Wang J, Li W, Niu X. Huang H, et al. Arch Biochem Biophys. 2026 Mar;777:110730. doi: 10.1016/j.abb.2026.110730. Epub 2026 Jan 8. Arch Biochem Biophys. 2026. PMID: 41513215
BACKGROUND: Apigenin is a bioactive flavonoid and widely found in herbs, fruits, and vegetables. Accumulated evidences have demonstrated the protective potential of apigenin on cardiovascular diseases, but its role in atherosclerosis remains unclear. ...Apigenin …
BACKGROUND: Apigenin is a bioactive flavonoid and widely found in herbs, fruits, and vegetables. Accumulated evidences have demonstra …
The Flavonoid Apigenin Ameliorates Cisplatin-Induced Nephrotoxicity through Reduction of p53 Activation and Promotion of PI3K/Akt Pathway in Human Renal Proximal Tubular Epithelial Cells.
Ju SM, Kang JG, Bae JS, Pae HO, Lyu YS, Jeon BH. Ju SM, et al. Evid Based Complement Alternat Med. 2015;2015:186436. doi: 10.1155/2015/186436. Epub 2015 May 21. Evid Based Complement Alternat Med. 2015. PMID: 26089934 Free PMC article.
HK-2 cells were pretreated with apigenin (5, 10, 20 muM) for 1 h and then treated with 40 muM cisplatin for various times. ...Taken together, these results suggest that apigenin ameliorates cisplatin-induced apoptosis through reduction of p53 activatio …
HK-2 cells were pretreated with apigenin (5, 10, 20 muM) for 1 h and then treated with 40 muM cisplatin for various times. ... …
Apigenin Ameliorates Insulin Resistance in 3T3-L1 Adipocytes: Establishment of a New Insulin Resistance Model Induced by Combined Treatments.
Guo X, Xia B, Liu S, Dong Y, Qian Y, Qiu J. Guo X, et al. Mol Nutr Food Res. 2025 Mar;69(5):e202400545. doi: 10.1002/mnfr.202400545. Epub 2025 Feb 13. Mol Nutr Food Res. 2025. PMID: 39945085
Obesity-associated IR greatly attributes to low-grade inflammation and high circulating levels of FFAs and sugar. 3T3-L1 adipocytes exposed to a mixture of TNF-alpha, fructose, and palmitate acid for 24 h were validated as a model to simulate the pathogenesis of IR in obes …
Obesity-associated IR greatly attributes to low-grade inflammation and high circulating levels of FFAs and sugar. 3T3-L1 adipocytes exposed …
Apigenin ameliorates oxidative stress and mitochondrial damage induced by multiwall carbon nanotubes in rat kidney mitochondria.
Zamani F, Samiei F, Mousavi Z, Azari MR, Seydi E, Pourahmad J. Zamani F, et al. J Biochem Mol Toxicol. 2021 Jun;35(6):1-7. doi: 10.1002/jbt.22762. Epub 2021 Mar 16. J Biochem Mol Toxicol. 2021. PMID: 33724625
The toxicity of carbon nanotubes (CNTs) toward the mitochondria of the kidney is not fully recognized and still needs further research. Apigenin (APG) is known as a flavonoid compound and natural antioxidant. The purpose of this study was to assess the ameliorative …
The toxicity of carbon nanotubes (CNTs) toward the mitochondria of the kidney is not fully recognized and still needs further research. A …
Apigenin as an emerging hepatoprotective agent: current status and future perspectives.
Wang C, Feng X, Li W, Chen L, Wang X, Lan Y, Tang R, Jiang T, Zheng L, Liu G. Wang C, et al. Front Pharmacol. 2024 Dec 19;15:1508060. doi: 10.3389/fphar.2024.1508060. eCollection 2024. Front Pharmacol. 2024. PMID: 39749193 Free PMC article. Review.
Apigenin (C(15)H(10)O(5), API) is a natural flavonoid widely found in vegetables, fruits, and plants such as celery, oranges, and chamomile. ...The hepatoprotective effects of API involve multiple molecular mechanisms, including inhibition of inflammation, alleviati …
Apigenin (C(15)H(10)O(5), API) is a natural flavonoid widely found in vegetables, fruits, and plants such as celery, oranges, …
Vitexin alleviates MNNG-induced chronic atrophic gastritis via inhibiting NLRP3 inflammasome.
Liu J, Chen Y, Zhang J, Zheng Y, An Y, Xia C, Chen Y, Huang S, Hou S, Deng D. Liu J, et al. J Ethnopharmacol. 2025 Jan 31;340:119272. doi: 10.1016/j.jep.2024.119272. Epub 2024 Dec 21. J Ethnopharmacol. 2025. PMID: 39716512
MATERIALS AND METHODS: CAG was administered at a concentration of 170 mug/mL MNNG in the drinking water of rats, and the effects of vitexin (30 mg/kg, once daily for 6 weeks) on gastric tissues were subsequently analyzed. Pathological damage was assessed using H&E and …
MATERIALS AND METHODS: CAG was administered at a concentration of 170 mug/mL MNNG in the drinking water of rats, and the effects of vitexin …
Vitexin ameliorates PM2.5-triggered pulmonary toxicity through dual modulation of endoplasmic reticulum stress and ferroptosis pathways.
Wei X, Zhu T, Gao R, Zhang Y, Zhang Z, Wang H, Jiang T, Zhang L, Yu C, Guo J. Wei X, et al. Ecotoxicol Environ Saf. 2026 Jan 1;309:119558. doi: 10.1016/j.ecoenv.2025.119558. Epub 2025 Dec 13. Ecotoxicol Environ Saf. 2026. PMID: 41391365 Free article.
Concurrently, in vitro, BEAS-2B cells were pretreated with 30 muM VI and then exposed to PM2.5 supernatant (400 mug/mL) for 24 h, with cellular responses evaluated after standardized culture and viability assessment via CCK-8 assay. ...
Concurrently, in vitro, BEAS-2B cells were pretreated with 30 muM VI and then exposed to PM2.5 supernatant (400 mug/mL) for 24 h, wit …
Apigenin Alleviates Intestinal Ischemia/Reperfusion Injury via Upregulating Nrf2-Mediated Tight Junction Integrity.
Xu B, Zhuang Y, Zhang Y, Liu S, Fan R, Jiang W. Xu B, et al. Mol Nutr Food Res. 2025 May;69(9):e70043. doi: 10.1002/mnfr.70043. Epub 2025 Mar 27. Mol Nutr Food Res. 2025. PMID: 40150847
Apigenin protected against intestinal mucosal damage by suppressing inflammatory cytokines release (TNF-alpha, IL-1beta, IL-6, MPO, p < 0.01), ameliorating oxidative stress (MDA, SOD, GSH, GSH-Px, p < 0.01), and improving barrier dysfunction (DAO and TEER, p & …
Apigenin protected against intestinal mucosal damage by suppressing inflammatory cytokines release (TNF-alpha, IL-1beta, IL-6, MPO, p …
Yangxinshi Tablet protects against post-myocardial infarction heart failure with reduced ejection fraction by improving energy metabolism through inhibition of FOXO1/PDK4 signaling.
Guo J, Miao R, Fan Q, Li Y, Tian Y, Sun A, Zhang Q, Lv Z, Qi G, Francis OB, Liu R, Chen T, Liu Q, Li R, He J, Sun Y, Leng L, Jiang M, Wang Q. Guo J, et al. Chin J Nat Med. 2026 May;24(5):574-591. doi: 10.1016/S1875-5364(26)61119-3. Chin J Nat Med. 2026. PMID: 42062031
In vitro, YXS regulated mitochondrial energy metabolism and protected against oxygen-glucose deprivation (OGD)-induced cardiomyocyte injury. Notably, YXS ameliorated post-MI HF by inhibiting forkhead box O1 (FOXO1)/pyruvate dehydrogenase kinase 4 (PDK4) signaling, thereby …
In vitro, YXS regulated mitochondrial energy metabolism and protected against oxygen-glucose deprivation (OGD)-induced cardiomyocyte injury. …
60 results