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Page 1
Oligodendrocyte differentiation.
Mathews ES, Appel B. Mathews ES, et al. Among authors: appel b. Methods Cell Biol. 2016;134:69-96. doi: 10.1016/bs.mcb.2015.12.004. Epub 2016 Feb 28. Methods Cell Biol. 2016. PMID: 27312491
Therefore, an in vivo myelination model, such as the zebrafish, which allows for live observation of cell dynamics and cell-to-cell interactions, is well suited for investigating oligodendrocyte development. Zebrafish offer several advantages to investigating myelin …
Therefore, an in vivo myelination model, such as the zebrafish, which allows for live observation of cell dynamics and cell-to-cell i …
Cspg4 sculpts oligodendrocyte precursor cell morphology.
Bromley-Coolidge S, Iruegas D, Appel B. Bromley-Coolidge S, et al. Among authors: appel b. Differentiation. 2024 Nov-Dec;140:100819. doi: 10.1016/j.diff.2024.100819. Epub 2024 Nov 8. Differentiation. 2024. PMID: 39566199 Free PMC article.
Chondroitin sulfate proteoglycans (CSPGs), a major ECM component, have been implicated in modulating oligodendrocyte precursor cell (OPC) proliferation, migration, and maturation, but their specific roles in oligodendrocyte lineage cell (OLC) development and myelination in vivo r …
Chondroitin sulfate proteoglycans (CSPGs), a major ECM component, have been implicated in modulating oligodendrocyte precursor cell (OPC) pr …
Cspg4 sculpts oligodendrocyte precursor cell morphology.
Bromley-Coolidge S, Iruegas D, Appel B. Bromley-Coolidge S, et al. Among authors: appel b. bioRxiv [Preprint]. 2024 Aug 8:2024.08.08.607226. doi: 10.1101/2024.08.08.607226. bioRxiv. 2024. Update in: Differentiation. 2024 Nov-Dec;140:100819. doi: 10.1016/j.diff.2024.100819. PMID: 39149260 Free PMC article. Updated. Preprint.
Chondroitin sulfate proteoglycans (CSPGs), a major ECM component, have been implicated in modulating oligodendrocyte precursor cell (OPC) proliferation, migration, and maturation, but their specific roles in oligodendrocyte lineage cell (OLC) development and myelination in vivo r …
Chondroitin sulfate proteoglycans (CSPGs), a major ECM component, have been implicated in modulating oligodendrocyte precursor cell (OPC) pr …
Zebrafish neural induction and patterning.
Appel B. Appel B. Dev Dyn. 2000 Oct;219(2):155-68. doi: 10.1002/1097-0177(2000)9999:9999<::aid-dvdy1052>3.3.co;2-b. Dev Dyn. 2000. PMID: 11002336 Free article. Review.
A goal of developmental neurobiologists is to understand the nature of the patterning mechanisms that specify neural cells for particular fates. In recent years, zebrafish has emerged as new model system for investigating vertebrate neural development, offering a unique co …
A goal of developmental neurobiologists is to understand the nature of the patterning mechanisms that specify neural cells for particular fa …
Amyloid-beta Dysregulates Oligodendroglial Lineage Cell Dynamics and Myelination via PKC in the Zebrafish Spinal Cord.
Balantzategi U, Gaminde-Blasco A, Kearns CA, Bayón-Cordero L, Sánchez-Gómez MV, Zugaza JL, Appel B, Alberdi E. Balantzategi U, et al. Among authors: appel b. Glia. 2025 Jul;73(7):1437-1451. doi: 10.1002/glia.70015. Epub 2025 Mar 14. Glia. 2025. PMID: 40087862 Free PMC article.
Through live imaging of Tg(myrf:mScarlet) and Tg(mbpa:tagRFP) zebrafish lines, both crossed with Tg(olig2:EGFP), we found that Abeta increased the number of myrf (+) and mbp (+) OLs in the dorsal spinal cord at 72 hpf and 5 dpf, respectively, without affecting total cell n …
Through live imaging of Tg(myrf:mScarlet) and Tg(mbpa:tagRFP) zebrafish lines, both crossed with Tg(olig2:EGFP), we found that Abeta …
CNS myelination requires cytoplasmic dynein function.
Yang ML, Shin J, Kearns CA, Langworthy MM, Snell H, Walker MB, Appel B. Yang ML, et al. Among authors: appel b. Dev Dyn. 2015 Feb;244(2):134-45. doi: 10.1002/dvdy.24238. Dev Dyn. 2015. PMID: 25488883 Free PMC article.
However, whether oligodendrocytes require cytoplasmic dynein to ensheath axons with myelin is not known. RESULTS: We identified a mutation of zebrafish dync1h1 in a forward genetic screen that caused a deficit of oligodendrocytes. ...
However, whether oligodendrocytes require cytoplasmic dynein to ensheath axons with myelin is not known. RESULTS: We identified a mutation o …
Delta-Notch signaling regulates oligodendrocyte specification.
Park HC, Appel B. Park HC, et al. Among authors: appel b. Development. 2003 Aug;130(16):3747-55. doi: 10.1242/dev.00576. Development. 2003. PMID: 12835391
Although the mechanisms that specify motoneuron development are well described, the mechanisms that generate oligodendrocytes from the same precursor population are largely unknown. By analysing mutant zebrafish embryos, we found that Delta-Notch signaling is required for …
Although the mechanisms that specify motoneuron development are well described, the mechanisms that generate oligodendrocytes from the same …
Inositol polyphosphates regulate zebrafish left-right asymmetry.
Sarmah B, Latimer AJ, Appel B, Wente SR. Sarmah B, et al. Among authors: appel b. Dev Cell. 2005 Jul;9(1):133-45. doi: 10.1016/j.devcel.2005.05.002. Dev Cell. 2005. PMID: 15992547 Free article.
We report here that inositol 1,3,4,5,6-pentakisphosphate 2-kinase (Ipk1), which generates inositol hexakisphosphate, is critical for normal LR axis determination in zebrafish. Zebrafish embryos express ipk1 symmetrically during gastrulation and early segmentation. i …
We report here that inositol 1,3,4,5,6-pentakisphosphate 2-kinase (Ipk1), which generates inositol hexakisphosphate, is critical for normal …
Zebrafish spinal cord oligodendrocyte formation requires boc function.
Kearns CA, Walker M, Ravanelli AM, Scott K, Arzbecker MR, Appel B. Kearns CA, et al. Among authors: appel b. Genetics. 2021 Aug 9;218(4):iyab082. doi: 10.1093/genetics/iyab082. Genetics. 2021. PMID: 34057474 Free PMC article.
In addition to its role in patterning ventral progenitors, Shh signaling must be maintained through development to specify pMN progenitors for oligodendrocyte fate. Using a forward genetic screen in zebrafish for mutations that disrupt the development of oligodendrocytes, …
In addition to its role in patterning ventral progenitors, Shh signaling must be maintained through development to specify pMN progenitors f …
Distinct and redundant roles for zebrafish her genes during mineralization and craniofacial patterning.
Stenzel A, Mumme-Monheit A, Sucharov J, Walker M, Mitchell JM, Appel B, Nichols JT. Stenzel A, et al. Among authors: appel b. Front Endocrinol (Lausanne). 2022 Dec 12;13:1033843. doi: 10.3389/fendo.2022.1033843. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36578958 Free PMC article.
Notch receptor activation induces expression of several well-known canonical targets including those encoded by the hes and her genes in mammals and zebrafish, respectively. The function of these genes, individually and in combination, during craniofacial development is no …
Notch receptor activation induces expression of several well-known canonical targets including those encoded by the hes and her genes in mam …
80 results