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Activation of TRPA1 on dural afferents: a potential mechanism of headache pain.
Edelmayer RM, Le LN, Yan J, Wei X, Nassini R, Materazzi S, Preti D, Appendino G, Geppetti P, Dodick DW, Vanderah TW, Porreca F, Dussor G. Edelmayer RM, et al. Among authors: appendino g. Pain. 2012 Sep;153(9):1949-1958. doi: 10.1016/j.pain.2012.06.012. Epub 2012 Jul 17. Pain. 2012. PMID: 22809691 Free PMC article.
A controlled study of a lecithinized delivery system of curcumin (Meriva®) to alleviate the adverse effects of cancer treatment.
Belcaro G, Hosoi M, Pellegrini L, Appendino G, Ippolito E, Ricci A, Ledda A, Dugall M, Cesarone MR, Maione C, Ciammaichella G, Genovesi D, Togni S. Belcaro G, et al. Among authors: appendino g. Phytother Res. 2014 Mar;28(3):444-50. doi: 10.1002/ptr.5014. Epub 2013 Jun 15. Phytother Res. 2014. PMID: 23775598 Free article. Clinical Trial.
Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel.
Materazzi S, Benemei S, Fusi C, Gualdani R, De Siena G, Vastani N, Andersson DA, Trevisan G, Moncelli MR, Wei X, Dussor G, Pollastro F, Patacchini R, Appendino G, Geppetti P, Nassini R. Materazzi S, et al. Among authors: appendino g. Pain. 2013 Dec;154(12):2750-2758. doi: 10.1016/j.pain.2013.08.002. Epub 2013 Aug 8. Pain. 2013. PMID: 23933184 Free PMC article.
Ischemic neuroprotection by TRPV1 receptor-induced hypothermia.
Muzzi M, Felici R, Cavone L, Gerace E, Minassi A, Appendino G, Moroni F, Chiarugi A. Muzzi M, et al. Among authors: appendino g. J Cereb Blood Flow Metab. 2012 Jun;32(6):978-82. doi: 10.1038/jcbfm.2012.36. Epub 2012 Mar 21. J Cereb Blood Flow Metab. 2012. PMID: 22434066 Free PMC article.
The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel.
Benemei S, De Logu F, Li Puma S, Marone IM, Coppi E, Ugolini F, Liedtke W, Pollastro F, Appendino G, Geppetti P, Materazzi S, Nassini R. Benemei S, et al. Among authors: appendino g. Br J Pharmacol. 2017 Sep;174(17):2897-2911. doi: 10.1111/bph.13917. Epub 2017 Jul 20. Br J Pharmacol. 2017. PMID: 28622417 Free PMC article.
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.
Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andrè E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, Taglialatela-Scafati O, Appendino G, Nilius B, Geppetti P. Nassini R, et al. Among authors: appendino g. Brain. 2012 Feb;135(Pt 2):376-90. doi: 10.1093/brain/awr272. Epub 2011 Oct 27. Brain. 2012. PMID: 22036959
257 results