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Applying the auxin-inducible degradation system for rapid protein depletion in mammalian cells.
Lambrus BG, Moyer TC, Holland AJ. Lambrus BG, et al. Methods Cell Biol. 2018;144:107-135. doi: 10.1016/bs.mcb.2018.03.004. Epub 2018 Apr 5. Methods Cell Biol. 2018. PMID: 29804665
One of these systems, the auxin-inducible degron (AID) system, has been shown to permit rapid and inducible degradation of AID-tagged target proteins in mammalian cells. The AID system can control the ab …
One of these systems, the auxin-inducible degron (AID) system, has been shown to permit rapid and indu …
The auxin-inducible degradation system enables conditional PERIOD protein depletion in the nervous system of Drosophila melanogaster.
Chen W, Werdann M, Zhang Y. Chen W, et al. FEBS J. 2018 Dec;285(23):4378-4393. doi: 10.1111/febs.14677. Epub 2018 Oct 25. FEBS J. 2018. PMID: 30321477 Free PMC article.
The plant-derived auxin-inducible degradation system (AID) enables the degradation of target proteins tagged with the AID motif. ...Furthermore, the protein degradation by AID was rapidly reversible after auxin remova …
The plant-derived auxin-inducible degradation system (AID) enables the degradation of target proteins …
A super-sensitive auxin-inducible degron system with an engineered auxin-TIR1 pair.
Nishimura K, Yamada R, Hagihara S, Iwasaki R, Uchida N, Kamura T, Takahashi K, Torii KU, Fukagawa T. Nishimura K, et al. Nucleic Acids Res. 2020 Oct 9;48(18):e108. doi: 10.1093/nar/gkaa748. Nucleic Acids Res. 2020. PMID: 32941625 Free PMC article.
The auxin-inducible degron (AID) system enables rapid depletion of target proteins within the cell by applying the natural auxin IAA. The AID system is useful for investigating the physiological functions of es …
The auxin-inducible degron (AID) system enables rapid depletion of target proteins within the c …