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Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets.
Dardenne O, Prud'homme J, Arabian A, Glorieux FH, St-Arnaud R. Dardenne O, et al. Among authors: arabian a. Endocrinology. 2001 Jul;142(7):3135-41. doi: 10.1210/endo.142.7.8281. Endocrinology. 2001. PMID: 11416036
Influence of calcitriol on prolactin and prostaglandin production by human decidua.
Delvin EE, Gagnon L, Arabian A, Gibb W. Delvin EE, et al. Among authors: arabian a. Mol Cell Endocrinol. 1990 Jul 9;71(3):177-83. doi: 10.1016/0303-7207(90)90023-2. Mol Cell Endocrinol. 1990. PMID: 2170210
Pseudo-vitamin D deficiency: absence of 25-hydroxyvitamin D 1 alpha-hydroxylase activity in human placenta decidual cells.
Glorieux FH, Arabian A, Delvin EE. Glorieux FH, et al. Among authors: arabian a. J Clin Endocrinol Metab. 1995 Jul;80(7):2255-8. doi: 10.1210/jcem.80.7.7608289. J Clin Endocrinol Metab. 1995. PMID: 7608289
Rat kidney 25-hydroxyvitamin D3 1 alpha- and 24-hydroxylases: evidence for two distinct gene products.
Arabian A, Grover J, Barré MG, Delvin EE. Arabian A, et al. J Steroid Biochem Mol Biol. 1993 Jun;45(6):513-6. doi: 10.1016/0960-0760(93)90167-u. J Steroid Biochem Mol Biol. 1993. PMID: 7686041
Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D.
St-Arnaud R, Arabian A, Travers R, Barletta F, Raval-Pandya M, Chapin K, Depovere J, Mathieu C, Christakos S, Demay MB, Glorieux FH. St-Arnaud R, et al. Among authors: arabian a. Endocrinology. 2000 Jul;141(7):2658-66. doi: 10.1210/endo.141.7.7579. Endocrinology. 2000. PMID: 10875271
Altered pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouse.
Masuda S, Byford V, Arabian A, Sakai Y, Demay MB, St-Arnaud R, Jones G. Masuda S, et al. Among authors: arabian a. Endocrinology. 2005 Feb;146(2):825-34. doi: 10.1210/en.2004-1116. Epub 2004 Oct 21. Endocrinology. 2005. PMID: 15498883
1α,24(S)(OH)2D2 normalizes bone morphology and serum parathyroid hormone without hypercalcemia in 25-hydroxyvitamin D-1-hydroxylase (CYP27B1)-deficient mice, an animal model of vitamin D deficiency with secondary hyperparathyroidism.
St-Arnaud R, Arabian A, Yu VW, Akhouayri O, Knutson JC, Strugnell SA. St-Arnaud R, et al. Among authors: arabian a. J Endocrinol Invest. 2008 Aug;31(8):711-7. doi: 10.1007/BF03346420. J Endocrinol Invest. 2008. PMID: 18852532
Chondrocyte-specific modulation of Cyp27b1 expression supports a role for local synthesis of 1,25-dihydroxyvitamin D3 in growth plate development.
Naja RP, Dardenne O, Arabian A, St Arnaud R. Naja RP, et al. Among authors: arabian a. Endocrinology. 2009 Sep;150(9):4024-32. doi: 10.1210/en.2008-1410. Epub 2009 May 28. Endocrinology. 2009. PMID: 19477943
Differential effects of oral doxercalciferol (Hectorol) or paricalcitol (Zemplar) in the Cyp27b1-null mouse model of uremia.
St-Arnaud R, Arabian A, Akhouayri O, Knutson JC, Strugnell SA. St-Arnaud R, et al. Among authors: arabian a. Nephron Exp Nephrol. 2011;119(3):e67-74. doi: 10.1159/000329663. Epub 2011 Aug 18. Nephron Exp Nephrol. 2011. PMID: 21849802
FIAT Deletion Increases Bone Mass But Does Not Prevent High-Fat-Diet-Induced Metabolic Complications.
Hekmatnejad B, Yu VW, Addison W, Mandic V, Pellicelli M, Arabian A, St-Arnaud R. Hekmatnejad B, et al. Among authors: arabian a. Endocrinology. 2017 Feb 1;158(2):264-276. doi: 10.1210/en.2016-1867. Endocrinology. 2017. PMID: 27906582 Free PMC article.
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