Araki T - Search Results

1

Sticking It to Cancer with Molecular Glue for SHP2.

Ran H, Tsutsumi R, Araki T, Neel BG. Ran H, et al. Among authors: araki t. Cancer Cell. 2016 Aug 8;30(2):194-196. doi: 10.1016/j.ccell.2016.07.010. Cancer Cell. 2016. PMID: 27505669 Free PMC article.

2

The Noonan Syndrome-linked Raf1L613V mutation drives increased glial number in the mouse cortex and enhanced learning.

Holter MC, Hewitt LT, Koebele SV, Judd JM, Xing L, Bimonte-Nelson HA, Conrad CD, Araki T, Neel BG, Snider WD, Newbern JM. Holter MC, et al. Among authors: araki t. PLoS Genet. 2019 Apr 24;15(4):e1008108. doi: 10.1371/journal.pgen.1008108. eCollection 2019 Apr. PLoS Genet. 2019. PMID: 31017896 Free PMC article.

3

Noonan syndrome-causing SHP2 mutants impair ERK-dependent chondrocyte differentiation during endochondral bone growth.

Tajan M, Pernin-Grandjean J, Beton N, Gennero I, Capilla F, Neel BG, Araki T, Valet P, Tauber M, Salles JP, Yart A, Edouard T. Tajan M, et al. Among authors: araki t. Hum Mol Genet. 2018 Jul 1;27(13):2276-2289. doi: 10.1093/hmg/ddy133. Hum Mol Genet. 2018. PMID: 29659837 Free PMC article.

4

Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors.

Araki T, Nawa H, Neel BG. Araki T, et al. J Biol Chem. 2003 Oct 24;278(43):41677-84. doi: 10.1074/jbc.M306461200. Epub 2003 Aug 14. J Biol Chem. 2003. PMID: 12923167

5

Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.

Zhang SQ, Tsiaras WG, Araki T, Wen G, Minichiello L, Klein R, Neel BG. Zhang SQ, et al. Among authors: araki t. Mol Cell Biol. 2002 Jun;22(12):4062-72. doi: 10.1128/MCB.22.12.4062-4072.2002. Mol Cell Biol. 2002. PMID: 12024020 Free PMC article.

6

An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival.

Yang W, Klaman LD, Chen B, Araki T, Harada H, Thomas SM, George EL, Neel BG. Yang W, et al. Among authors: araki t. Dev Cell. 2006 Mar;10(3):317-27. doi: 10.1016/j.devcel.2006.01.002. Dev Cell. 2006. PMID: 16516835

7

Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment.

Zhang SQ, Yang W, Kontaridis MI, Bivona TG, Wen G, Araki T, Luo J, Thompson JA, Schraven BL, Philips MR, Neel BG. Zhang SQ, et al. Among authors: araki t. Mol Cell. 2004 Feb 13;13(3):341-55. doi: 10.1016/s1097-2765(04)00050-4. Mol Cell. 2004. PMID: 14967142

8

Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.

De Rocca Serra-Nédélec A, Edouard T, Tréguer K, Tajan M, Araki T, Dance M, Mus M, Montagner A, Tauber M, Salles JP, Valet P, Neel BG, Raynal P, Yart A. De Rocca Serra-Nédélec A, et al. Among authors: araki t. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4257-62. doi: 10.1073/pnas.1119803109. Epub 2012 Feb 27. Proc Natl Acad Sci U S A. 2012. PMID: 22371576 Free PMC article.

9

Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome.

Yin JC, Platt MJ, Tian X, Wu X, Backx PH, Simpson JA, Araki T, Neel BG. Yin JC, et al. Among authors: araki t. Nat Commun. 2017 May 26;8:15518. doi: 10.1038/ncomms15518. Nat Commun. 2017. PMID: 28548091 Free PMC article.

10

Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation.

Araki T, Chan G, Newbigging S, Morikawa L, Bronson RT, Neel BG. Araki T, et al. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4736-41. doi: 10.1073/pnas.0810053106. Epub 2009 Feb 27. Proc Natl Acad Sci U S A. 2009. PMID: 19251646 Free PMC article.

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