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Sticking It to Cancer with Molecular Glue for SHP2.
Ran H, Tsutsumi R, Araki T, Neel BG. Ran H, et al. Among authors: araki t. Cancer Cell. 2016 Aug 8;30(2):194-196. doi: 10.1016/j.ccell.2016.07.010. Cancer Cell. 2016. PMID: 27505669 Free PMC article.
Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.
De Rocca Serra-Nédélec A, Edouard T, Tréguer K, Tajan M, Araki T, Dance M, Mus M, Montagner A, Tauber M, Salles JP, Valet P, Neel BG, Raynal P, Yart A. De Rocca Serra-Nédélec A, et al. Among authors: araki t. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4257-62. doi: 10.1073/pnas.1119803109. Epub 2012 Feb 27. Proc Natl Acad Sci U S A. 2012. PMID: 22371576 Free PMC article.
2,427 results