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Aralia cordata inhibits triacylglycerol biosynthesis in HepG2 cells.
Kim MO, Lee SH, Seo JH, Kim IS, Han AR, Moon DO, Cho S, Cui L, Kim J, Lee HS. Kim MO, et al. J Med Food. 2013 Dec;16(12):1108-14. doi: 10.1089/jmf.2012.2636. Epub 2013 Nov 27. J Med Food. 2013. PMID: 24283275 Free PMC article.
The aim of this study was to investigate the GPAT inhibitors from natural products and to evaluate their effects. The methanol extract of Aralia cordata roots showed a strong inhibitory effect on the human GPAT1 activity. A further bioactivity-guided approach led to …
The aim of this study was to investigate the GPAT inhibitors from natural products and to evaluate their effects. The methanol extract of …
Therapeutic effect of Aralia cordata extracts on cartilage protection in collagenase-induced inflammatory arthritis rabbit model.
Park DS, Huh JE, Baek YH. Park DS, et al. J Ethnopharmacol. 2009 Sep 7;125(2):207-17. doi: 10.1016/j.jep.2009.07.010. Epub 2009 Jul 18. J Ethnopharmacol. 2009. PMID: 19619632
AIM OF THIS STUDY: Aralia cordata has been used to alleviate symptoms of osteoarthritis (OA) in traditional medicine. However, there is no in vivo study related with the therapeutic effects and mechanisms of Aralia cordata. On the basis of this backgro …
AIM OF THIS STUDY: Aralia cordata has been used to alleviate symptoms of osteoarthritis (OA) in traditional medicine. However, …
Aralia cordata protects against amyloid beta protein (25-35)-induced neurotoxicity in cultured neurons and has antidementia activities in mice.
Cho SO, Ban JY, Kim JY, Jeong HY, Lee IS, Song KS, Bae K, Seong YH. Cho SO, et al. J Pharmacol Sci. 2009 Sep;111(1):22-32. doi: 10.1254/jphs.08271fp. J Pharmacol Sci. 2009. PMID: 19763045 Free article.
The present study investigated an ethanol extract of the aerial part of Aralia cordata Thunb. (Araliaceae) for possible neuroprotective effects on neurotoxicity induced by amyloid beta (Abeta) protein (25 - 35) in cultured rat cortical neurons and antidementia activ …
The present study investigated an ethanol extract of the aerial part of Aralia cordata Thunb. (Araliaceae) for possible neurop …
Anti-ischemic activities of aralia cordata and its active component, oleanolic acid.
Cho SO, Ban JY, Kim JY, Ju HS, Lee IS, Song KS, Bae K, Seong YH. Cho SO, et al. Arch Pharm Res. 2009 Jun;32(6):923-32. doi: 10.1007/s12272-009-1615-1. Epub 2009 Jun 26. Arch Pharm Res. 2009. PMID: 19557371
We performed in vitro and in vivo analyses on the neuroprotective effects of an ethanolic extract of the aerial parts of Aralia cordata Thunb. (Araliaceae). In cultured cortical neurons from rats, A. cordata (5-20 microg/mL) inhibited 100 muM hydrogen peroxid …
We performed in vitro and in vivo analyses on the neuroprotective effects of an ethanolic extract of the aerial parts of Aralia co
Effect of Aralia cordata extracts on cartilage protection and apoptosis inhibition.
Baek YH, Huh JE, Lee JD, Choi DY, Park DS. Baek YH, et al. Biol Pharm Bull. 2006 Jul;29(7):1423-30. doi: 10.1248/bpb.29.1423. Biol Pharm Bull. 2006. PMID: 16819182 Free article.
Anti-apoptotic effects of Aralia cordata were determined by measuring (1) JNK and p38 MAP kinase expression, (2) apoptotic cells by flow cytometry, and (3) caspase-3 activity. ...Also, Aralia cordata inhibited the chondrocyte apoptosis through the down …
Anti-apoptotic effects of Aralia cordata were determined by measuring (1) JNK and p38 MAP kinase expression, (2) apoptotic cel …
Diterpenoids and Diacetylenes from the Roots of Aralia cordata with Inhibitory Effects on Nitric Oxide Production.
Kim JG, Lee JW, Le TPL, Han JS, Kwon H, Lee D, Hong JT, Kim Y, Lee MK, Hwang BY. Kim JG, et al. J Nat Prod. 2021 Feb 26;84(2):230-238. doi: 10.1021/acs.jnatprod.0c00842. Epub 2021 Jan 21. J Nat Prod. 2021. PMID: 33476145
Bioactivity-guided isolation of a MeOH extract of Aralia cordata led to the isolation of four new ent-pimarane diterpenoids (1-4) and a diacetylene (5) together with 21 known compounds (6-26). ...
Bioactivity-guided isolation of a MeOH extract of Aralia cordata led to the isolation of four new ent-pimarane diterpenoids (1 …
Cholinesterase and BACE1 inhibitory diterpenoids from Aralia cordata.
Jung HA, Lee EJ, Kim JS, Kang SS, Lee JH, Min BS, Choi JS. Jung HA, et al. Arch Pharm Res. 2009 Oct;32(10):1399-408. doi: 10.1007/s12272-009-2009-0. Epub 2009 Nov 8. Arch Pharm Res. 2009. PMID: 19898803
Fourteen diterpenes were isolated from the n-hexane fraction of the roots of Aralia cordata (syn. = A. continentalis). Through spectroscopy, the chemical structures were determined as: ent-pimara-8(14),15-diene-19-oic acid (1); ent-kaur-16-en-19-oic-acid (2); 18-nor …
Fourteen diterpenes were isolated from the n-hexane fraction of the roots of Aralia cordata (syn. = A. continentalis). Through …
Inhibitory constituents against cyclooxygenases from Aralia cordata Thunb.
Dang NH, Zhang X, Zheng M, Son KH, Chang HW, Kim HP, Bae K, Kang SS. Dang NH, et al. Arch Pharm Res. 2005 Jan;28(1):28-33. doi: 10.1007/BF02975131. Arch Pharm Res. 2005. PMID: 15742804
Seven diterpenes, four polyacetylenes, a lipid glycerol, and two sterols were isolated from the methylene chloride fraction of the root of Aralia cordata. Their chemical structures were determined as (-)-pimara-8(14),15-dien-19-oic acid (2), pimaric acid (3), (-)-ka …
Seven diterpenes, four polyacetylenes, a lipid glycerol, and two sterols were isolated from the methylene chloride fraction of the root of …
Pimaric acid from Aralia cordata has an inhibitory effect on TNF-alpha-induced MMP-9 production and HASMC migration via down-regulated NF-kappaB and AP-1.
Suh SJ, Kwak CH, Chung TW, Park SJ, Cheeeei M, Park SS, Seo CS, Son JK, Chang YC, Park YG, Lee YC, Chang HW, Kim CH. Suh SJ, et al. Chem Biol Interact. 2012 Aug 30;199(2):112-9. doi: 10.1016/j.cbi.2012.06.003. Epub 2012 Jun 13. Chem Biol Interact. 2012. PMID: 22705379
In this study, we revealed that pimaric acid (PiMA) purified from Aralia cordata had an inhibitory effect on MMP-9 production and migration of human aortic smooth muscle cells (HASMCs) induced by tumor necrosis factor (TNF)-alpha. ...
In this study, we revealed that pimaric acid (PiMA) purified from Aralia cordata had an inhibitory effect on MMP-9 production …
The analgesic and anti-inflammatory effects of 7-oxosandaracopimaric acid isolated from the roots of Aralia cordata.
Kim TD, Lee JY, Cho BJ, Park TW, Kim CJ. Kim TD, et al. Arch Pharm Res. 2010 Apr;33(4):509-14. doi: 10.1007/s12272-010-0403-2. Epub 2010 Apr 27. Arch Pharm Res. 2010. PMID: 20422358
The root of Aralia cordata is a traditional medicine for the treatment of inflammation, fever, pain, and spasm in the various diseases in Korea. We isolated a dibenzylbutyrolactone diterpene acid, 7-oxosandaracopimaric acid (OSA), from the ether fraction of Arali
The root of Aralia cordata is a traditional medicine for the treatment of inflammation, fever, pain, and spasm in the various …
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