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Page 1
Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles.
Billmann M, Costanzo M, Zhang X, Hassan AZ, Rahman M, Brown KR, Chan KS, Tong AHY, Pons C, Ward HN, Ross C, van Leeuwen J, Aregger M, Lawson KA, Mair B, Roth AF, Sen NE, Forster DT, Tan G, Mero P, Masud SN, Lee Y, Aguilera-Uribe M, Ušaj M, Almeida SMT, Aulakh K, Bhojoo U, Birkadze S, Budijono N, Cai X, Caumanns JJ, Chalmers JJ, Chandrashekhar M, Chang D, Climie R, Dasgupta K, Drazic A, Echenique JIR, Gacesa R, Farias AG, Habsid A, Horecka I, Kantautas K, Ji F, Kim DK, Lee SY, Liang W, Lim HJ, Lin K, Lu X, Maier M, Nami B, Nixon A, Mikolajewicz N, Mokhtaridoost M, Nedyalkova L, Rohde T, Rodrigues MS, Soste M, Schultz E, Wang W, Seetharaman A, Shuteriqi E, Sizova O, Taylor DT, Tereshchenko M, Tieu D, Turowec J, Ubhi T, Varland S, Wang KE, Wang ZY, Wei J, Xiao YX, Maass PG, Reversade B, Brown GW, Cravatt BF, Dixon SJ, Wyatt HDM, Röst HL, Roth FP, Xia T, Bader GD, Loewith R, Davis NG, Andrews B, Myers CL, Moffat J, Boone C. Billmann M, et al. Among authors: aregger m. Cell. 2026 Apr 27:S0092-8674(26)00345-4. doi: 10.1016/j.cell.2026.03.044. Online ahead of print. Cell. 2026. PMID: 42049019 Free article.
Quantitative analysis of genetic interactions in human cells from genome-wide CRISPR-Cas9 screens.
Billmann M, Costanzo M, Rahman M, Chan K, Yan Tong AH, Ward HN, Hassan AZ, Zhang X, Brown KR, Rohde T, Shaw AH, Ross C, van Leeuwen J, Aregger M, Lawson K, Mair B, Mero P, Usaj M, Andrews B, Boone C, Moffat J, Myers CL. Billmann M, et al. Among authors: aregger m. bioRxiv [Preprint]. 2026 Jan 5:2025.06.30.662330. doi: 10.1101/2025.06.30.662330. bioRxiv. 2026. PMID: 41542642 Free PMC article. Preprint.
A global genetic interaction map of a human cell reveals conserved principles of genetic networks.
Billmann M, Costanzo M, Zhang X, Hassan AZ, Rahman M, Brown KR, Chan KS, Tong AHY, Pons C, Ward HN, Ross C, van Leeuwen J, Aregger M, Lawson KA, Mair B, Roth AF, Sen NE, Forster D, Tan G, Mero P, Masud SN, Lee Y, Aguilera-Uribe M, Usaj M, Almeida SMT, Aulakh K, Bhojoo U, Birkadze S, Budijono N, Cai X, Caumanns JJ, Chandrashekhar M, Chang D, Climie R, Dasgupta K, Drazic A, Rojas Echenique JI, Gacesa R, Granda Farias A, Habsid A, Horecka I, Kantautas K, Ji F, Kim DK, Lee SY, Liang W, Lim J, Lin K, Lu X, Nami B, Nixon A, Mikolajewicz N, Nedyalkova L, Rohde T, Sartori Rodrigues M, Soste M, Schultz E, Wang W, Seetharaman A, Shuteriqi E, Sizova O, Thomson Taylor D, Tereshchenko M, Tieu D, Turowec J, Ubhi T, Varland S, Wang KE, Wang ZY, Wei J, Xiao YX, Brown GW, Cravatt BF, Dixon SJ, Wyatt HDM, Röst HL, Roth FP, Xia T, Bader GD, Loewith R, Davis NG, Andrews B, Myers CL, Moffat J, Boone C. Billmann M, et al. Among authors: aregger m. bioRxiv [Preprint]. 2025 Jul 2:2025.06.30.662193. doi: 10.1101/2025.06.30.662193. bioRxiv. 2025. PMID: 40631273 Free PMC article. Preprint.
Genome-scale exon perturbation screens uncover exons critical for cell fitness.
Xiao MS, Damodaran AP, Kumari B, Dickson E, Xing K, On TA, Parab N, King HE, Perez AR, Guiblet WM, Duncan G, Che A, Chari R, Andresson T, Vidigal JA, Weatheritt RJ, Aregger M, Gonatopoulos-Pournatzis T. Xiao MS, et al. Among authors: aregger m. Mol Cell. 2024 Jul 11;84(13):2553-2572.e19. doi: 10.1016/j.molcel.2024.05.024. Epub 2024 Jun 24. Mol Cell. 2024. PMID: 38917794 Free PMC article.
Reproducibility metrics for context-specific CRISPR screens.
Billmann M, Ward HN, Aregger M, Costanzo M, Andrews BJ, Boone C, Moffat J, Myers CL. Billmann M, et al. Among authors: aregger m. Cell Syst. 2023 May 17;14(5):418-422.e2. doi: 10.1016/j.cels.2023.04.003. Cell Syst. 2023. PMID: 37201508 Free PMC article.
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux.
Masud SN, Chandrashekhar M, Aregger M, Tan G, Zhang X, Mero P, Pirman DA, Zaslaver O, Smolen GA, Lin ZY, Wong CJ, Boone C, Gingras AC, Montenegro-Burke JR, Moffat J. Masud SN, et al. Among authors: aregger m. Nat Chem Biol. 2022 Dec;18(12):1370-1379. doi: 10.1038/s41589-022-01109-0. Epub 2022 Aug 15. Nat Chem Biol. 2022. PMID: 35970996
30 results