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A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability.
Temps C, Lietha D, Webb ER, Li XF, Dawson JC, Muir M, Macleod KG, Valero T, Munro AF, Contreras-Montoya R, Luque-Ortega JR, Fraser C, Beetham H, Schoenherr C, Lopalco M, Arends MJ, Frame MC, Qian BZ, Brunton VG, Carragher NO, Unciti-Broceta A. Temps C, et al. Among authors: arends mj. Cancer Res. 2021 Nov 1;81(21):5438-5450. doi: 10.1158/0008-5472.CAN-21-0613. Epub 2021 Aug 20. Cancer Res. 2021. PMID: 34417202 Free PMC article.
Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells.
Crittenden S, Goepp M, Pollock J, Robb CT, Smyth DJ, Zhou Y, Andrews R, Tyrrell V, Gkikas K, Adima A, O'Connor RA, Davies L, Li XF, Yao HX, Ho GT, Zheng X, Mair A, Vermeren S, Qian BZ, Mole DJ, Gerasimidis K, Schwarze JKJ, Breyer RM, Arends MJ, O'Donnell VB, Iredale JP, Anderton SM, Narumiya S, Maizels RM, Rossi AG, Howie SE, Yao C. Crittenden S, et al. Among authors: arends mj. Sci Adv. 2021 Feb 12;7(7):eabd7954. doi: 10.1126/sciadv.abd7954. Print 2021 Feb. Sci Adv. 2021. PMID: 33579710 Free PMC article.
MYC sensitises cells to apoptosis by driving energetic demand.
Edwards-Hicks J, Su H, Mangolini M, Yoneten KK, Wills J, Rodriguez-Blanco G, Young C, Cho K, Barker H, Muir M, Guerrieri AN, Li XF, White R, Manasterski P, Mandrou E, Wills K, Chen J, Abraham E, Sateri K, Qian BZ, Bankhead P, Arends M, Gammoh N, von Kriegsheim A, Patti GJ, Sims AH, Acosta JC, Brunton V, Kranc KR, Christophorou M, Pearce EL, Ringshausen I, Finch AJ. Edwards-Hicks J, et al. Nat Commun. 2022 Aug 9;13(1):4674. doi: 10.1038/s41467-022-32368-z. Nat Commun. 2022. PMID: 35945217 Free PMC article.
Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis.
van der Weyden L, Papaspyropoulos A, Poulogiannis G, Rust AG, Rashid M, Adams DJ, Arends MJ, O'Neill E. van der Weyden L, et al. Among authors: arends mj. Cancer Res. 2012 Aug 1;72(15):3817-3827. doi: 10.1158/0008-5472.CAN-11-3343. Epub 2012 Jun 18. Cancer Res. 2012. PMID: 22710434 Free PMC article.
MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype.
Sodir NM, Kortlever RM, Barthet VJA, Campos T, Pellegrinet L, Kupczak S, Anastasiou P, Swigart LB, Soucek L, Arends MJ, Littlewood TD, Evan GI. Sodir NM, et al. Among authors: arends mj. Cancer Discov. 2020 Apr;10(4):588-607. doi: 10.1158/2159-8290.CD-19-0435. Epub 2020 Jan 15. Cancer Discov. 2020. PMID: 31941709
199 results