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A tale of two Paks.
Arias-Romero LE, Chernoff J. Arias-Romero LE, et al. Biol Cell. 2008 Feb;100(2):97-108. doi: 10.1042/BC20070109. Biol Cell. 2008. PMID: 18199048 Review.
Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition.
Villamar Cruz O, Prudnikova TY, Araiza-Olivera D, Perez-Plasencia C, Johnson N, Bernhardy AJ, Slifker M, Renner C, Chernoff J, Arias-Romero LE. Villamar Cruz O, et al. Among authors: arias romero le. Oncotarget. 2016 Nov 22;7(47):76590-76603. doi: 10.18632/oncotarget.12576. Oncotarget. 2016. PMID: 27740936 Free PMC article.
H-ras Inhibits the Hippo Pathway by Promoting Mst1/Mst2 Heterodimerization.
Rawat SJ, Araiza-Olivera D, Arias-Romero LE, Villamar-Cruz O, Prudnikova TY, Roder H, Chernoff J. Rawat SJ, et al. Among authors: arias romero le. Curr Biol. 2016 Jun 20;26(12):1556-1563. doi: 10.1016/j.cub.2016.04.027. Epub 2016 May 26. Curr Biol. 2016. PMID: 27238285 Free PMC article.
Targeting Cdc42 in cancer.
Arias-Romero LE, Chernoff J. Arias-Romero LE, et al. Expert Opin Ther Targets. 2013 Nov;17(11):1263-73. doi: 10.1517/14728222.2013.828037. Epub 2013 Aug 19. Expert Opin Ther Targets. 2013. PMID: 23957315 Free PMC article. Review.
Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells.
Arias-Romero LE, Villamar-Cruz O, Huang M, Hoeflich KP, Chernoff J. Arias-Romero LE, et al. Cancer Res. 2013 Jun 15;73(12):3671-82. doi: 10.1158/0008-5472.CAN-12-4453. Epub 2013 Apr 10. Cancer Res. 2013. PMID: 23576562 Free PMC article.
p21-activated kinases in Erbb2-positive breast cancer: A new therapeutic target?
Arias-Romero LE, Chernoff J. Arias-Romero LE, et al. Small GTPases. 2010 Sep;1(2):124-128. doi: 10.4161/sgtp.1.2.14109. Small GTPases. 2010. PMID: 21686266 Free PMC article.
Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development.
Lightcap CM, Kari G, Arias-Romero LE, Chernoff J, Rodeck U, Williams JC. Lightcap CM, et al. PLoS One. 2009 Jun 26;4(6):e6025. doi: 10.1371/journal.pone.0006025. PLoS One. 2009. PMID: 19557173 Free PMC article.
A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells.
Arias-Romero LE, Villamar-Cruz O, Pacheco A, Kosoff R, Huang M, Muthuswamy SK, Chernoff J. Arias-Romero LE, et al. Oncogene. 2010 Oct 28;29(43):5839-49. doi: 10.1038/onc.2010.318. Epub 2010 Aug 16. Oncogene. 2010. PMID: 20711231 Free PMC article.
Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells.
Arias-Romero LE, Saha S, Villamar-Cruz O, Yip SC, Ethier SP, Zhang ZY, Chernoff J. Arias-Romero LE, et al. Cancer Res. 2009 Jun 1;69(11):4582-8. doi: 10.1158/0008-5472.CAN-08-4001. Epub 2009 May 12. Cancer Res. 2009. PMID: 19435911 Free PMC article.
p21 Activated kinase 1: Nuclear activity and its role during DNA damage repair.
Pérez-Yépez EA, Saldívar-Cerón HI, Villamar-Cruz O, Pérez-Plasencia C, Arias-Romero LE. Pérez-Yépez EA, et al. Among authors: arias romero le. DNA Repair (Amst). 2018 May;65:42-46. doi: 10.1016/j.dnarep.2018.03.004. Epub 2018 Mar 21. DNA Repair (Amst). 2018. PMID: 29597073 Review.
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