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CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.
Skowera A, Ellis RJ, Varela-Calviño R, Arif S, Huang GC, Van-Krinks C, Zaremba A, Rackham C, Allen JS, Tree TI, Zhao M, Dayan CM, Sewell AK, Unger WW, Drijfhout JW, Ossendorp F, Roep BO, Peakman M. Skowera A, et al. Among authors: arif s. J Clin Invest. 2008 Oct;118(10):3390-402. doi: 10.1172/JCI35449. J Clin Invest. 2008. PMID: 18802479 Free PMC article.
Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes.
Arif S, Leete P, Nguyen V, Marks K, Nor NM, Estorninho M, Kronenberg-Versteeg D, Bingley PJ, Todd JA, Guy C, Dunger DB, Powrie J, Willcox A, Foulis AK, Richardson SJ, de Rinaldis E, Morgan NG, Lorenc A, Peakman M. Arif S, et al. Diabetes. 2014 Nov;63(11):3835-45. doi: 10.2337/db14-0365. Epub 2014 Jun 17. Diabetes. 2014. PMID: 24939426 Free PMC article.
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