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Pituitary adenylate cyclase activating polypeptide (PACAP): discovery and current status of research.
Arimura A. Arimura A. Regul Pept. 1992 Feb 18;37(3):287-303. Regul Pept. 1992. PMID: 1313597 Review.
PACAP was found in a high concentration in the central nervous system, adrenal medulla and testis. Immunohistochemical study indicated that PACAP containing neural fibers are present throughout the brain, including both internal and external zones of the median eminence. . …
PACAP was found in a high concentration in the central nervous system, adrenal medulla and testis. Immunohistochemical study indicate …
Receptors for pituitary adenylate cyclase-activating polypeptide: comparison with vasoactive intestinal peptide receptors.
Arimura A. Arimura A. Trends Endocrinol Metab. 1992 Oct;3(8):288-94. doi: 10.1016/1043-2760(92)90139-r. Trends Endocrinol Metab. 1992. PMID: 18407113
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a new member of the secretin glucagon-vasoactive intestinal peptide (VIP) family of peptides, being most homologous to VIP. ...
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a new member of the secretin glucagon-vasoactive intestinal peptide (VI …
Tissue distribution of PACAP27 and -38 in oligochaeta: PACAP27 is the predominant form in the nervous system of Lumbricus polyphemus.
Somogyvári-Vigh A, Reglödi D, Li M, Lengvári I, Vigh S, Arimura A. Somogyvári-Vigh A, et al. Peptides. 2000 Aug;21(8):1185-91. doi: 10.1016/s0196-9781(00)00258-8. Peptides. 2000. PMID: 11035204
Moreover, the reproductive system also contained a substantial amount of PACAP. The dominant form of the peptide discovered in the majority of tissues was PACAP27. Interestingly, about 10 times more PACAP27 than PACAP38 was found, with the latter representing only a
Moreover, the reproductive system also contained a substantial amount of PACAP. The dominant form of the peptide discovered in the ma …
Hindbrain effects of PACAP on gastric motor function in the rat.
Krowicki ZK, Arimura A, Nathan NA, Hornby PJ. Krowicki ZK, et al. Am J Physiol. 1997 May;272(5 Pt 1):G1221-9. doi: 10.1152/ajpgi.1997.272.5.G1221. Am J Physiol. 1997. PMID: 9176233
Effect of PACAP on LH release studied by cell immunoblot assay depends on the gender, on the time of day and in female rats on the day of the estrous cycle.
Szabó E, Nemeskéri A, Arimura A, Köves K. Szabó E, et al. Regul Pept. 2004 Dec 15;123(1-3):139-45. doi: 10.1016/j.regpep.2004.04.021. Regul Pept. 2004. PMID: 15518904
In males, there was a decrease of LH due to PACAP treatment at 10 and 20 h; however, PACAP did not influence LH at 16 h. It was concluded that in vivo PACAP might be involved in the circadian and episodic release of LH at pituitary level....
In males, there was a decrease of LH due to PACAP treatment at 10 and 20 h; however, PACAP did not influence LH at 16 h. It was concl …
Cell immunoblot assay study demonstrating the release of PACAP from individual anterior pituitary cells of rats and the effect of PACAP on LH release.
Szabó E, Nemeskéri A, Heinzlmann A, Suzuki N, Arimura A, Köves K. Szabó E, et al. Regul Pept. 2002 Nov 15;109(1-3):75-81. doi: 10.1016/s0167-0115(02)00186-6. Regul Pept. 2002. PMID: 12409218
The released peptide, trapped by the nitrocellulose membrane forming a blot around the cells, was demonstrated by immunocytochemistry. ...In cell culture in a similar concentration, PACAP stimulated the LH release from female gonadotropes, but did not influence it f …
The released peptide, trapped by the nitrocellulose membrane forming a blot around the cells, was demonstrated by immunocytochemistry …
Neonatal PACAP administration in rats delays puberty through the influence of the LHRH neuronal system.
Szabó F, Horváth J, Heinzlmann A, Arimura A, Köves K. Szabó F, et al. Regul Pept. 2002 Nov 15;109(1-3):49-55. doi: 10.1016/s0167-0115(02)00185-4. Regul Pept. 2002. PMID: 12409214
The onset of puberty is a concerted action of many factors which leads to cyclic LHRH release in rats. It has been demonstrated that; in common with vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase activating polypeptide (PACAP) is also involved in the …
The onset of puberty is a concerted action of many factors which leads to cyclic LHRH release in rats. It has been demonstrated that; …
Distribution of PACAP-like immunoreactivity in the nervous system of oligochaeta.
Reglödi D, Lengvari I, Szelier M, Vigh S, Arimura A. Reglödi D, et al. Peptides. 2000 Feb;21(2):183-8. doi: 10.1016/s0196-9781(99)00201-6. Peptides. 2000. PMID: 10764943
A few cells and fibers were found in the medial and lateral parts of the subesophageal and ventral cord ganglia. In the peripheral nervous system, immunoreactivity was found in the enteric nervous system, in epidermal sensory cells, and in the clitellum....
A few cells and fibers were found in the medial and lateral parts of the subesophageal and ventral cord ganglia. In the peripheral ne
PACAP protects hippocampal neurons against apoptosis: involvement of JNK/SAPK signaling pathway.
Shioda S, Ozawa H, Dohi K, Mizushima H, Matsumoto K, Nakajo S, Takaki A, Zhou CJ, Nakai Y, Arimura A. Shioda S, et al. Ann N Y Acad Sci. 1998 Dec 11;865:111-7. doi: 10.1111/j.1749-6632.1998.tb11169.x. Ann N Y Acad Sci. 1998. PMID: 9928003
The ischemic stress had a potent influence on the MAP kinase family, especially on JNK/SAPK. PACAP inhibited the activation of JNK/SAPK after ischemic stress. ...
The ischemic stress had a potent influence on the MAP kinase family, especially on JNK/SAPK. PACAP inhibited the activation of JNK/SA …
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