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Mechanism by which phosphonoformic acid resistance mutations restore 3'-azido-3'-deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase.
Arion D, Sluis-Cremer N, Parniak MA. Arion D, et al. J Biol Chem. 2000 Mar 31;275(13):9251-5. doi: 10.1074/jbc.275.13.9251. J Biol Chem. 2000. PMID: 10734063 Free article.
We previously showed that pyrophosphorolytic removal of chain-terminating AZT is the primary mechanism of the AZT resistance phenotype (Arion, D., Kaushik, N., McCormick, S., Borkow, G., and Parniak, M. ...
We previously showed that pyrophosphorolytic removal of chain-terminating AZT is the primary mechanism of the AZT resistance phenotype (A
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