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Cell death by necrosis, a regulated way to go.
Henriquez M, Armisén R, Stutzin A, Quest AF. Henriquez M, et al. Curr Mol Med. 2008 May;8(3):187-206. doi: 10.2174/156652408784221289. Curr Mol Med. 2008. PMID: 18473819 Review.
Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity.
Echeverría C, Montorfano I, Hermosilla T, Armisén R, Velásquez LA, Cabello-Verrugio C, Varela D, Simon F. Echeverría C, et al. PLoS One. 2014 Apr 7;9(4):e94146. doi: 10.1371/journal.pone.0094146. eCollection 2014. PLoS One. 2014. PMID: 24710004 Free PMC article.
Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death.
Becerra A, Echeverría C, Varela D, Sarmiento D, Armisén R, Nuñez-Villena F, Montecinos M, Simon F. Becerra A, et al. Cardiovasc Res. 2011 Sep 1;91(4):677-84. doi: 10.1093/cvr/cvr135. Epub 2011 May 11. Cardiovasc Res. 2011. PMID: 21565835
Increased expression of the transient receptor potential melastatin 7 channel is critically involved in lipopolysaccharide-induced reactive oxygen species-mediated neuronal death.
Nuñez-Villena F, Becerra A, Echeverría C, Briceño N, Porras O, Armisén R, Varela D, Montorfano I, Sarmiento D, Simon F. Nuñez-Villena F, et al. Antioxid Redox Signal. 2011 Nov 1;15(9):2425-38. doi: 10.1089/ars.2010.3825. Epub 2011 Jun 24. Antioxid Redox Signal. 2011. PMID: 21539414
Hydrogen peroxide removes TRPM4 current desensitization conferring increased vulnerability to necrotic cell death.
Simon F, Leiva-Salcedo E, Armisén R, Riveros A, Cerda O, Varela D, Eguiguren AL, Olivero P, Stutzin A. Simon F, et al. J Biol Chem. 2010 Nov 26;285(48):37150-8. doi: 10.1074/jbc.M110.155390. Epub 2010 Sep 30. J Biol Chem. 2010. PMID: 20884614 Free PMC article.
Activation of H2O2-induced VSOR Cl- currents in HTC cells require phospholipase Cgamma1 phosphorylation and Ca2+ mobilisation.
Varela D, Simon F, Olivero P, Armisén R, Leiva-Salcedo E, Jørgensen F, Sala F, Stutzin A. Varela D, et al. Cell Physiol Biochem. 2007;20(6):773-80. doi: 10.1159/000110437. Cell Physiol Biochem. 2007. PMID: 17982259
The H(2)O(2)-induced [Ca(2+)](i) rise was prevented by the generic phospholipase C (PLC) inhibitor U73122 and the inositol 1,4,5-trisphosphate-receptor (IP(3)R) blocker 2-APB. ...
The H(2)O(2)-induced [Ca(2+)](i) rise was prevented by the generic phospholipase C (PLC) inhibitor U73122 and the inositol 1,4,5-trisphospha …
Chalcone-Induced Apoptosis through Caspase-Dependent Intrinsic Pathways in Human Hepatocellular Carcinoma Cells.
Ramirez-Tagle R, Escobar CA, Romero V, Montorfano I, Armisén R, Borgna V, Jeldes E, Pizarro L, Simon F, Echeverria C. Ramirez-Tagle R, et al. Int J Mol Sci. 2016 Feb 22;17(2):260. doi: 10.3390/ijms17020260. Int J Mol Sci. 2016. PMID: 26907262 Free PMC article.
TRPM4 regulates Akt/GSK3-β activity and enhances β-catenin signaling and cell proliferation in prostate cancer cells.
Sagredo AI, Sagredo EA, Cappelli C, Báez P, Andaur RE, Blanco C, Tapia JC, Echeverría C, Cerda O, Stutzin A, Simon F, Marcelain K, Armisén R. Sagredo AI, et al. Among authors: armisen r. Mol Oncol. 2018 Feb;12(2):151-165. doi: 10.1002/1878-0261.12100. Epub 2017 Dec 30. Mol Oncol. 2018. PMID: 28614631 Free PMC article.
TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines.
Sagredo AI, Sagredo EA, Pola V, Echeverría C, Andaur R, Michea L, Stutzin A, Simon F, Marcelain K, Armisén R. Sagredo AI, et al. Among authors: armisen r. J Cell Physiol. 2019 Mar;234(3):2037-2050. doi: 10.1002/jcp.27371. Epub 2018 Oct 21. J Cell Physiol. 2019. PMID: 30343491
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