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Polycystin-1 activates and stabilizes the polycystin-2 channel.
Xu GM, González-Perrett S, Essafi M, Timpanaro GA, Montalbetti N, Arnaout MA, Cantiello HF. Xu GM, et al. Among authors: arnaout ma. J Biol Chem. 2003 Jan 17;278(3):1457-62. doi: 10.1074/jbc.M209996200. Epub 2002 Oct 28. J Biol Chem. 2003. PMID: 12407099
Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel.
González-Perrett S, Kim K, Ibarra C, Damiano AE, Zotta E, Batelli M, Harris PC, Reisin IL, Arnaout MA, Cantiello HF. González-Perrett S, et al. Among authors: arnaout ma. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1182-7. doi: 10.1073/pnas.98.3.1182. Proc Natl Acad Sci U S A. 2001. PMID: 11252306 Free PMC article.
Polycystin-1 interacts with intermediate filaments.
Xu GM, Sikaneta T, Sullivan BM, Zhang Q, Andreucci M, Stehle T, Drummond I, Arnaout MA. Xu GM, et al. Among authors: arnaout ma. J Biol Chem. 2001 Dec 7;276(49):46544-52. doi: 10.1074/jbc.M107828200. Epub 2001 Oct 1. J Biol Chem. 2001. PMID: 11581269
Polycystin 1 is required for the structural integrity of blood vessels.
Kim K, Drummond I, Ibraghimov-Beskrovnaya O, Klinger K, Arnaout MA. Kim K, et al. Among authors: arnaout ma. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1731-6. doi: 10.1073/pnas.040550097. Proc Natl Acad Sci U S A. 2000. PMID: 10677526 Free PMC article.
166 results