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Aggrecan protects cartilage collagen from proteolytic cleavage.
Pratta MA, Yao W, Decicco C, Tortorella MD, Liu RQ, Copeland RA, Magolda R, Newton RC, Trzaskos JM, Arner EC. Pratta MA, et al. J Biol Chem. 2003 Nov 14;278(46):45539-45. doi: 10.1074/jbc.M303737200. Epub 2003 Jul 30. J Biol Chem. 2003. PMID: 12890681
Aggrecanase-mediated cartilage degradation.
Arner EC. Arner EC. Curr Opin Pharmacol. 2002 Jun;2(3):322-9. doi: 10.1016/s1471-4892(02)00148-0. Curr Opin Pharmacol. 2002. PMID: 12020478 Review.
ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms.
Tortorella MD, Arner EC, Hills R, Gormley J, Fok K, Pegg L, Munie G, Malfait AM. Tortorella MD, et al. Arch Biochem Biophys. 2005 Dec 1;444(1):34-44. doi: 10.1016/j.abb.2005.09.018. Epub 2005 Oct 26. Arch Biochem Biophys. 2005. PMID: 16289022
Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4).
Tortorella MD, Pratta M, Liu RQ, Austin J, Ross OH, Abbaszade I, Burn T, Arner E. Tortorella MD, et al. Among authors: arner e. J Biol Chem. 2000 Jun 16;275(24):18566-73. doi: 10.1074/jbc.M909383199. J Biol Chem. 2000. PMID: 10751421
., Hollis, G. F., Newton, R. C., Magolda, R. L., Trzaskos, J. M., and Arner, E. C. (1999) Science 284, 1664-1666) and herein demonstrate that in addition to cleavage at the Glu(373)-Ala(374) bond, this protease cleaves at four sites within the chondroitin-sulfate ri …
., Hollis, G. F., Newton, R. C., Magolda, R. L., Trzaskos, J. M., and Arner, E. C. (1999) Science 284, 1664-1666) and herein d …
The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage.
Tortorella M, Pratta M, Liu RQ, Abbaszade I, Ross H, Burn T, Arner E. Tortorella M, et al. Among authors: arner e. J Biol Chem. 2000 Aug 18;275(33):25791-7. doi: 10.1074/jbc.M001065200. J Biol Chem. 2000. PMID: 10827174
., Wiswall, B. H., Murphy, K., Hillman, M. C., Jr., Hollis, G. F., and Arner, E.C. (1999) Science 284, 1664-1666; 2 Abbaszade, I., Liu, R. ...
., Wiswall, B. H., Murphy, K., Hillman, M. C., Jr., Hollis, G. F., and Arner, E.C. (1999) Science 284, 1664-1666; 2 Abbaszade, …
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