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A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha.
Siggs OM, Berger M, Krebs P, Arnold CN, Eidenschenk C, Huber C, Pirie E, Smart NG, Khovananth K, Xia Y, McInerney G, Karlsson Hedestam GB, Nemazee D, Beutler B. Siggs OM, et al. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3046-51. doi: 10.1073/pnas.0915098107. Epub 2010 Jan 28. Proc Natl Acad Sci U S A. 2010. PMID: 20133626 Free PMC article.
Increased susceptibility to DNA virus infection in mice with a GCN2 mutation.
Won S, Eidenschenk C, Arnold CN, Siggs OM, Sun L, Brandl K, Mullen TM, Nemerow GR, Moresco EM, Beutler B. Won S, et al. Among authors: Arnold CN. J Virol. 2012 Feb;86(3):1802-8. doi: 10.1128/JVI.05660-11. Epub 2011 Nov 23. J Virol. 2012. PMID: 22114338 Free PMC article.
ENU-induced phenovariance in mice: inferences from 587 mutations.
Arnold CN, Barnes MJ, Berger M, Blasius AL, Brandl K, Croker B, Crozat K, Du X, Eidenschenk C, Georgel P, Hoebe K, Huang H, Jiang Z, Krebs P, La Vine D, Li X, Lyon S, Moresco EM, Murray AR, Popkin DL, Rutschmann S, Siggs OM, Smart NG, Sun L, Tabeta K, Webster V, Tomisato W, Won S, Xia Y, Xiao N, Beutler B. Arnold CN, et al. BMC Res Notes. 2012 Oct 24;5:577. doi: 10.1186/1756-0500-5-577. BMC Res Notes. 2012. PMID: 23095377 Free PMC article.
A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.
Arnold CN, Pirie E, Dosenovic P, McInerney GM, Xia Y, Wang N, Li X, Siggs OM, Karlsson Hedestam GB, Beutler B. Arnold CN, et al. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12286-93. doi: 10.1073/pnas.1209134109. Epub 2012 Jul 3. Proc Natl Acad Sci U S A. 2012. PMID: 22761313 Free PMC article.
The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow.
Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, Nemazee D, Beutler B. Siggs OM, et al. Among authors: Arnold CN. Nat Immunol. 2011 May;12(5):434-40. doi: 10.1038/ni.2012. Epub 2011 Mar 20. Nat Immunol. 2011. PMID: 21423172 Free PMC article.
Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells.
Blasius AL, Arnold CN, Georgel P, Rutschmann S, Xia Y, Lin P, Ross C, Li X, Smart NG, Beutler B. Blasius AL, et al. Among authors: Arnold CN. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19973-8. doi: 10.1073/pnas.1014051107. Epub 2010 Nov 2. Proc Natl Acad Sci U S A. 2010. PMID: 21045126 Free PMC article.
Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells.
Eidenschenk C, Crozat K, Krebs P, Arens R, Popkin D, Arnold CN, Blasius AL, Benedict CA, Moresco EM, Xia Y, Beutler B. Eidenschenk C, et al. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9759-64. doi: 10.1073/pnas.1005186107. Epub 2010 May 10. Proc Natl Acad Sci U S A. 2010. PMID: 20457904 Free PMC article.
Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice.
Barnes MJ, Aksoylar H, Krebs P, Bourdeau T, Arnold CN, Xia Y, Khovananth K, Engel I, Sovath S, Lampe K, Laws E, Saunders A, Butcher GW, Kronenberg M, Steinbrecher K, Hildeman D, Grimes HL, Beutler B, Hoebe K. Barnes MJ, et al. J Immunol. 2010 Apr 1;184(7):3743-54. doi: 10.4049/jimmunol.0903164. Epub 2010 Feb 26. J Immunol. 2010. PMID: 20190135 Free PMC article.
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